Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"IL-1beta"”.
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The effect of cannabinoids on IL-1beta induced catabolic pathways in osteoathritic chondrocytes.
… osteoarthritis (OA) is the loss of articular cartilage. Cartilage breakdown is mediated by complex interactions of proinflammatory cytokines such as interleukin 1beta (IL-1beta) and proteases including matrix metalloproteinases (MMPs). Cannabinoids have been shown to reduce joint damage in animal …
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Extracullular Atp Regulates Il-1beta Release From Microglial Cells Via Purinergic Receptor After In Vitro Trauma
… Current literature suggests that interleukin-1Beta is an important cytokine mediator, which is dramatically increased after brain injury. Previous studies indicate that ATP is released by traumatically injured astrocytes and serves as a cell-to-cell mediator through purinergic receptors after …
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Detection of glial interleukin-6 release: Development of a novel interleukin-6 Elisa
The development of an interleukin-6 (IL-6) enzyme-linked immunosorbent (ELISA) assay resulted in a detection range of 1 ng/m1 to 10 ng/mL IL-6. The limit of detection (LOD) for IL-6 was 0.25 ng/mL. Troubleshooting techniques were attempted including matrix effects, non-specific binding, and coating …
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Regulation of Insulin and CHOP Gene Expression in Pancreatic Beta Cells
… not alter its nuclear localization, protein stability, or apparently its DNA binding to the insulin promoter in beta cells. These studies suggest that MafA sumoylation modulates gene transcription in beta cells. In type I diabetes, beta-cell apoptosis is the major reason for immune-mediated …
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Modulators of Inflammation and Steroid Receptors Regulate Proteinase Inhibitor 9 Gene Expression
… receptor (GR) complex inhibited IL-1beta induced PI-9 gene expression but IL-1beta did not interfere with dexamethasone induction of PI-9. Glucocorticoid administration resulted in reduced p65 binding to a consensus NF-kappaB element. To investigate the mechanism of crosstalk …
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Neuroinflammation and Cognitive Impairment in the Aged: Implications for Nutritional Intervention
… of inflammatory cytokines such as interleukin (IL)-1beta within the brain is proposed to underlie acute cognitive disorders in elderly individuals with a viral or bacterial infection. In initial studies behavioral deficits in aged mice were exaggerated after either peripheral administration of …
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Induction of Interleukin-1(beta) Converting Enzyme in the Brain and Its Role in Anorexia Induced by Centrally Administered Lipopolysaccharide
Precursor interleukin-1beta (IL-1beta) is cleaved by interleukin-1beta converting enzyme (ICE) to generate the biologically active form of IL-1beta. Interleukin-1beta synthesized in the brain is thought to be involved in the induction of sickness behavior by lipopolysaccharide (LPS). In the first …
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Klonierung und Charakterisierung des Interleukin-1beta-Systems im Gehirn von Callithrix jacchus
… Sequenzen) der einzelnen Interleukin-1 (IL-1) Systemkomponenten im Gehirn von C. jacchus entwickelt werden. Damit gelang auch ein Nachweis der IL-1 Systemkomponenten unter basalen Bedingungen. Mit Hilfe der Technik der in-situ-Hybridisierung und der Immunhistochemie konnte erstmals ein …
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Metabolic alterations in patients with self-inflicted aggressive behaviour
… role of leptin, insulin, glucagon, glucose and IL-1beta in the context of self-inflicted aggressive behaviour. We used cerebrospinal fluid (CSF-) samples from patients with a recent suicide attempt and plasma samples from a five-hour oral glucose tolerance test (OGTT) in women with deliberate …
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Cytokines and human endometrial function: Abnormalities in recurrent miscarriage women.
… The role of cytokines in the human endometrium still remains to be determined, but they are thought to play an important role in the implantation process. This study has therefore focused on the expression of pro-inflammatory cytokines in the human endometrium and effects of these cytokines on …
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Cytokine and neurotransmitter regulation of glial cell production of Il-6; indications for neurodegenerative disorders
The cytokines interleukin-1 (IL-1) and interleukin-6 (IL-6) are produced during an immune reaction and cause inflammation and swelling of the surrounding tissue. AD is a neurodegenerative disorder characterized by well-defined neuropathologic entities. Both IL-1 and IL-6 are present in senile …
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Aging Exacerbates the Brain Response to a Peripheral Immune Stimulus
… periphery to produce pro-inflammatory cytokines (IL-1beta, IL-6, and TNFalpha) that convey a message to the brain to stimulate microglia and elicit sickness behaviors. However, excessive or prolonged release of cytokines can cause severe behavior deficits and neurotoxicity. Because neurobehavioral …
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Cytokine patterns in a comparative model of arenavirus infection: Implications for virulence and control of viral replication
… Low passage Pichinde virus (P2) induces a mild disease with low viremia, while high passage Pichinde (P18) induces a severe disease with high viremia, ending in terminal shock. We hypothesized that severe disease would be associated with a suppression of potentially antiviral cytokines early …
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Mechanisms of Cytokine-Induced IGF -I Insensitivity in Cancer Cells
… necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6), inhibit IGF-I-promoted DNA synthesis in human MCF-7 breast adenocarcinoma cells, T-47D breast ductal carcinoma cells, murine FDCP progenitor myeloid cells and human promyeloid HL-60 cells. Flow cytometry …
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Type 2 Diabetes Impairs Interleukin-4 Function in Macrophages and Amplifies the Brain-Based Neuroimmune Response
… Disruption of intracellular signaling pathways utilized by cytokines and augmentation of macrophage responses to cytokines or infectious agents, as a result of type 2 diabetes, may play a critical role in disrupting the neuroimmune response. This literature review focuses on neuroimmune …
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Aging Delays and Exercise Accelerates Wound Healing and Decreases Inflammation in Old Mice
… group. EX mice were run on a motorized treadmill at a moderate intensity for 30 minutes/day for eight days, three days before wounding, and five days afterwards. Mice were given four full thickness dermal wounds using a 3.5mm punch biopsy instrument and wounds were photographed for 10 days. …
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Phosphatidylinositol 4-phosphate 5-kinase Involved in Neuroglial Toll-like Receptor Signaling
… brain, have essential roles in the immune surveillance of the central nervous system. Activation of Toll-like receptor 4 (TLR4), the primary transducers of innate immune system, is critical in microglial functions. Especially, activation of microglia by lipopolysaccharide (LPS), a ligand for …
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Beneficial Effect of the Flavonoid Luteolin on Neuroinflammation
… deficits along with alleviating hippocampal IL-1beta and major histocompatibility complex (MHC) class II mRNA expression in aged mice. Collectively, these studies showed that luteolin might be a promising agent for preventing neuroinflammation and neuronal cell death mediated by activated …
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Maternal Serum and Whey Immune Markers and Eczema Among Infants
<p>Eczema among children and its relation to maternal whey and serum immune markers are considered to either de- or increase risk of the skin disorder. We conducted a prospective study to contrast the role of different maternal immune markers (MIMs) in maternal serum and whey on the development of …
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