Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 33 for “"IL-33"”.
-
Investigating the roles of IL-25, IL-33 and ILC2s in APC-mutation-mediated colorectal cancer
Interleukin-25 (IL-25) and group 2 innate lymphoid cells (ILC2s) play critical roles in the host immune defense against intestinal parasitic helminth infections, through orchestrating the protective type 2 immune response, eliciting pathogen clearance, and promoting tissue repair. However, IL-25 …
-
Effects of IL-33 on the interaction between HMC-1 cells and human airway smooth muscle cells
… in the world, affecting approximately 300 million people worldwide. Asthma has many phenotypes, allergic asthma being the most common form. Most cases are initiated by IgE antibodies, generally referred to as IgE-mediated allergic asthma. Treatments include β2-agonists and inhaled …
-
Dissecting the anti-allergic potential of carnosic acid during IgE and IL-33-mediated mast cell activation
… with allergy, identifying novel mast cell stabilizing compounds is an area of intense investigation worldwide in an effort to alleviate the severity of the allergy epidemic. Carnosic acid (CA), a major polyphenolic constituent of the Lamiaceae family herbs has been shown to exhibit potent …
-
Immunomodulation in Adenovirus-Induced Viral Hepatitis
… clearance and recovery of liver function to failure to contain the infection and loss of liver function. Because hepatotropic viruses are one of the major etiologic causes of morbidity and mortality worldwide, there is great interest in examining the mechanisms of viral clearance versus …
-
The role of Interleukin-33 in retinal degenerative diseases
… diabetic retinopathy (DR).<br/><br/>Interleukin-33 (IL-33) is expressed in the nuclei of Müller cells in the healthy retina. This cytokine has diverse roles in immunity and inflammation, although its role in Müller cell pathophysiology remains largely unknown. This PhD project has investigated …
-
Dissecting NAMPT Signaling Pathways in Beige Adipocyte Development, Impairment and Maintenance
… adipocyte development, maintenance, and failure remain incompletely defined. Here, I define context-specific functions of NAMPT across aging, obesity, and thermoneutral obesogenic stress. In aging, NAMPT expression declines in smooth muscle actin (SMA)(^+) adipose progenitor cells (APCs) …
-
Investigating the role of MyD88 signalling pathway in immune mediated diseases
… of most of the Toll-like receptor (TLR) family and all the IL-1 receptor family members. Activation of MyD88 dependent signalling is critical for the immune response during infections, however dysregulation of these pathways can contribute to the development of immune mediated …
-
Evaluation of immunomodulatory mediators in chronic obstructive pulmonary disease and cardiovascular disease
… in both COPD and CVD. Firstly, the Interleukin-33 (IL-33)/ST2 axis and secondly, specialised pro-resolving mediators (SPMs), specifically the specialised pro-resolving mediator Resolvin D1. Additionally, data pertaining to the anti-platelet drug aspirin in people with COPD was evaluated. The …
-
Optimizing The Nasal Allergen Challenge Model For The Study Of Allergic Rhinitis
… and biological samples collection. Repeatability of the protocol is key to ensuring unbiased efficacy analysis of novel therapeutics. The effect of allergen challenge on IL-33 gene expression and its relation to IL1RL1 receptor and cytokine secretion was investigated. Methods Several …
-
Ambient particulate matter as a trigger for acute exacerbations of asthma
… via oxidative stress. Objective: To assess the ability of ambient particulate matter to trigger an exacerbation of experimental chronic asthma, in an established mouse model and to explore the mechanism(s) by which this occurs. Methods and Results: BALB/c mice were sensitised to ovalbumin and …
-
Functional and Transcriptional Heterogeneity of the Human Haematopoietic Stem Cell Pool at Steady-State and Under Inflammation
… no erythroid differentiation capacity. Using similar methodologies as above, I report 2 main findings in the human FL HSC/MPP compartment: i) there is a decrease in multipotency and Ery potential with gestational age but an increase in Ly potential and ii) there is an increased percentage of …
-
Roles of γδ T Cells in Influenza Infections and Methods for TCR Expression and Characterization
… pathogen in humans and animals with the ability to cause extensive morbidity and mortality. Exuberant immune responses associated with immune cell migration/activation and cytokine/chemokine release, can be induced after infections. Recent studies have painted a complex picture of viral …
-
Investigation of CD4+ T cell heterogeneity and function in a genetic mouse model of lung adenocarcinoma
… RNA sequencing, we longitudinally profiled conventional CD4+ T (Tconv) and Tregs in an inducible genetic mouse model of lung adenocarcinoma. We show that lung tumor-associated Tregs have a distinct transcriptional signature that is associated with survival in multiple cancers. …
-
ST2 & TLRs: coordination of chemokine-driven immunity
… of TLRs is associated with disease. A family of molecules coded for by the ST2 gene have been implicated as negative regulators of TLR4-signalling in murine cells. Here, the existence and potential role of these ST2 molecules in human macrophages has been investigated. Following the …
-
Immune activation at the lung epithelial barrier
… them to the draining lymph nodes, where they will activate naïve T cells to become effector T cells or regulatory T cells. The outcome of the response depends on the type of antigen, the type of instructing signals encountered in the periphery but also on the nature of the dendritic cell …
-
Astrocytic Sonic Hedgehog signalling in development and disease
… cells (Xie et al., 2022; Farmer et al., 2016; Hill et al., 2019). This adaptation ensures glia that are finely tuned to the specific demands of the neural microenvironment. Indeed, Shh signalling is active only in distinct subpopulations of astrocytes, indicating that Shh may functionally …
-
Inducible Epithelial Resistance Against Acute Viral Pneumonia and Chronic Asthma
… cells at any point of SeV infection showed a similar degree of protection demonstrating Pam2-ODN mediated protection independent of CD8<sup>+</sup> T cell response. Further, Pam2-ODN treatment protected SeV challenged mice from progressing to asthma-like disease by initiating acute anti-viral …
-
Inducible Epithelial Resistance Against Acute Viral Pneumonia and Chronic Asthma
… cells at any point of SeV infection showed a similar degree of protection demonstrating Pam2-ODN mediated protection independent of CD8+ T cell response. Further, Pam2-ODN treatment protected SeV challenged mice from progressing to asthma-like disease by initiating acute anti-viral effects. …
-
Effect of phytoestrogens on breast and prostate cancer cell lines – potential implications for bone metastasis
… and prostate cancer line proliferation, motility, and expression of genes implicated in disease progression and preferential metastasis to the skeleton. The potential modifying effect of cytokines that tumour cells are exposed to in the bone micro environment will also be studied including …
-
Effect of progestin-based hormonal contraceptives on genital inflammation and Th17 cell activation in adolescents at high risk for HIV infection
… Africa, and may offer an improved safety profile over NET-EN and DMPA in terms of HIV risk for young women. Recently, Th17 cells have been found to be disproportionally susceptible to HIV infection compared to the other T helper subsets although the impact of HC use on Th17 cell frequency and …
Page 1 of 2