NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 20 of 35 for “"IL-22"”.

  1. Functional Characterization of the Avian Inflammatory Mediators Nod1, MIF and IL-22

    Kim, SungwonVirginia Tech2011

    … that the presence of rChMIF enhanced levels of IL-1β and iNOS during monocytes stimulation with LPS. Additionally, Con A-stimulated lymphocytes exhibited enhanced IFN-γ and IL-2 transcripts in the presence of rChMIF. IL-22, which may act as a signal regulator, is an important effector of …

    vt Repository record

  2. Gene expression in synovial fibroblasts from rheumatoid arthritis and osteoarthritis patients Novel expression of IL-19 and IL-22 by fibroblasts

    MacDonald, Daniel FrancisUniversity of Ottawa (Canada)2013

    … two pro-inflammatory cytokines belonging to the IL-10 family of cytokines, IL-19 and IL-22, are constitutively expressed in cultured FLS, and this expression was independent of length of culture. The other work in this thesis focused on identifying potential cytokine receptors expressed in FLS …

    ottawa-retro Repository record

  3. Characterization of Mycobacterium tuberculosis-specific Th22 cells in HIV-TB co-infection

    Makatsa, Mohau StevenDivision of Medical Virology2020

    … greatest global mortality, with an estimated 10 million incident cases of TB and 1.45 million deaths in 2018. Although there is a cure for TB, the success of the treatment is hampered by multidrug resistant TB and HIV infection. There is an urgent need for an effective TB vaccine to prevent …

    cape-town Repository record

  4. Determinação de citocinas da via TH17 e da atividade imunomoduladora do novo derivado Tiazolidínico LPSF/TM17, agonista do PPARy, em células do sangue periférico de pacientes portadores de artrite reumatoide

    ROCHA JÚNIOR, Laurindo Ferreira daUniversidade Federal de Pernambuco2013

    … níveis de citocinas da via Th17, particularmente IL-17A e IL-22 e correlacionar seus níveis séricos com dados clínicos, demográficos, radiológicos e laboratoriais de pacientes com AR, bem como avaliar a atividade imunomoduladora do novo derivado tiazolidínico LPSF/TM17. Os pacientes foram …

    brazil-ufpe Repository record

  5. The Role of Interleukin-10 Family Members in Inflammatory Skin Diseases. Understanding the mechanism of action of interferon lambda and interleukin-22 on human primary keratinocytes and dermal fibroblasts with a focus on healing responses in inflammatory skin diseases

    Alase, Adewonuola A.University of Bradford2015

    … role in scar formation in chronic discoid CLE. IL-22 activates STAT3 and it is emerging as a mediator with significant impact on normal wound repair, epidermal hyperproliferation and prevention of fibrosis. This work focussed on understanding the regulation and functional impact of IL-22 and …

    bradford Repository record

  6. Effects of Acute Alcohol Exposure on Post Burn Intestinal Immunity: Role of IL-23

    Rendon, Juan L.1970

    <p>More than one million burn injuries are reported yearly within the United States. These injuries result in approximately 500,000 emergency room visits and 40,000 hospitalizations annually. Greater than 50% of these injuries occur under the influence of alcohol/ethanol (EtOH) intoxication. Burn …

    loyola-thes Repository record

  7. Innate Interleukin-17 and Interleukin-22 play important roles in viral hepatitis

    Jie, ZuliangThe University of Texas Medical Branch at Galveston2016

    Intrahepatic cell-derived IL-17 and IL-22 are important for T cell priming and hepatoprotection in viral hepatitis, respectively; however, the source and regulation of these cytokines in the liver microenvironment are not well defined. Here, we present evidence for a significant expansion of IL-17- …

    utmb Repository record

  8. Investigating cytokine responses to different strains of Mycobacterium tuberculosis

    Booi, ZandileDepartment of Clinical Laboratory Sciences2021

    … differences in the adaptive immune response (IL-22 and IL-17) induced by various Mtb strains, however these differences have not been clearly defined. The aim of this study was to investigate CD4+ T cell adaptive cytokine responses (IFN-γ, IL-22 and IL-17) in blood from human volunteers with …

    cape-town Repository record

  9. TRYPTOPHAN-DERIVED MICROBIAL METABOLITES PROMOTE NKT22 PRO-TUMORIGENIC FUNCTIONS IN COLITIS ASSOCIATED COLORECTAL CANCER PATIENTS

    PERILLO, FEDERICAUniversità degli Studi di Milano2025

    … IBD have an elevated risk of developing CAC. IL-22, a cytokine involved in epithelial cell proliferation and survival, is also linked to tumor formation. It is secreted by various immune cells, including tissue-resident iNKT cells. In IBD, iNKT cells exhibit either pro-inflammatory or …

    milano Repository record

  10. Neutrophil Regulation of Colitis

    Chen, FeidiThe University of Texas Medical Branch at Galveston2021

    … component of the innate immune system, neutrophils are the first responders to sites of inflammation when the intestinal epithelial barrier is breached and gut microbiota invade. Although accumulation of neutrophils in the intestine is correlated with inflammatory bowel disease (IBD), the …

    utmb Repository record

  11. The development of a liposomal form Secukinumab – an IL 17 pathway inhibitor in the treatment of psoriasis

    Layas, Gazala I.University of Bradford2022

    … effects, is Secukinumab. Secukinumab is an anti-IL17 antibody that works by stopping the action of IL17, a cytokine that is known to have a major role in the pathogenesis of psoriasis. This work is based on the development of a new way to commence drug therapy to reduce the side effects of the …

    bradford Repository record

  12. The development of a liposomal form Secukinumab – an IL 17 pathway inhibitor in the treatment of psoriasis

    Layas, Gazala I.University of Bradford2022

    … effects, is Secukinumab. Secukinumab is an anti-IL17 antibody that works by stopping the action of IL17, a cytokine that is known to have a major role in the pathogenesis of psoriasis. This work is based on the development of a new way to commence drug therapy to reduce the side effects of the …

    bradford Repository record

  13. Regulatory Immune Responses and Repair Mechanisms in Atherosclerosis

    Rattik, SaraExperimental Cardiovascular Research Unit, Lund University2015

    … in atherosclerosis. In paper IV, we show that IL-22 is involved in controlling smooth muscle cell phenotype. More specifically, IL-22 deficient atherosclerotic mice develop smaller plaques with increased expression of contractile proteins. Increased numbers of smooth muscle cells remaining in a …

    lund Repository record

  14. Investigating the role of IgG and Fcγ receptors in intestinal inflammation

    Castro Dopico, TomasUniversity of Cambridge2018

    … genetic variation in Fcγ receptors (FcγRs), a family of receptors that mediate immune cell activation by IgG, influences susceptibility to inflammatory bowel disease (IBD), suggesting that IgG may be important during gut inflammation. IBD is a chronic relapsing condition with two major subtypes, …

    cambridge Repository record

  15. Innate memory to bacterial infection

    Inacio, NeusaQueen's University Belfast2021

    The innate lymphoid cells (ILCs) ILC1, ILC2, and ILC3, which also includes the natural killer (NK) cells are important regulators and first line responder during pathogen invasion. The role of ILCs was evaluated using FACS sorting, cytokine production and surface markers analysis, cell depletion, …

    qu-belfast Repository record

  16. The Effect of Endocytosis of Interferon-lambda and The Genotype of IL-10RB on The Cellular Responses to Cytokines

    조, 옥기2011

    … IFN-의 endocytosis pathway에 대하여 조사하고자 하였다. 다음으로, IL-10R2의 E47 allele가 HBV clearance와 관련됨이 Gambian을 대상으로 한 SNP연구에서 보고되었다. IL-10R2를 수용체로 이용하는 사이토카인 중 IFN-R와 IL-22R1은 간세포에서 발현되며, 바이러스 증식을 억제함이 연구 되었다. 그러나, IFN-와 IL-22의 반응성에 IL-10R2 유전자형이 미치는 영향에 대해서는 조사되지 않았다. 따라서, IL-10R2 유전자형에 따른 IFN- 또는 IL-22의 …

    ajou Repository record

  17. Identification and characterisation of Group 3 Innate Lymphoid Cells in the renal tract

    Riding, Alexandra MaryUniversity of Cambridge2019

    Innate lymphoid cells (ILCs) bear similarities to T-helper (Th) cells, but lack T cell receptors. The three groups mirror the effector functions of Th1, Th2 and Th17 cells and share the same transcription factors and cytokine profiles. This project focussed on type 3 ILCs (ILC3s) found primarily at …

    cambridge Repository record

  18. Exploring the role and the function of Aryl Hydrocarbon Receptor (AhR) and Aryl Hydrocarbon Nuclear Translocator (ARNT) in T cells

    Rosenzweig, EllaUniversity of Dundee2012

    … seems to be critical for the production of the IL-22 cytokine. It is known that AhR ligands such as dioxins can suppress CD8 T cell mediated antiviral immune responses but it is not known whether this reflects a direct role of the AhR in CD8 T cells. <br/>Accordingly, one objective of the …

    dundee Repository record

  19. Characterisation of the anti-inflammatory potential of ES-62 in autoimmune disease

    McGrath, Mairi AnneUniversity of Glasgow2010

    Filarial nematode infections remain a significant threat of morbidity in the Tropics. Collectively known as filariasis, these helminth infections can result in gross inflammatory pathology of the infected host. However, more commonly, the host remains relatively asymptomatic, exhibiting a somewhat …

    glasgow

  20. Studies on the differentiation of inflammatory and regulatory T-cells

    Jeffery, Louisa ElizabethUniversity of Birmingham2012

    … T-cells, suppressing inflammatory cytokines (IL-17, IL-21, IFN\(_y\) and IL-22) whilst enhancing regulatory markers (CTLA-4, CD25, FoxP3 and IL-10). Consistently, 1,25(OH)\(_2\)D\(_3\)-treated T-cells suppressed division of naive T-cells stimulated by dendritic cells (DCs). Strong …

    birmingham Repository record

Page 1 of 2