Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 252 for “"IL-2"”.
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Kostnaðarvirknigreining á árangri nýrnakrabbameinslyfsins IL-2
… notkun á nýrnakrabbameinslyfinu Interleukin 2. Til þess að meta það verður notast við kostnaðarvirknigreiningu. Ritgerðinni er skipt niður í nokkra kafla. Fyrsti kaflinn er inngangurinn. Annar kafli fjallar almennt um krabbamein. Í þriðja kafla eru taldir upp áhættuþættir krabbameins og forvarnir …
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IL-2-Dependent Regulation of Immune Homeostasis and Response to Infection
Interleukin-2 (IL-2) is a critical regulator of immune homeostasis through its impact on both regulatory T (Treg) and effector T (Teff) cells. However, the precise role of IL-2 in the homeostatic maintenance and function of Treg cells in the adult peripheral immune system remains unclear. Here, we …
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Cd44-Hyaluronic Acid Interactions in Il-2 Induced Vascular Leak Syndrome
Immunotherapy with IL-2 is accompanied by severe toxicity leading to development of vascular leak syndrome (VLS). Previous studies from our laboratory demonstrated that CD44 knockout mice exhibit marked decrease in IL-2 induced VLS, thereby suggesting a role for CD44 in VLS. In the current study we …
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Vaccinia Virus-Mediated Glioma Gene Therapy Using p53, IL-2 and IL-12
… combining immunotherapy with interleukin (IL)-2 and interleukin (IL)-12 and a tumor suppressor (p53). We propose the <em>hypothesis</em> that this specific combination of therapeutic genes has a synergistic inhibitory effect on glioma growth and describe a <em>mechanism</em> to account for …
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Quantitative analysis of IL-2 and IL-15 signal transduction in T lymphocytes
IL-2 and IL-15 are common y-chain family cytokines critically involved in regulation of T cell differentiation and homeostasis. Both cytokines signal through a heterotrimeric surface receptor complex (IL-2/15R) composed of an [alpha], a [beta], and the common gamma ([gamma]c) chain. Signaling …
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Il-2 Regulation of Il-24 Expression Leads to Growth Suppression of Melanoma Cells
… to chemotherapy. Treatment with high dose IL-2 has shown significant clinical benefit in a minority of metastatic melanoma patients and has lead to long term survival in a few cases. However, this treatment is associated with excessive multiorgan toxicities, which severely limits its use. …
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Combination Therapy With Aerosol Il-2 and Nk Cells For The Treatment of Osteosarcoma Lung Metastasis
… to evaluate the efficacy of combining natural killer [NK] cell therapy with aerosol interleukin-2 [IL-2] for the treatment of osteosarcoma lung metastasis. The expression of NKG2D ligands was analyzed in five different human osteosarcoma cell lines and 103 patient samples (47 from primary tumors …
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Cytokine-capture nanoparticles to quantify IL-2 concentrations within the immunological synapse during T cell activation
The feasibility of bringing a nascent technology for detection and quantification of local cytokine concentrations on cell surfaces to market is presented in this paper. Quantum dots or fluorochrome-loaded nanoparticles are conjugated with antibodies for target analytes and with proteins that allow …
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Identification and analysis of Il-2 induced Stat5 Target genes in Human CD4 and CD8 T cells
… activated by the cytokine interleukin-2 (IL-2), and therefore critically regulates<br/>important immunological processes such as T cell homeostasis and immune-regulation.<br/>While the biological functions of STAT5 are well established from murine genetic<br/>studies, the downstream …
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Low-dose IL-2 for T-regulatory cell expansion after alemtuzumab therapy in relapsing-remitting multiple sclerosis
… optimally. Their expression of the high-affinity IL-2 receptor, containing the CD25 subunit, renders them 10-fold more sensitive to IL-2 than effector cells (Teffs). Low-dose IL-2 preferentially expands Tregs in patients with a variety of autoimmune disease, correlating with clinical improvement. …
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IL-2 and Antisense TGF-B1 Gene Therapy of the H238 Tumor and Analysis of TGF-B Receptors
… growth factor-beta (TGF-p) belongs to a family of immunosuppressive cytokines, capable of regulating macrophages, T, B and NK cells. We have detected the TGF-p transcript being synthesized by H238 cells. This is herpes simplex-Type2 transformed murine fibrosarcoma cell line. The amount of …
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Herstellung und funktionelle Analyse von Immunzytokinen, die Interleukin-2 (IL-2) oder Granulozyten/Makrophagen Kolonie-stimulierenden Faktor (GM-CSF) enthalten, zur Verbesserung einer NDV-modifizierten Tumorvakzine
… und funktionellen Analyse neuartiger, IL-2- bzw. GM-CSF-enthaltender bi- und trispezifischer single-chain Antikörper (Immunzytokine) zur Verbesserung der antitumoralen Immunantworten bei Krebspatienten. Die Arbeit ist thematisch in ein Projekt zur Entwicklung einer aktiv-spezifischen …
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Analysis of trafficking dynamics and cellular response in the interleukin-2 ligand/receptor system
Interleukin-2 (IL-2) has been widely studied as a protein therapeutic due primarily to its central role in potentiating cell-based immunity. The effects of IL-2 on its cellular targets are mediated solely through interaction with one or more forms of the IL-2 receptor (IL- 2R). The overall goal of …
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Engineering persistent interleukin-2 for cancer immunotherapy
Mobilizing the immune system to recognize and destroy tumor cells is a promising strategy for treating cancer. In contrast to standard therapeutic approaches such as surgery, radiation, and chemotherapy, immunotherapy offers the possibility of systemic yet tumor-specific cell killing as well as …
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Type I Interferon Signaling Pathway May Be Involved in Optimal Interleukin-2 Production in CD4+ T Cells
… by positively regulating interleukin-2 (IL-2) expression, a hallmark cytokine of central memory CD4⁺ T cells. The present work seeks to delineate how signaling through the interferon alpha/beta receptor promotes IL-2 secretion in murine CD4⁺ T cell. IL-2 provides an essential growth …
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Harnessing the manufacturing power of the plant system : production of recombinant human interleukin-2 in Nicotiana benthamiana
… In this thesis, I have explored the feasibility of producing recombinant human interleukin-2 (IL-2) in the green tissues of transgenic Nicotiana benthamiana (tobacco). IL-2 is a biopharmaceutical of great importance as it is the standard immunotherapeutic treatment for late-stage metastatic …
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Interleukin-2 Engineering for improved therapeutic effectiveness
… for its private alpha receptor subunit, unlike wild-type IL-2 (K[d] [approximately] 10 nM). IL-2 mutants with picomolar affinity for IL-2Rα stimulate T cell growth responses quantitatively equivalent to those mediated by IL-15. Our results suggest that the contrasting effects of IL-2 and IL-15 on …
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Immunotherapeutic alteration of tumor-induced suppression of interleukin 2 and 3 production by Propionibacterium acnes vaccination
… investigated the involvement of Interleukin 2 (IL 2) and Interleukin 3 (IL 3), known components of the Interleukin cascade, in local P. acnes-mediated anti-tumor action. A 500 ug dose of heat-killed stationary phase P. acnes given simultaneously with 10⁴ tumor cells was found to inhibit tumor …
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