Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"IL-2 receptor"”.
-
Protein engineering for cancer therapy
… a novel class of engineered Interleukin-2 (IL-2) analogues that antagonize the IL-2 receptor, for inhibiting Treg suppression. These antagonists are engineered for high affinity to the IL-2 receptor a subunit and low affinity to either the [beta] or [gamma] subunit, resulting in a …
-
Analysis of trafficking dynamics and cellular response in the interleukin-2 ligand/receptor system
Interleukin-2 (IL-2) has been widely studied as a protein therapeutic due primarily to its central role in potentiating cell-based immunity. The effects of IL-2 on its cellular targets are mediated solely through interaction with one or more forms of the IL-2 receptor (IL- 2R). The overall goal of …
-
Low-dose IL-2 for T-regulatory cell expansion after alemtuzumab therapy in relapsing-remitting multiple sclerosis
… optimally. Their expression of the high-affinity IL-2 receptor, containing the CD25 subunit, renders them 10-fold more sensitive to IL-2 than effector cells (Teffs). Low-dose IL-2 preferentially expands Tregs in patients with a variety of autoimmune disease, correlating with clinical improvement. …
-
IL-2-Dependent Regulation of Immune Homeostasis and Response to Infection
Interleukin-2 (IL-2) is a critical regulator of immune homeostasis through its impact on both regulatory T (Treg) and effector T (Teff) cells. However, the precise role of IL-2 in the homeostatic maintenance and function of Treg cells in the adult peripheral immune system remains unclear. Here, we …
-
The effects of vitamin A deficiency on the immune system in a murine model of systemic lupus erythematosus
… assigned to either the A$-$ or A+ groups, while twenty-four +/+ mice, of the same sex and age range as MRL/l, were assigned to the normal control group (+/+ group). The results of both studies showed that vitamin A deficiency had a significant effect on preventing the MRL/l mice body weight …
-
Il-2 Regulation of Il-24 Expression Leads to Growth Suppression of Melanoma Cells
… to chemotherapy. Treatment with high dose IL-2 has shown significant clinical benefit in a minority of metastatic melanoma patients and has lead to long term survival in a few cases. However, this treatment is associated with excessive multiorgan toxicities, which severely limits its use. …
-
Two investigations in molecular pathophysiology
… many previous workers have examined the ability of growth-factor antagonists to inhibit the growth of the cells of human leukemias and of animal leukemia models, none have documented the complete blockage of growth, and none have documented the death of such cell populations. A model of …
-
Development Of Regulatory T Cells Capable Of Maintaining Immune Homeostasis
… of the adaptive immune system relies on the ability to discriminate self from non-self-antigens. The thymus is the site of selection for T cells, where self-reactive T cells are eliminated, generating a non-self focused T cell compartment. However, this selection process is leaky and …
-
Investigating the antibody-independent functions of B lymphocytes
… during Gram-negative sepsis, inducing neutrophil expansion and mobilisation to limit bacteraemia. B cells can also regulate immune responses via the production of cytokines such as IL-10, and this can inhibit deleterious autoimmune and alloimmune responses in murine models. Here I investigated …
-
Spezifische Zytokinmuster und Schrankenstörung bei interstitiellen Lungenkrankheiten
… Schwerpunkt der Untersuchungen bezogen sich auf IL-2 Rezeptor, IL-8 und Lysozym in bronchoalveolaerer Lavagefluessigkeit (BALF) und Serum bei Patienten mit Sarkoidose, Exogen-allergischer Alveolitis (EAA) und interstitieller Lungenfibrose (IPF). Unbehandelte Sarkoidosepatienten hatten über den …
-
The Development and Function of Memory Regulatory T Cells
… the cell surface markers CD25, as known as the IL-2 receptor alpha chain, glucocorticoid-induced tumor necrosis factor receptor (GITR), and cytotoxic T-lymphocyte antigen-4 (CTLA-4), as well as forkhead box P3 (Foxp3), a transcription factor considered to be the most specific TReg marker. …
-
The effects of honey on the inflammatory response of cells with respect to wound healing
… resting T cells to proliferate and express the IL-2 receptor in a dose-dependent manner with progressive dilution. This suggests that honey contains lymphomitogenic factors. Manuka honey was stimulatory at higher dilutions than pasture honey. Low concentrations of honey induced cell division …