Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 778 for “"IL-6"”.
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STAT3-protein interactions in IL-6/gp130 signaling
… is a central transcription factor downstream of IL-6/gp130 signaling. This thesis investigates how STAT3 regulates IL-6 signal transduction by interacting with its coactivators. First, the function of an IL-6 inducible complex of STAT3 with cyclin-dependent kinase 9 (CDK9) was examined by using …
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The Role of IL-6 in Inflammatory Aortic Aneurysmal Diseases
Interleukin-6 (IL-6), a member of a superfamily of cardioactive cytokines, has been identified as an independent biomarker of vascular diseases including atherosclerosis and aortic aneurysms. Local vascular IL-6 secretion can be induced by dysregulated angiotensin II (Ang II) signaling, producing …
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The Role of Il-6 In Adenosine-Mediated Pulmonary Fibrosis
… have demonstrated that adenosine up-regulates IL-6 production through the engagement of the A<sub>2B</sub> adenosine receptor in various cell types, including alveolar macrophages. IL-6 is elevated in mouse models and humans with chronic lung disease, suggesting a potential role in disease …
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Autocrine Effects of Catecholamines on Macrophage Release of Interleukin-6 (IL-6)
… and inhibitory effects on interleukin-6 (IL-6). This study was designed to clarify the autocrine role of macrophage-derived NE on IL-6 production in activated peritoneal macrophages. Effects of NE on IL-6 production in the RAW264.7 macrophage cell-line also were investigated. Treatment of …
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Exogenous Mitochondrial Transfer and IL-6: Modulating Adipocyte Metabolism in Obesity-associated Dysregulation
… promoting a favorable shift in metabolic profiles within white adipocytes. Mitochondria therapy also appeared to stimulate mitochondrial biogenesis through an increase in Ppara and Ppargc1a expression. Mitochondrial therapy also led to reduced lipid content, indicating a potential means to …
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Stimulation of chemotherapy-induced immunity by targeting IL-6 in the tumor microenvironment
… from cancer recurrence is the stimulation and mobilization of the immune system against tumor cells. To this end, preclinical studies of a group of cytostatic and genotoxic agents has shown that these drugs exert their effects on cancer cells by, in part, boosting the functions of immune cells. …
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Ischemic Stroke Damage Is Reduced By Inhibition of Il-6 Signaling With to cilizumab
… is the leading cause of serious long-term disability and is the 5<sup>th</sup> leading cause of death causing approximately 130,000 deaths in the United States every year {1}. Stroke is also the 2<sup>nd</sup> leading cause of death in American women {2}. Women are 33% more likely to require …
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Il-6/Jak1 Drives Pd-L1 Phosphorylation and Glycosylation to Promote Cancer Immune Evasion
… as T-cell receptor (TCR), major histocompatibility complex (MHC), and co-inhibitory molecules, regulates immune signaling activation, antigen presentation, and immune surveillance. Recent studies revealed that the glycan structures of co-inhibitory molecules are required for receptor-ligand …
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Adenylyl Cyclase 2 Selectively Regulates IL-6 Expression in Human Bronchial Smooth Muscle Cells
… and activation of AC2 enhanced interleukin 6 (IL-6) expression, but overexpression of AC3 or AC6 had no effect. IL-6 production by BSMC was induced by Fsk and select G protein-coupled receptor (GPCR) agonists, though IL-6 levels did not directly correlate with intracellular cAMP levels. At low …
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Überlebenszeitabhängige Änderungen der zerebralen IL-6- und GFAP-Expression nach letalen Schädel-Hirn-Traumen
… zellulär sezernierten Zytokins Interleukin-6 (IL-6) und des zerebralen Intermediärfilamentes Saures Gliafaserprotein (GFAP) hinsichtlich ihrer Aussagekraft zur Detektion eines Schädel-Hirn-Traumas (SHT) und der Abschätzung des Überlebenszeitintervalls zwischen Erleiden der Gewalteinwirkung und …
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The role of central IL-6 signalling in the development of Type 2 Diabetes
… of these neuroendocrine networks. Interleukin 6 (IL-6) is a pleiotropic cytokine involved in the acute, as well as the resolving and adaptive phase of inflammatory responses. The IL-6 receptor has recently been shown to exhibit extensive localization in key regions of the human and rodent …
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Influence of Human and Viral IL-6 on KSHV Infection in Human Tonsil Lymphocytes
… events governing infection in B lymphocytes. IL-6 signaling plays a critical role in KSHV-mediated disease, where elevated hIL-6 levels are positively associated with KSHV viral load and disease progression. This dynamic is even more complex due to the co-existence of human IL-6 (hIL6) and …
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Spatially-defined quantitative interleukin 6 (IL-6) detection using polyethylene glycol microgel sensors (μGELISA)
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-11 without embargo terms
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Cytokine and neurotransmitter regulation of glial cell production of Il-6; indications for neurodegenerative disorders
The cytokines interleukin-1 (IL-1) and interleukin-6 (IL-6) are produced during an immune reaction and cause inflammation and swelling of the surrounding tissue. AD is a neurodegenerative disorder characterized by well-defined neuropathologic entities. Both IL-1 and IL-6 are present in senile …
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Mechanism of local IL-6 production and its role in accelerating vascular inflammation leading to aortic diseases
… are unclear. The cytokine interleukin-6 (IL-6) is highly induced in aortic aneurysm and dissection and significantly increases the risk of aneurysm rupture and mortality due to cardiovascular diseases; however, it remains unknown where and how IL-6 is produced in the vascular wall and how …
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Effects of N-3 polyunsaturated fatty acids on adipose stem cell production of interleukin-6 (IL-6)
Thesis (M.S.)--Michigan State University. Human Nutrition, 2010
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Einfluß des IL-6/sIL-6R Fusionsproteins Hyper Interleukin-6 auf die Leber nach hydrodynamischer Transfektion in vivo
… und Wachstumsfaktoren reguliert, wobei TNF-α, IL-6 und HGF eine Schlüsselrolle spielen. In früheren Studien konnte gezeigt werden, dass ein IL-6/sIL-6R Fusionsprotein, Hyper-IL-6, nach Leberschädigung stark regenerationsfördernd wirkt. In der vorliegenden Arbeit konnte Hyper-IL-6 Expression …
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Eine neue Domäne der IL-6 Rezeptor β -Kette, gp130, vermittelt Zellwachstum und die Aktivierung der Kinasen Hck und Erk
IL-6 spielt eine entscheidende Rolle für die Entstehung vieler Krankheiten, ins-besondere des Plasmozytoms. Über die molekularen Mechanismen die daran be-teiligt sind, lagen allerdings bisher wenig Daten vor. Aufgrund eigener Vorarbei-ten war bekannt, dass IL-6 die Src-Kinasen Hck, Fyn und Lyn …
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