Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"IL-1ra"”.
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The Effect of Obesity on IL-1β, IL-1Ra, and Leptin Following Acute Mental Stress
… Specifically, this study aims to address IL-1β, IL-1Ra, and leptin following an AMS task in non-obese and obese individuals. Additionally, a manuscript is included which evaluates the change in IL-1β, IL-1Ra, and leptin following a 20 minute AMS task. Variables were examined between groups …
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The effect of fasting on anti-inflammatory mediators, IL-1RA and IL-1R2, and their role in resistance to sickness behaviors in mice
… (24 h water-only fast) is able to attenuate IL-1β-induced anorexia, in addition to other sickness behaviors at early stages of the acute phase response. We previously reported that fasting was able to reduce gene expression of inflammatory IL-1α in the brain, here we looked at liver and …
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Roles of interleukin-1 beta in glutamate-induced spinal cord injury
… toxicity involving activation of interleukin-1â (IL-1â). To assess the effects of glutamate on IL-1â and its natural blocking agent interleukin-1 receptor antagonist (IL-1ra), ELISA assays were used to measure the responses of endogenous IL-1â and IL-1ra to glutamate administered to the spinal …
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Interleukin-1 receptor antagonist delivery through adenoviral mediated gene transfer as a treatment for equine joint disease
The interleukin-1 (IL-1) system is a small group of cytokines composed of two agonist proteins and a receptor antagonist (IL-1Ra). The action of the IL-1 system is mediated through binding of these ligands to the IL-1 receptors. Binding of the IL-1Ra protein to IL-1 receptors has not been …
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Immunological and behavioral consequences of high-fat diet feeding in mice
… that obese mice fed a high-fat diet (HFD), fail to exhibit an interest in saccharin (27% vs 74%) compared to mice fed a low-fat diet (LFD) (p < 0.007). When HFD mice undergo a fasting period of 24 hours, saccharin preferences equilibrate to water consumption (51% saccharin vs 49% water). Other …
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Self-assembling polymeric nanoparticles for enhanced intra-articular anti-inflammatory protein delivery
… that a controlled release/presentation system will more effectively deliver anti-inflammatory protein therapies to the OA joint. The primary goal of this work was to synthesize a block copolymer that could self-assemble into injectable, sub-micron-scale particles and would allow an …
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Long-term effects of LPS and high-fat diet on dopaminergic neurodegeneration
… In the current study, it is hypothesized that IL-1 beta, a potent proinflammatory cytokine synthesized and released by glia cells, could be mediating the LPS-induced dopaminergic neurodegeneration and that the chronic low-grade inflammatory state caused by diet-induced obesity would exacerbate …
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Long-term effects of LPS and high-fat diet on dopaminergic neurodegeneration
… In the current study, it is hypothesized that IL-1 beta, a potent proinflammatory cytokine synthesized and released by glia cells, could be mediating the LPS-induced dopaminergic neurodegeneration and that the chronic low-grade inflammatory state caused by diet-induced obesity would exacerbate …
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Klonierung und Charakterisierung des Interleukin-1beta-Systems im Gehirn von Callithrix jacchus
… Sequenzen) der einzelnen Interleukin-1 (IL-1) Systemkomponenten im Gehirn von C. jacchus entwickelt werden. Damit gelang auch ein Nachweis der IL-1 Systemkomponenten unter basalen Bedingungen. Mit Hilfe der Technik der in-situ-Hybridisierung und der Immunhistochemie konnte erstmals ein …
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Cytokine and Growth Factor Concentrations in Canine Autologous Conditioned Serum
… was to compare growth factor and cytokine profiles in canine autologous conditioned serum (ACS) to canine plasma. Blood collected from 16 medium to large breed dogs was used to produce ACS (Orthokine® vet irap 10 syringes) and citrated plasma (control). Canine-specific ELISA assays were run per …
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Genetic Exploration of Hereditary Immune Diseases
… the gene expression levels to change which fail to properly regulate the body's functions, resulting in immune system diseases. I used existing mouse models to improve the understanding of these two diseases.</p> <p>The first study concerns Arthritis (Chapter 2). This study has been designed …
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IL-1 activation of NF-kB contributes to perinatal hypoxia/ischemia induced cell death
IL-1 activity has been implicated in perinatal hypoxia/ischemia (HI) brain damage without the underlying mechanisms being characterized. We used a 7-day-old rat model to elucidate the role of NF-kB in HI stimulation of IL-1 signaling. HI was induced by permanent ligation of the left carotid artery …
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Differenzierungsabhängige Modulation der Zytokin- und Chemokinexpression bei humanen myeloischen Zell-Linien
… <br>linienspezifische Zytokin- und Chemokinprofile bestimmt werden. <br>Ebenfalls sollte untersucht werden, ob eine Korrelation zwischen Phänotyp und Zytokin-/Chemokinexpressionsmuster besteht. Bei undifferenzierten und differenzierten Zellen wurde ein intrazellulärer immunzytologischer …
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Temporal profile of blood cytokine levels and placental pathology in extremely preterm infants
… between placental pathology and the temporal profiles of “cytokine” (cytokines, chemokines and growth factors) levels in extremely preterm infants. Study design: A prospective cohort study of preterm infants born before 29 weeks gestational age (GA) and admitted to the neonatal intensive care unit …
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The Association Between Cancer-Related-Fatigue, Response to Fatigue Treatment, and Cytokines and Their Receptors, In Patients With Advanced Cancer
… were assessed by FACIT-F, ESAS; serum cytokines [IL-1β and receptor antagonist (IL-1RA), IL-6, IL-6R, TNF-α and sTNF-R1 and R2, IL-8, IL-10, IL-17] levels measured by Luminex. Data were analyzed using principal component analysis (PCA) [reporting cumulative variance (variance) for the first four …
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Sex Differences in Heat Shock Protein 72 Expression and Inflammatory Response to Acute Exercise in the Heat.
… VO2max 60 ± 7 ml/kgFFM/min) completed 2 treadmill bouts at 60% VO2max for 60 min in a 42°C, 20% RH environment. The W had normal menstrual cycles and were tested in counterbalanced order during follicular (fol) and luteal (lut) phases. M and Ws duplicate trials were separated by 12 ± 2 days. …
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Conjugated Linoleic Acid in the treatment of murine autoimmune glomerulonephritis
… disease progression. Treatment with CLA reduced IL-6 production in cultured mesangial cells, but not in siRNA-treated mesangial cells, supporting a PPAR-γ-mediated mechanism. CLA treatment increased both Transforming Growth Factor (TGF-β) and Interleukin-1 Receptor Antagonist (IL-1RA) mRNA …
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Investigating the link between post-tuberculosis lung disease (PTLD) and circulatory biomarkers in a South African cohort
… agent, despite being preventable and curable. While global health efforts have significantly improved diagnostic and therapeutic strategies, emerging evidence demonstrates that many patients experience long-term pulmonary complications after completing TB treatment. These complications are …
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Der Interleukin-1-Genkomplex in der Schizophrenie
Es gilt heute als gesichert, dass eine starke genetische Komponente in der Ätiologie der Schizophrenie vorliegt. In der vorliegenden Arbeit wurden in einer Fall-Kontroll-Assoziationsstudie drei genetische Polymorphismen in Genen des Interleukin-1-Genkomplexes auf eine mögliche Assoziation mit …
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Describing the immune cell profile of ventricular cerebrospinal fluid (CSF) in paediatric central nervous system (CNS) infections
… with high mortality rates and neurological disability in survivors due to brain injury caused by cerebral inflammation. Because the brain is difficult to study, the unique characteristics of the neuroinflammatory response are poorly understood. A better understanding of the immune response to …
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