Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"IL-1R"”.
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Intestinal Epithelial Cell Intrinsic IL-1R Signaling in Host Defense and Inflammation
Pages viii-xix are misnumbered as pages vi-xvii.
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Interaction Of Afferent Renal Nerve Activity And Il-1R Signaling In Hypertension
… of renal inflammation. Renal interleukin 1-beta (IL-1β) is elevated in many cases of hypertension, as well as the DOCA-salt model of hypertension, and its activity may be responsible for the elevation in afferent renal nerve activity and arterial pressure. IL-1R activation increases the activity …
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Exploring the Role of IL-1β/IL-1R in the Pathogenesis of K-ras Mutant Lung Cancer
… Notably, the pro-inflammatory cytokine IL-1β a potent activator and product of the NF-κB pathway is elevated in the lungs and sera of KM-LUAD patients. We have shown that IL-1β blockade promotes an anti-tumor immune phenotype in a mouse model of KM-LUAD driven by lung epithelial …
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Inflammasome-Independent Interleukin-1 Beta Drives CD4 T Cell Effector Function and Autoimmune Inflammation
… I found that signaling through interleukin (IL)-1 receptor family is required for effector cytokine production by memory CD4 T cells. Mechanistically, IL-1R signaling provides post-transcriptional stability to T cell cytokine transcripts thereby enabling productive secretion of these …
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SKIN COMMENSAL STAPHYLOCOCCUS PROMOTES SYSTEMIC V-GAMMA-6 GAMMA-DELTA T CELL RECONFIGURATION
… skin colonization promotes a robust expansion of IL-17A-producing Vγ6⁺ γδT cells both locally in the dermis and systemically in lymphoid, mucosal, metabolic and central nervous system tissues. This systemic reconfiguration is IL-1R-dependent but independent of IL-23 receptor signaling and the …
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T Cell Intrinsic BCAP Links IL1R to the PI3K-mTOR Pathway and Regulates Pathogenic Th17 Differentiation
Toll-IL-1R homology (TIR) domains are found within adaptor proteins involved in the signaling of Toll like receptors (TLRs) and Interleukin 1 receptor (IL1R) families. Previous work by our lab identified a TIR domain in the protein B cell adaptor for phosphoinositide 3-kinase (BCAP) and determined …
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The Role of Traf6 Phosphorylation In Src/Traf6-Mediated Ikk, Jnk, Akt Activation and Tumorigenesis
… receptor 4 (TLR4), interleukin-1 receptor (IL-1R), and receptor activator of NF-κB (RANK) to their cognate ligands, including lipopolysaccharide (LPS), IL-1, and RANK ligand (RANKL). Recently, TRAF6 has also been shown to be involved in Akt signaling activation upon activation of …
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Investigating the regulation and enzymatic function of human ecsit in innate immune signalling.
… to induce pro-inflammatory cytokines and IFNs. Whilst many of the components of the TLR signal transduction pathways have been identified, a full understanding of these complex regulatory systems remains to be delineated. This thesis probes the molecular, cellular and physiological roles of a …
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Structure and Function of the Pseudokinases IRAK2 and IRAK3 and their Potential as Drug Targets
… receptors (TLRs) and interleukin-1 receptors (IL-1R) are critical components of the innate immune system that recruit the adapter protein MyD88 (myeloid differentiation primary response gene 88), which serves as an assembly platform for members of the interleukin-1 receptor associated kinase …
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Targeting Traf6 For Cancer Therapeutical Development
… Associated Factors (TRAFs) are a family of signal transducer proteins. TRAF6 is a unique member of this family in that it is involved in not only the TNF superfamily, but the toll-like receptor (TLR)/IL-1R (TIR) superfamily. The formation of the complex consisting of Receptor …
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Toll Like Receptor Dependent Control of T Helper 17 Cell Differentiation and Inflammasome Activation
… and differentiation of CD4+ T cells. While IL-12 is critical for Th1 lineage development, IL-6 and TGF-b play an important role in differentiation of Th17 cells in vitro. IL-1 has also been implicated in regulating Th17 differentiation. In this dissertation, we examined the relative …
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Regulation of inflammatory TLR signalling by the BCAP adaptor
BCAP is a PI3K adaptor protein in TLR, BCR and IL-1R and TCR signalling. In TLR signalling, BCAP acts as a negative regulator of inflammatory signalling. Regulation of TLR signalling is essential as overstimulation can cause excessive and pathological inflammation, which leads to serious illnesses …
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Differential proteomic profiling towards elucidation of TB-IRIS pathogenesis
… (CNS)). Immune elements – including neutrophils - involved in the anti-Mycobacterium tuberculosis (Mtb) response are implicated in pathogenesis, which remains incompletely understood. Diagnosis is one of exclusion, no reliable laboratory markers exist, corticosteroid-mediated prophylaxis and …