Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 76 for “"IL-5"”.
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Protein Kinase A regulates GATA-3 dependent Activation of IL-5 Gene Expression in T Helper Lymphocytes
Die durch Agentien wie IL-1α, Prostaglandine oder Forskolin induzierte Erhöhung von intrazellulärem zyklischem Adenosin-Monophosphat (cAMP) in T-Lymphozyten inhibiert die Synthese Th1-typischer Zytokine und stimuliert die Synthese Th2-typischer Zytokine. Die für die cAMP-vermittelte Induktion von …
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The Role of GM-CSF/IL-3/IL-5 Receptor Common β Subunit (CBS) in Hematopoietic Stem and Progenitor Cell (HSPC) Expansion, Monocytosis and Atherosclerosis
… increased numbers of monocytes drive their infiltration into atherosclerotic plaques. Studies using animal models of atherosclerosis including Apolipo protein E knockout (Apoe-/-) mice and ATP binding cassette transporter A1(ABCA1) and ATP binding cassette transporter G1 (ABCG1) knockout …
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EOSINOPHILIC INFLAMMATION IN NASAL POLYPOSIS: REGULATION OF INTERLEUKIN 5 AND INTERLEUKIN 5 RECEPTOR α ISOFORMS
As the vast majority of bilateral nasal polyps (NP) are associated with a prominent eosinophilic inflammation and as eosinophils are well recognised in eliciting tissue damage and subsequent re-modelling, we aimed to investigate the role of eosinophils in the pathogenesis of NP. Especially the …
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Untersuchung der Interleukin-5-Rezeptor-Expression und der Aktivierung humaner eosinophiler Granulozyten
Der Eosinophile ist an der Ausprägung des klinischen Bildes allergischer Erkrankungen wesentlich beteiligt. In der BAL von Asthmatikern sind vermehrt die proinflammatorischen Zytokine IL-5 sowie IL-3 und GM-CSF nachzuweisen, im Sputum sind es erhöhte Konzentrationen des TH1-Zytokins IFN-g, sowie …
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Structural and functional studies of the Interleukin-5 receptor system
… long-term ongoing project on developing human IL-5 agonists/antagonists that intervene with or inhibit IL-5 numerous functions in cell culture and/or in animal disease models. To facilitate design of an IL-5 antagonist variant or low-molecular weight mimetics only capable of binding to the …
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Auswirkung der in-vitro Allergenstimulation auf die Zytokinexpression bei allergischen Erkrankungen : Untersuchung der Bildung von TH1- und TH2-Zytokinen und ihrer Beeinflussbarkeit durch den Histamin-Rezeptor-Antagonisten Desloratadin
… allergischen Erkrankungen <br>Untersuchung der Bildung von TH1- und TH2-Zytokinen und ihrer Beeinflussbarkeit durch den Histamin-Rezeptor-Antagonisten Desloratadin <br> <br>In der vorliegenden Arbeit wurde die allergische Entzündung am Modell der in-vitro Allergenstimulation untersucht. Periphere …
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CD30: A Novel Receptor to Induce Apoptosis in Human Blood Eosinophils
Eosinophils are one of the major effector cells in asthma, and controlling the number and survival of eosinophils might attenuate the severity of asthma. This could be achieved by inducing eosinophil apoptosis. Apoptosis allows the removal of cells without inducing an inflammatory response. Our …
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Maternal Immune Markers In Serum During Late Gestation and In Breast Milk and the Risk of Asthma-Like Symptoms At Ages 6 and 12 Months: A Longitudinal Study
<p>Background: The role of breast milk components on childhood asthma is controversial. The aims of this prospective study are to determine the relationship of immune markers in maternal serum during gestation and breast milk to asthma-like symptoms (AS) in infancy, and the association between …
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Autophagy mechanisms in sputum and peripheral blood cells of patients with severe asthma: a new therapeutic target
… blood cells (PBCs), and peripheral blood eosinophils (PBEs) between patients with severe asthma and those with non-severe asthma and investigated the functional effects of autophagy. Methods: We enrolled 36 patients with severe asthma, 14 with non-severe asthma, and 23 normal healthy controls in …
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Die Interaktion der Transkriptionsfaktoren NF-ATc und GATA-3 in T-Helfer-Zellen
Interleukin-5 ist ein Th2-Cytokin, das eosinophile Granulozyten aktiviert und B-Zellen zur Produktion von IgE stimuliert. Bei der Entstehung von allergischen (wie z.B. Asthma) und atopischen Reaktionen spielt die erhöhte Ausschüttung von IL-5 eine wichtige Rolle. Der Interleukin-5-Promoter weist …
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T-Regulatory Cells and FLT3-Ligand in the Therapy of Cockroach Antigen-induced Asthma
… cells, including mast cells, eosinophils, neutrophils, and lymphocytes, are critical in the initiation of the pathophysiological changes in asthma. The mobilization and recruitment of these inflammatory cells are primarily due to the release of proinflammatory cytokines (IL-4, IL-5, …
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Group 2 innate lymphoid cells and reproduction
… that tissue-resident innate lymphoid cells (ILCs) are crucial regulators of both physiology and pathology of the tissues they populate. Uterine natural killer (uNK) cells are a subtype of ILCs known to regulate trophoblast invasion, uterine vascular adaptation to pregnancy, and foetal growth. …
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MODELING, EXPERIMENTAL ANALYSIS AND OPTIMIZATION OF FLOATING PHOTOVOLTAIC POWER PLANTS
… dei sistemi FPV nei bacini idrici, sono stati sviluppati modelli numerici che consentono di stimare il tasso di evaporazione in relazione alle caratteristiche dei sistemi galleggianti e della superficie d'acqua occupata. Sono stati implementati modelli per valutare le prestazioni di diverse …
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Role of T cells and cytokines in the induction of tolerance to renal tubular antigen in active Heymann nephritis
… to end-stage kidney disease. The best available animal model of MN is active Heymann nephritis (HN) in which rats are immunized with renal tubular antigen (RTA) in complete Freund's adjuvant (CFA). Rats develop heavy proteinuria, a key measure of glomerular damage, and the disease is …
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Maternal Serum and Whey Immune Markers and Eczema Among Infants
<p>Eczema among children and its relation to maternal whey and serum immune markers are considered to either de- or increase risk of the skin disorder. We conducted a prospective study to contrast the role of different maternal immune markers (MIMs) in maternal serum and whey on the development of …
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Role of Notch Signaling in T Cell Polarization
… necessary for Th17 differentiation. Furthermore, IL-17 promoter assays and chromatin immuno-precipitation (ChIP) experiments revealed that IL-17 and ROR-γt are transcriptional targets of Notch1.</p><p>In this study I have also shown that Notch signaling also controls Th1 component of the Th17 …
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Bystander influence of nematode exposure on subsequent herpesvirus infections in vivo
Parasitic worms have the ability to modulate the hosts immune response to promote host control of the infection and also parasite survival in the host. Helminth infections classically induce a potent Th2-biased and regulatory immune imprint. This immune response also influences unrelated …
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Exacerbation and glucocorticoid toxicity profile in patients receiving mepolizumab for severe eosinophilic asthma
The treatment of patients with severe eosinophilic asthma has been transformed with the arrival of biological drugs targeting the type 2 cytokine pathway. One of these drugs is mepolizumab, a humanised monoclonal antibody against the eosinophil activating cytokine, interleukin (IL)-5, has …
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Molecular genetic mechanisms of eosinophil activation in aspirin-exacerbated respiratory disease : Genetic mechanisms of eosinophil activation
Background and Objective: Eosinophilic airway inflammation is a common pattern in various phenotypes of asthma. Persistent eosinophil activation finding in both upper and lower airway mucosa is a central feature of aspirin-exacerbated respiratory disease (AERD). As interleukin (IL)-5 mediated …
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Preparation, development and evaluation of novel drug delivery systems for colon targeting
Il direzionamento di farmaci al colon sta assumendo un ruolo sempre più importante non solo per il targeting di farmaci usati nel trattamento di patologie del colon ma anche come sito per l’assorbimento e raggiungimento sistemico di proteine. Lo scopo di questo lavoro è stato quello di preparare …
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