Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"IL-1R1"”.
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Identification and characterization of innate immune receptor substrates of γ-secretase enzyme complex
… disease, cancer progression and immune surveillance. It has previously been reported that the Interleukin-1 receptor, type 1, (IL-1R1) is a substrate for regulated intramembrane proteolysis, mediated by presenilin (PS)-dependent γ-secretase activity. The aims of this project were twofold. …
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Macrophage Response to Interleukin-1 Stimulation and the Nature of Cell Surface Interleukin-1 Alpha
Interleukin-1α (IL-1α) is a potent cytokine involved in a range of diseases and can be found expressed on the cell surface (csIL-1α) and in the soluble form, signalling through the type I IL-1 receptor (IL-1R1). IL-1 signalling leads to increased secretion of cytokines, recruitment of immune cells …
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SCI-Induced Chronic Pain is Driven by a Central to Peripheral IL-1 Mediated Signaling Pathway
… Research has also shown that interleukin-1β (IL-1β) is released from the site of SCI within hours of injury, but there is still a significant gap in our knowledge of its role in the development of chronic SCI pain. Recent whole transcriptome RNA sequencing performed by our laboratory has shown …
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Neuromodulation by endogenous Interlukin-1β in hippocampus of the murine brain: Regulation of neuronal excitation
<p>The pro-inflammatory cytokine, Interleukin-1β (IL-1β), is well known for its ability to initiate and propagate inflammatory responses at sites of infection and tissue injury. Paradoxically at odds with this classic view, it is now clear that IL-1β signaling modulates a number of physiological …
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Identifying Key Regulators of the Immune/Inflammatory Response for Developing Anticonvulsive and Antiepileptogenic Approaches
Epilepsy therapy is based on drugs that treat the symptoms, seizures, rather than the disease. There are no treatments for modifying the course of the disease, improving prognosis. Another unmet need is the absence of biomarkers able to identify patients at risk of developing epilepsy or with a …
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Immunological and behavioral consequences of high-fat diet feeding in mice
… that obese mice fed a high-fat diet (HFD), fail to exhibit an interest in saccharin (27% vs 74%) compared to mice fed a low-fat diet (LFD) (p < 0.007). When HFD mice undergo a fasting period of 24 hours, saccharin preferences equilibrate to water consumption (51% saccharin vs 49% water). Other …
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From Flare to Repair: Commensal Bacteria's Influence on Inflammation and Wound Healing
… To that end, Chapter 3 demonstrates that IL-10 deficiency leads to both lung and gut inflammation, which was dependent on commensal bacteria. Two candidate bacteria, Delftia acidovorans and Rhodococcus erythropolis were sufficient to initiate the lung inflammation in the IL-10 deficient …
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Periventricular white matter damage in the post-natal brain in hypoxic conditions
… tumor necrosis factor-a (TNF-a), interleukin-1ß (IL-1ß), monocyte chemoattractant protein-1 (MCP-1), chemokine (C-C motif) receptor 2 (CCR2), and macrophage-colony stimulating factor (M-CSF) expression was observed. Immunoexpression of these was specifically located in AMC from 24h-7d. However, …
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Modulation of bio-behaviors and diabesity by dietary factors
… week by feeding a LFD for 1 week. Interestingly, IL-1R1 -/- mice displayed non-spatial memory deficit regardless of diet, implicating a role for IL-1 in HFD- induced memory deficit. Analysis of the mRNA expression of key cytokines and growth factors in the hippocampus, hypothalamus, and cortex did …
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Extracellular adenosine as a novel neuroimmune modulator
… in adenosine is an increase in brain-based IL-1. Perturbed cognition appears to be a sequela of acute hypoxia but the mechanisms by which cognitive functions are impacted are not clearly defined. In this study, we first examined the impact of acute hypoxia on learning and memory and its …
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MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia
… disease which may lead to death and severe disability [1, 2]. There are two major types of stroke: ischemic and hemorrhagic stroke. Both are associated with disruption of blood flow to a part of the brain with rapid depletion of cellular energy and oxygen, resulting in ionic disturbances and …