Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"IL-24"”.
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Splice Factor SFRS6: Regulation by p53 and Effect on IL-24 Splicing
… importance of tight control over this process. While the mechanism of splicing has been described in detail, it is less clear how a cell is able to modify its splicing patterns in response to different conditions. Our lab previously demonstrated that DNA damage can induce <em>SFRS6</em>, the gene …
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Il-2 Regulation of Il-24 Expression Leads to Growth Suppression of Melanoma Cells
… to chemotherapy. Treatment with high dose IL-2 has shown significant clinical benefit in a minority of metastatic melanoma patients and has lead to long term survival in a few cases. However, this treatment is associated with excessive multiorgan toxicities, which severely limits its use. …
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Approaches for Enhancing Therapeutic Efficacy of a Novel IL-10 Gene Family Member: MDA-7/IL-24
… mda-7 gene is now classified as a member of the IL-10 family of cytokines and named IL-24. The mda-7/IL-24 cDNA encodes a protein of 206-amino acids with a predicted size of ~24-kDa, which contains an interleukin (IL)-10 signature motif at amino acids 101–121 (SDAESCYLVHTLLEFYLKTVF) shared by …
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Synergistic growth inhibition and enhancement of cell death by combination of Melanoma Differentiation Associated gene-7 (MDA-7/IL-24) and cisplatin in ovarian cancer cell lines
… melanoma differentiation gene-7 (MDA-7) IL-24, which is a new cytokine, has anti-cancer efficacy by suppressing cell growth and inducing apoptosis in a broad range of tumor cells and does not induce any toxicity in normal cells, thus, making it a potentially effective therapeutic gene for …
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The Molecular Mechanisms Underlying the Cancer Killing Effect of Interleukin-24
<p>Interleukin-24 (IL-24) is an immunomodulatory cytokine that also displays specific anti-tumor effects across many cancer cell types. The tumor suppressor activities of IL-24 include inhibition of angiogenesis, metastasis, toxic autophagy, cancer-specific apoptosis, and sensitization to …
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Small Molecule Inhibitors of MAPK and PI3K Pathways Enhance MDA-7 Lethality in Renal Cell Carcinoma
… gene. This gene encodes for the cytokine MDA-7/IL-24 that has the ability to specifically target transformed cells. Assays performed with this adenovirus resulted in an increased percentage of cell death in renal cancer cells when compared to infection with Ad.5/3-cmv empty vector. Further …
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Novel Cancer Therapeutics, the Generation of ROS, and Cell Survival
… of GST-MDA-7 to inhibit the proliferation, viability, and long-term survival of RCC. We also found that MDA-7 (IL-24), when expressed via a recombinant replication defective adenovirus, Ad.mda-7, exerted anti-proliferative effects on GBM cells, an effect found to be enhanced in a greater than …
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Characterization of Skin Immune Reactions Induced by the Contact Sensitizer Diphencyprone in Healthy Volunteers and Metastatic Melanoma Patients
… be anti-neoplastic effectors, including IFNγ, IL-24, and IL-9. We also examined the potential roles of miRNAs in skin reactions to DPCP, as they may be involved in its therapeutic applications, but are largely unstudied in skin biology and immunology. Furthermore, we used comprehensive T cell …
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Chemical genetic manipulation of interferon regulatory factor 1 (IRF-1) using synthetic biology
… factor 1 (IRF-1), the founding member of IRF family, is a nuclear transcription factor first described as a transcription factor that binds to the upstream region of interferon induced genes following viral infection. In addition, IRF-1 has been reported to be involved in cell growth regulation, …