Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"IL-23"”.
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Effects of Acute Alcohol Exposure on Post Burn Intestinal Immunity: Role of IL-23
<p>More than one million burn injuries are reported yearly within the United States. These injuries result in approximately 500,000 emergency room visits and 40,000 hospitalizations annually. Greater than 50% of these injuries occur under the influence of alcohol/ethanol (EtOH) intoxication. Burn …
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The Role of the IL-23/Th17/IL-17 Axis in the Pathophysiology of Endometriosis
… as dyspareunia, dysmenorrhea, and infertility. Due to invasive diagnosis, disease heterogeneity, and reproductive disorder stigmatization, patients often experience misdiagnosis and significant diagnostic delays. No reliable, non-invasive, non-hormonal therapeutic options exist, …
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IL-23 and IL-27 expression in dendritic cells and the effects of HIV-1
… DC function by downregulating the production of IL-23 and IL-27, cytokines important in the generation of cellular immune responses. Dendritic cells were isolated from the epidermal and dermal skin layers resulting from elective abdominoplasties by CD1a and CD1c microbeads. Circulating DCs were …
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Delineating The Roles of IL-12 and IL-23 Produced by Dendritic Cells in Eliciting CD8+ T Cell Resonses Against Listeria Monocytogenes
Interleukin-12 family members are important links between innate and adaptive immunity. IL-12 drives Th1 responses by augmenting IFN-γ production – key for clearance of intracellular pathogens. IL-23 promotes the development of IL-17 producing CD4+ T cells that participate in the control of …
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DUAL TARGETING OF RFAP AND FIMH IMPAIRS AIEC INTRACELLULAR SURVIVAL AND LIMITS OMV-DEPENDENT IL-23/PTH17 AXIS ACTIVATION, OFFERING A NOVEL THERAPEUTIC STRATEGY FOR CROHN¿S DISEASE
… together with a dysregulated activation of the IL-23/pTh17 axis, is a distinctive feature of CD. In this context, current therapies primarily suppress the exaggerated inflammation without directly targeting AIEC, and the only AIEC-based approach under investigation is the inhibition of FimH, …
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IDENTIFICATION OF ADHERENT-INVASIVE ESCHERICHIA COLI (AIEC) VIRULENCE DETERMINANTS LEADING TO ACTIVATION OF PATHOGENIC TH17 CELLS IN CROHN¿S DISEASE.
… pTh17 trans-differentiation and activation is still totally unknown. To this aim, a library of 10,000 AIEC-LF82 mutants was generated and screened in order to identify AIEC-virulence determinants specifically involved in pTh17 generation, looking for mutants with an impaired ability to trigger …
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Diverse Immune Responses Mediated by Beta-Adrenergic and Corticotropin-Releasing Hormone Receptors in a Model of Pneumococcal sepsis
… lipopolysaccharide (LPS). In addition, the ability of DC to dictate CD4+ T cell activation as a consequence of CRH or epinephrine pre-treatment was examined using an in vitro co-culture system. Epinephrine and CRH pre-treatment resulted in a preferential increase in IL-23 and IL-10 cytokine …
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CONCENTRAÇÕES ELEVADAS DAS CITOCINAS ASSOCIADAS À RESPOSTA Th17 E DESFECHOS DESFAVORÁVEIS EM PACIENTES COM COVID-19 ADMITIDOS À UNIDADE DE TERAPIA INTENSIVA
… been receiving increasing attention due to its ability to modulate inflammation. A prospective inclusion of 56 COVID-19 patients admitted to the Intensive Care Unit (ICU) of the General Hospital of Vitória da Conquista (HGVC) in Bahia, Brazil, was conducted. All included patients had SARS-CoV-2 …
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Neutrophil Regulation of Colitis
… component of the innate immune system, neutrophils are the first responders to sites of inflammation when the intestinal epithelial barrier is breached and gut microbiota invade. Although accumulation of neutrophils in the intestine is correlated with inflammatory bowel disease (IBD), the …
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Aging Dendritic Cell Function and Effects on T Helper Cell Differentiation
… which lead to activation of T cells. The milieu of secreted cytokines determines the differentiation of activated naïve T helper (Th) cells into Th1, Th2, Th17 or T regulatory (Treg) cells. We show that bone marrow-derived DC (BMDC) differentiated from old male mice stimulated with …
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Defining the role of the transcription factor T-bet in the innate immune system in intestinal inflammation.
… mechanisms responsible for causing disease are still to be resolved, yet potentially offer novel insights into the pathogenesis of IBD, and how T-bet might influence inflammation in the gut. <br/>In this thesis it was shown that chronic IBD in TRUC mice was dependent on interleukin-17A (IL-17A) …
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Determination of the role of cytokines using gene deficient mice in African trypanosomiasis infection
… alike. To determine the immunological role of IL=12 family members in Trypanosoma brucei brucei, Trypanosoma evansi and Trypanosoma congolense infections, IL-12p35¯/¯, IL-12p40¯/¯ and IL-12p35¯/¯/p40¯/¯ mice were used. While the two latter mouse strains lack all IL-12 homologues, IL-12p35¯/¯ …
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Psoriasis activation of cells important in cardiovascular disease
… of both diseases. Interleukin-36 cytokines (IL-36) have been heavily implicated in psoriasis immunopathology. Significant upregulation of epidermal IL-36 is a recognised characteristic of psoriatic skin inflammation. IL-36 induces inflammatory responses in dendritic cells, fibroblasts and …
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Expression of Th17 and related cytokines according to clinical activity of Behcet's disease
… of other T cell populations were discovered, and IL(Interleukin)-17 producing Th17 cells were recognized as novel group of T cells which play a major role in autoimmunity. A recent study has shown elevated production of IL-17, IL-23, and IFN (Interferon)-γ by peripheral blood mononuclear cells …
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Modulation of macrophage and epithelial cell immune defences by probiotic bacteria: immune stimulation versus suppression
… cytokine suppression, and augmentation of IL-10 production in the gut relate to endotoxin tolerance. Endotoxin tolerance is a context; it could present an example for cell drive through a hypo-responsive state. An example is mu-cosal inflammatory pathologies, such as Crohn’s disease. When …
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Discovery of macrocyclic inhibitors of challenging protein-protein interactions
… their high binding affinity and membrane permeability, enabling the discovery of orally delivered and efficacious therapeutics. Recent methods have enabled the purification-free synthesis of chemically diverse macrocycles and the generation of de novo libraries for high-throughput screening and …
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Tailored influenza virus vaccines for both the young and old: Vaccine Efficacy of Whole Inactivated Vaccines bearing Immunomodulatory Adjuvants or Multimeric peptides
… in the elderly and immunocompromized and the inability to protect against antigenically drifted or shifted strains of influenza virus are the two major problems in influenza vaccine research. To overcome these hurdles, we have utilized an in vitro cell culture vaccine platform, which results in …
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Η θεραπεία της ψωρίασης με βιολογικούς παράγοντες και μικρά μόρια την εποχή της πανδημίας Covid-19
… παραγόντων, όπως οι αναστολείς του άξονα IL-23 και IL-17, καθώς και οι αναστολείς του TNF, και αναλύονται η αποτελεσματικότητα, η ανεκτικότητα και η διατήρηση της ανταπόκρισης σε πραγματικές συνθήκες. Παρουσιάζονται επίσης τα μικρά μόρια με κυριότερη την από του στόματος θεραπεία που …
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SKIN COMMENSAL STAPHYLOCOCCUS PROMOTES SYSTEMIC V-GAMMA-6 GAMMA-DELTA T CELL RECONFIGURATION
… skin colonization promotes a robust expansion of IL-17A-producing Vγ6⁺ γδT cells both locally in the dermis and systemically in lymphoid, mucosal, metabolic and central nervous system tissues. This systemic reconfiguration is IL-1R-dependent but independent of IL-23 receptor signaling and the …
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Transcriptional Regulation of T Helper Cell Differentiation in Autoimmunity
… T helper cells in the EAE model. Based on its ability to induce a pro-inflammatory immune response, T-bet has been found to regulate genes that have been directly linked to pathogenicity in EAE/MS. We examined the use of T-bet specific AS oligonucleotides and siRNA to silence T-bet expression in …
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