Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"IL-4 receptor"”.
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The role of IL-4 receptor alpha in chronic allergic airway disease (AAD)
Includes abstract.
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Investigating role of IL-4 receptor alpha (IL-4Ra) in murine models of atopic dermatitis
… show efficacy in AD patients. However, targeting IL-4/IL-13 signalling axis with dupilumab show efficacy in AD. We investigated the importance of interleukin 4 receptor alpha (IL- 4Rα) signalling specifically on B and T cells to understand the requirement of this signalling axis in epicutaneous …
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The Role of IL-4 Receptor Alpha signalling on Foxp3 T Regulatory cells in Listeriosis and Tuberculosis
… addressed the hypothesis that interleukin-4 receptor alpha (IL-4Rα) signalling on T regulatory cells (T reg) play a role in the stability of T reg cells. Loss of IL-4Rα signalling on T reg cells may shift the immune balance from a Foxp3+ T reg to a Th1 effector function essential for Th1 …
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Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection
In BALB/c mice, susceptibility to infection with the intracellular parasite Leishmania major is driven largely by the development of T helper 2 (Th2) responses and the production of interleukin (IL)-4 and IL-13, which share a common receptor subunit, the IL-4 receptor alpha chain (IL-4α ). While …
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Immune and allergic responses to Anisakis pegreffii, with focus on the roles of IL-4, IL-13 and the IL-4 receptor alpha
… and allergic responses to A. pegreffii in wildtype and gene deficient mice, with special focus on interleukin(IL)-4, IL-13, and the IL-4 receptor alpha (IL-4Rα). Experimental murine models of Anisakis infection, Anisakis-induced anaphylaxis and Anisakis-induced dermatitis were established in …
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Investigating the role of IL-4/IL-13 signalling through the IL-4 receptor alpha (IL-4Rα) on keratinocytes in murine models of Leishmania major and Schistosoma mansoni
… is important during the parasite life cycle. While Th1 immunity is required to control CL, protection during schistosomiasis requires Th2 immunity. Paradoxically, Th2 characteristic IL-4 secreted early during L. major infection in mice, can drive a Th1 response by instructing dendritic cells to …
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Characterisation of novel T cell specific IL-4 receptor-alpha knockout mice : investigating the role of T cell responses to IL-4 in Leishmania major and Nippostrongylus brasilliensis infections
Includes bibliographical references (leaves 76-86).
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The role of IL-4 and IL-13 responsiveness during Schistosoma mansoni induced inflammation
… the host’s survival. Where as T cell-specific IL-4Rα has been shown not to be essential for survival, macrophage/neutrophil-specific IL-4 receptor α-deficient mice (LysMIcre L-4Rα-/lox ), mice lacking alternative macrophages (AAMФ), had severe intestine pathology and high endotoxin levels due …
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Investigating the role of IL-4/IL-13 and their receptors in ulcerative colitis
… limited to the distal colon and mixed neutrophil/lymphocyte infiltration in the superficial layer of the mucosa. The Th2 cytokines interleukin (IL)-4 and IL-13 are associated with the onset of oxazolone colitis and both signal through a common IL-4 receptor-alpha chain (IL-4R +-). Neutralizing …
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Impaired Control of Chronic Herpesvirus Infection in Tissue Resident Macrophages During Coinfection with Intestinal Parasite and Other Cell-intrinsic Herpesvirus Interactions
… a variety of signals, such as HDAC inhibitors. While some of these signals are known, it is still unclear whether there are cell-specific reactivation mechanisms, and if so, which signals cause them. Further, human gammaherpesviruses are endemic in areas that also have a high prevalence of …
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Investigating the role of IL-4Rα mediated signalling on Foxp3⁺ T regulatory cells during cutaneous leishmaniasis
… characterized by the production of interleukin (IL)-4 and IL-13, which single through a common receptor, the IL-4 receptor alpha chain (IL-4Rα). Forkhead box P3 (Foxp3⁺) Regulatory T (Treg) cells are an unique subset of CD4⁺ T cells that play important immunomodulatory roles maintaining a balance …
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A mouse model of childhood asthma: mechanisms of development and progression following an early-life respiratory viral infection
… Lower respiratory tract infections in childhood, including viruses such as respiratory syncytial virus (RSV), are strongly linked to development of allergic asthma. The aim of this project was to develop a mouse model of the induction phase of childhood asthma, to facilitate investigation …
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Die Bedeutung der Expression des IL-4 Rezeptors für die Prognosestellung beim lokal begrenzten Nierenzellkarzinom
… zwischen dem Ausmaß der Expression von IL-4 Rezeptoren und der Prognose der Erkrankung gibt. 198 formalinfixierte und in Paraffin eingebettete Präparate von Nierenzellkarzinomen wurden immunhistochemisch aufgearbeitet und unter dem Lichtmikroskop ausgewertet. Mittels statistischer Tests …
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Role of Dendritic Cells in Pathology of Respiratory Syncytial Virus Infection in Neonates
… one of the leading causes of bronchiolitis in children. We have shown that neonatal mice respond to primary RSV infection with T helper type 2 (Th2) biased immune responses, which are enhanced following reinfection. Dendritic cells (DCs) including myeloid DCs (mDCs) and plasmacytoid DCs (pDCs) …
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Pflanzenzellen als Produktionssystem zur Gewinnung von Interleukin-4 Doppelmutein (IL-4 DM)
… from the Bayer-FhG joint project on "A feasibility study for recombinant protein production in plants". Its objective was to analyse and evaluate the extent to which plant expression systems would be able to produce pharmaceutical proteins; the test protein chosen for this feasibility study …