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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 30 for “"IL-1B"”.

  1. Association of the Interleukin-1 beta and Interleukin-1 Receptor Accessory Protein Gene Polymorphisms with Persistent Hepatitis B Virus Infection and Hepatocellular Carcinoma

    김, 순선2011

    … related to host immune factors. Interleukin-1β (IL-1β) plays significant roles in inflammation and immune defense via IL-1 receptor accessory protein (IL-1RAcP). We investigated whether genetic polymorphisms of IL-1B and IL-1RAcP genes are associated with persistent HBV infection and the presence …

    ajou Repository record

  2. Glucocorticoid receptor signalling and the effect of interleukin 1 beta on glucocorticoid mediated gene expression in intestinal epithelial cell lines Caco-2 and IEC-6

    Toth, Szilvia2012

    … seem to have influence not only on the infiltrated inflammatory cells but also on epithelial cells. It is a clinical observation that about 20 % of IBD patients are resistant to glucocorticoids and requires alternative treatment. Since there are only few data regarding influence of …

    goettingen Repository record

  3. PRG4/CD44/PP2A Signaling Axis: A Significant Regulator of Gout Arthritis

    ElSayed, Sandy

    … and downstream production of interleukin-1b (IL-1b). Xanthine oxidase (XO) catalyzes purines into uric acid (UA) and reactive oxygen species (ROS) that activate NLRP3 inflammasome. Protein phosphatase-2A (PP2A) may be involved in regulating inflammatory pathways in macrophages. …

    chapman Repository record

  4. Positive Emotions and Immune Respose to Influenza in Medically Stable Older Adults

    Gierloff, Maryann J.2016

    … the immune system and may alter susceptibility to infectious diseases, like influenza. The purpose of this investigation was to evaluate the influence of psychological factors, health behaviors, circulating levels of proinflammatory cytokines and the development of influenza-like illness …

    loyola-thes Repository record

  5. Differenzierungsabhängige Modulation der Zytokin- und Chemokinexpression bei humanen myeloischen Zell-Linien

    Schaufler, Jasmin Corinna, Lindemann, Albrecht

    … <br>linienspezifische Zytokin- und Chemokinprofile bestimmt werden. <br>Ebenfalls sollte untersucht werden, ob eine Korrelation zwischen Phänotyp und Zytokin-/Chemokinexpressionsmuster besteht. Bei undifferenzierten und differenzierten Zellen wurde ein intrazellulärer immunzytologischer …

    freiburg-diss Repository record

  6. Phytochemische und pharmakologisch-biologische Untersuchungen von Mikania cordifolia sowie Studien zum molekularen Wirkmechanismus von Sesquiterpenlactonen unter Verwendung des Transkriptionsfaktors NF-AT

    Klaas, Christoph

    … hin untersucht. Aus den oberirdischen Teilen wurden 11 Sesquiterpenlactone vom Germacranolid-Typ und 4 vom Eudesmanolid-Typ isoliert. Die Strukturen der isolierten Verbindungen wurden unter Verwendung NMR-spektroskopischer und massenspektroskopischer Methoden aufgeklärt. <br>Diese …

    freiburg-diss Repository record

  7. Pharmacological profiling of novel melanocortin peptides targeting the hMC1, hMC3 and hMC5 receptors in 2-D and 3-D models of activated chondrocytes

    Can, VediaUniversity of Westminster2024

    … such as Osteoarthritis (OA) affects over 8.75 million people aged 45 and over in the UK alone, resulting in pain, joint stiffness and lack of mobility of the affected joint. The pathology of OA is mediated by a complex inflammatory response predominantly driven by elevated levels of …

    westminster Repository record

  8. Untersuchungen über die Interaktion von Meningokokken mit Zellen der Blut-Hirn-Schranke

    Jaegerhuber, RuthLudwig-Maximilians-Universität

    … Daher wurde in der vorliegenden Studie mit Hilfe eines Zellkulturmodells die Freisetzung von Tumornekrosefaktor alpha (TNF-a), Interleukin-1b (IL-1b), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Monocyten-attrahierendem Protein-1 (MCP-1) und transformierendem Wachstumsfaktor beta (TGF-b) …

    lmu-germany Repository record

  9. Characterizing Zika and West Nile virus infection in mast cells and the antibody-dependent enhancement potential mediated by dengue virus antibodies

    Coish, JeremiaBrock University2025

    … virus (DENV), Zika virus (ZIKV), and West Nile virus (WNV) are evolutionarily related mosquito-borne viruses with antigenic similarities. The antigenic similarities present between 4 circulating DENV serotypes create an immunological paradox called antibody-dependent enhancement (ADE) …

    brock Repository record

  10. Basi molecolari della differente risposta delle cellule alpha e beta del pancreas di mammifero all apoptosi mediata da citochine: implicazioni patogenetiche nel Diabete Mellito

    CONDORELLI, ANGELO GIUSEPPEUniversità degli studi di Catania2014

    … forma autoimmune della patologia, l'apoptosi è il risultato di una complessa cascata di eventi che inizia con l esposizione delle beta cellule pancreatiche a molecole citotossiche espresse o secrete dalle cellule del sistema immunitario ed infiltranti l isola del Langerhans nel corso dell …

    catania Repository record

  11. Targeted Delivery of Surface Modified Nanoparticles: Modulation of Inflammation for Acute Lung Injury

    Desu, Hari R.2016

    … is no FDA approved pharmacological treatment available except the supportive mechanical ventilation therapy. Numerous clinical trials involving pharmacological therapies aimed at different pathological targets turned unsuccessful. National Institute of Heart Lung and Blood Institute (NHLBI) cited …

    tenn-hsc Repository record

  12. Brain Inflammation Regulated by PINK1

    김, 준2012

    … PINK1 is a well-known autosomal recessive familial PD gene, expressed in both neurons and glia. In this study, I analyzed the roles of PINK1 in brain inflammation using slice cultures prepared from PINK1 knockout (KO) and wild type (WT) mice since slicing mimics injury. For up to 24 h after …

    ajou Repository record

  13. EVALUATION OF ALPHA-D-GLUCAN NANOPARTICLE AS A VACCINE ADJUVANT

    Lu, Fangjia

    … cells and their biological properties can be tailored to the desired function. Here, we evaluated the potential of dendrimer-like α-D-glucan nanoparticles, derived from a variety of sweet corn, as a vaccine adjuvant. The nanoparticles, termed Nano-11, have an average diameter of 75-80 nm and …

    purdue-thes Repository record

  14. Expresión y significación clínica de las citoquinas en el cáncer de mama

    Miranda Peláez, María Ángeles2014

    … se ha investigado la expresión de las citoquinas IL-1, IL-5, IL-6, IL-17, IFN-ß y NFkB en carcinomas ductales invasivos de mama de 108 pacientes por un método inmunohistoquímico, analizando su expresión por las células tumorales, los fibroblastos y las células mononucleares inflamatorias (CMIs) …

    oviedo Repository record

  15. Untersuchungen zur Yersinia enterocolitica-stimulierten Genexpression in Epithelzellen

    Kampik, DanielLudwig-Maximilians-Universität

    … wichtige Rolle als Vermittler zwischen äußerem Milieu und darunterliegender Mukosa. Epithelzellen treten als Erste mit potentiellen Pathogenen in Kontakt: durch die Sekretion von Zytokinen als Warnsignale an umliegende Zellen können sie eine Entzündungsreaktion einleiten. Yersinia enterocolitica …

    lmu-germany Repository record

  16. Polarised secretion of leukaemia inhibitory factor

    Hill, Eric J.Aston University2004

    … LIF secretion has yet to be described and could illuminate the mechanisms of LIF localisation. Here the polarised endogenous secretion of human LIF and IL-6 in Caco-2 cells was characterised under normal culture conditions and following induction with IL-1b. Whether the apical or basolateral …

    aston Repository record

  17. Expression and function of the NLRP3 inflammasome in Behçet’s disease

    김, 은형2016

    … 및 mRNA 의 발현을 말초혈액단핵구에서 확인하고 또한 LPS 와 ATP 자극에 따른 IL-1β 의 발현 양상을 알아보고자 했다. 재료 및 방법:활동성 베체트병 환자 (15명), 비활동성 베체트병 환자 (15명), 정상 대조군 (15명)을 대상으로 하였다. 베체트병 환자는 질명의 활성도에 따라 활동성와 비활동성으로 구분하였다. 모집된 각 그룹으로부터 얻은 혈액에서 분리된 말초혈액단핵구를 자극 및 배양하였고, 실험 대상 혈액에서의 mRNA 발현의 정량화를 위해 real time PCR을 시행하였고 단막질의 발현은 웨스턴 블롯팅 …

    ajou Repository record

  18. Modeling host responses to tick feeding and tick-borne flavivirus evolution and dispersal

    Heinze, DarThe University of Texas Medical Branch at Galveston2017

    … animals for an extended period of time. To facilitate feeding, ticks secrete a complex mixture of salivary molecules that inhibit host responses such as coagulation, complement, itch responses, and immune responses. Ticks act as vectors for an extremely broad range of human and animal …

    utmb Repository record

  19. Characterization of NADPH Oxidases in Uterine Smooth Muscle during Pregnancy

    Waller, Mikayla Dawn WardUniversity of Saskatchewan2020

    … transforms from a quiescent tissue to a contractile muscle required for parturition. Immune system activation is a crucial precursor to labour during which the myometrium is infiltrated by immune cells. Immune and myocyte activation rely on signal transduction via oxidation-reduction reactions …

    sask Repository record

  20. A comparison of gene expression in tolerated and rejected islet grafts by gene microarray analysis

    Berg, Tobias

    … and good graft function mononuclear cell infiltration surrounding the islet was found in tolerated grafts. To elucidate the differences between these mononuclear infiltrates in the presence of tolerance and destructive mononuclear infiltrates during graft rejection as well as their influence …

    freiburg-diss Repository record

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