Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 854 for “"IL-6"”.
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Bedeutung der IL-6-Signaltransduktionsinhibitoren SHP2 und SOCS3 für die Desensitisierung des IL-6-Signalweges
… immediate early response of cells treated with IL-6 (interleukin-6) is the activation of the signal transducer and activator of transcription (STAT) 3. The Src homology domain 2 (SH2)-containing protein tyrosine phosphatase SHP2 and the feedback inhibitor SOCS3 (suppressor of cytokine …
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STAT3-protein interactions in IL-6/gp130 signaling
… is a central transcription factor downstream of IL-6/gp130 signaling. This thesis investigates how STAT3 regulates IL-6 signal transduction by interacting with its coactivators. First, the function of an IL-6 inducible complex of STAT3 with cyclin-dependent kinase 9 (CDK9) was examined by using …
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The Role of IL-6 in Inflammatory Aortic Aneurysmal Diseases
Interleukin-6 (IL-6), a member of a superfamily of cardioactive cytokines, has been identified as an independent biomarker of vascular diseases including atherosclerosis and aortic aneurysms. Local vascular IL-6 secretion can be induced by dysregulated angiotensin II (Ang II) signaling, producing …
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Das Adapterprotein Gab1 in der Regulation der IL-6 Signaltransduktion
… It was described that Gab1 is involved in the IL-6 mediated ERK-activation. However, the mechanisms of the activation of the MAPK-cascade after activation of the IL-6 receptor gp130 are still unclear. Therefore, in the study presented here, these mechanisms were investigated in molecular …
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The Role of Il-6 In Adenosine-Mediated Pulmonary Fibrosis
… have demonstrated that adenosine up-regulates IL-6 production through the engagement of the A<sub>2B</sub> adenosine receptor in various cell types, including alveolar macrophages. IL-6 is elevated in mouse models and humans with chronic lung disease, suggesting a potential role in disease …
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Ortsgerichtete Immobilisierung fluoreszenzmarkierter IL-6-Typ-Zytokine und Analyse ihrer Signaltransduktion
IL-6-type cytokines have a significant function in modulating the inflammatory response and wound healing process. They influence growth, proliferation and differentiation of various cell types. Therefore, the functionalization of biomaterial surfaces with IL-6-type cytokines permits the control of …
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Einfluss von metabolisch wirksamen Hormonen auf die IL-6-induzierte Signaltransduktion
The cytokine interleukin (IL)-6 exerts pro- and anti-inflammatory properties and is a main inducer of the acute-phase response. It is involved in the pathogenesis of inflammatory diseases like for example rheumatoid arthritis or multiple sclerosis. Glucocorticoids are steroid hormones that are …
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Modulation der IL-6-abhängigen Signaltransduktion durch die Protein-Tyrosinphosphatase SHP2
… of the tyrosine phosporylation of SHP2 in the IL-6 dependent signaltransduction via the Jak/STAT pathway. Therefore, first the dose-dependence, kinetic and kinase requirements for SHP2 phosphorylation after the activation of the signal transducer, gp130, was examined. When human fibrosarcoma …
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Autocrine Effects of Catecholamines on Macrophage Release of Interleukin-6 (IL-6)
… and inhibitory effects on interleukin-6 (IL-6). This study was designed to clarify the autocrine role of macrophage-derived NE on IL-6 production in activated peritoneal macrophages. Effects of NE on IL-6 production in the RAW264.7 macrophage cell-line also were investigated. Treatment of …
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Der Transkriptionsfaktor FKHR interagiert mit STAT-Faktoren und verstärkt die IL-6-Signaltransduktion
… phase proteins in hepatocytes. This thesis will give a possible reason for this observation. An important pathway of signal transduction of growth factors depends on the activation of PI3 kinase and the ProteinkinaseB (PkB). Within the cell the IL6 signal is mediated via Janus kinases and …
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Repression der IL-6-Signaltransduktion über das zytoplasmatische Tyrosin 759 des Signaltransduktors gp130
… in interleukin-6 signal transduction Three families of proteins involved in the down-regulation of cytokine signaling have been described recently: (i) SH2 domain containing protein tyrosine phosphatases (SHP), (ii) suppressors of cytokine signaling (SOCS) and (iii) protein inhibitors of …
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Exogenous Mitochondrial Transfer and IL-6: Modulating Adipocyte Metabolism in Obesity-associated Dysregulation
… promoting a favorable shift in metabolic profiles within white adipocytes. Mitochondria therapy also appeared to stimulate mitochondrial biogenesis through an increase in Ppara and Ppargc1a expression. Mitochondrial therapy also led to reduced lipid content, indicating a potential means to …
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Stimulation of chemotherapy-induced immunity by targeting IL-6 in the tumor microenvironment
… from cancer recurrence is the stimulation and mobilization of the immune system against tumor cells. To this end, preclinical studies of a group of cytostatic and genotoxic agents has shown that these drugs exert their effects on cancer cells by, in part, boosting the functions of immune cells. …
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Ischemic Stroke Damage Is Reduced By Inhibition of Il-6 Signaling With to cilizumab
… is the leading cause of serious long-term disability and is the 5<sup>th</sup> leading cause of death causing approximately 130,000 deaths in the United States every year {1}. Stroke is also the 2<sup>nd</sup> leading cause of death in American women {2}. Women are 33% more likely to require …
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Il-6/Jak1 Drives Pd-L1 Phosphorylation and Glycosylation to Promote Cancer Immune Evasion
… as T-cell receptor (TCR), major histocompatibility complex (MHC), and co-inhibitory molecules, regulates immune signaling activation, antigen presentation, and immune surveillance. Recent studies revealed that the glycan structures of co-inhibitory molecules are required for receptor-ligand …
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Adenylyl Cyclase 2 Selectively Regulates IL-6 Expression in Human Bronchial Smooth Muscle Cells
… and activation of AC2 enhanced interleukin 6 (IL-6) expression, but overexpression of AC3 or AC6 had no effect. IL-6 production by BSMC was induced by Fsk and select G protein-coupled receptor (GPCR) agonists, though IL-6 levels did not directly correlate with intracellular cAMP levels. At low …
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