Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"IL-4 signaling"”.
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Generation of mice expressing a constitutively active stat6: a model for the analysis of IL-4 signaling and tumor progression
… scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Computational modeling of the IL-4 pathway to understand principles of systemic redox regulation in cell signaling
… and disease, years of clinical studies have failed to show clear benefits of antioxidant therapy. It is now recognized that ROS such as hydrogen peroxide can act as signaling molecules and are required for physiological functioning of a number of signaling pathways. Therefore, a mechanistic …
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Impaired Control of Chronic Herpesvirus Infection in Tissue Resident Macrophages During Coinfection with Intestinal Parasite and Other Cell-intrinsic Herpesvirus Interactions
… a variety of signals, such as HDAC inhibitors. While some of these signals are known, it is still unclear whether there are cell-specific reactivation mechanisms, and if so, which signals cause them. Further, human gammaherpesviruses are endemic in areas that also have a high prevalence of …
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Type I Interferon Mediates Th2 Reprogramming and Acute Suppression of Effector Functions
The type I interferon (IFN-α/β) family is a pleiotropic set of cytokines that play a role in regulating many biological functions, including suppressing viral replication and modulating adaptive immune functions. Although IFN-α/β has been extensively studied regarding the activation of interferon …
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Molecular mechanisms of neural stem cell plasticity and neuro-regeneration in an Alzheimer’s-like neurodegeneration model of adult zebrafish
… chronic inflammation that manifests through mild to late stages of the pathology cannot be resolved. The synaptic degeneration that underlies cognitive decline cannot be reversed. As a general outcome, neurons deteriorate and new neurons cannot replace the lost ones. This is in part due to …
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Effects of mannan oligosaccharide on immune function and disease resistance in pigs
… necrosis factor-α (TNF-α) (P < 0.01) and more IL-10 (P = 0.051) than AMφ from the control-fed pigs. Dietary MOS did not affect AMφ-produced cytokines induced by polyinosinic:polycytidylic acid (Poly I:C). When applied in vitro, MOS suppressed LPS-induced TNF-α (P < 0.001), but enhanced …