Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 72 for “"IL-18"”.
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Significant Association of IL-18 Genetic Polymorphisms with Aspirin-Intolerant Urticaria in a Korean Population
… understood, mast cell activation and neutrophil infiltration have been suggested to be involved. Interleukin-18 (IL-18) can stimulate mast cells and then release inflammatory mediators such as IL-4, IL-13 by stimulating mast cells. IL-18 activates neutrophils by inducing the production of …
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THE INNATE CYTOKINE IL-18 INHIBITS CNS AUTOIMMUNITY THROUGH PREFERENTIAL ACTIVATION OF PROTECTIVE CD8 T-CELLS
… is widely thought to challenge self-tolerance. IL-18 is an innate, inflammasome-activated cytokine and potent amplifier of T-cell activation. In excess, IL-18 is associated with certain autoinflammatory, but not autoimmune, diseases. We tested how excess IL-18 affected susceptibility to …
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Fibrosarcoma-induced Dysregulation of Interleukin (IL)-1β and IL-18 Activities and their Modulation by Paclitaxel
Cancer remains an elusive killer due, in part, to the suppression of normal immunologic antitumor responses. Normal host (NH) macrophage (Mϕ) populations have tumoricidal effects such as tumor antigen phagocytosis and presentation, and cytokine production. Tumor-infiltrating Mϕs may evade these …
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Targeting of IL-1 and IL-18 in experimental arthritis using soluble receptors - A gene thereapeutic approach.
Contains fulltext : 19574.pdf (Publisher’s version ) (Open Access)
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The Role of Interferon Gamma in the Regulation of IL-18 Binding Protein and the Development of Autoimmune Arthritis in a Genetically Non-Susceptible Mouse Strain
… removed by genetic deletion, however, susceptibility to CIA is conferred. In addition, T cell responses against the immunogen that stimulates CIA, type II collagen (CII), are reduced in the B6 strain when compared to susceptible mouse strains that express differing MHC haplotypes such as the …
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Einfluss von Interleukin-18 auf das Th1/Th2-Zytokingleichgewicht mononukleärer Nabelschnurblutzellen in vitro
IL-18 wurde erstmals 1989 beschrieben und lange Zeit als "IFN-Gamma inducing factor" bezeichnet, welcher die Ausbildung einer Th1-Immunantwort stimuliert. In den letzten Jahren konnte für IL-18 zudem die Induktion Th2-spezifischer Zytokine aufgezeigt werden. Bei Atopikern, welche durch das …
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Análise de receptores tool-like e citocinas envolvidas na susceptibilidade à infecções virais
… devido a presença de sintomas altamente debilitantes como, inflamações nas articulações que podem durar meses ou anos. A inflamação induzida pela infecção viral está associada a moléculas da imunidade inata, mas pouco se sabe sobre os mecanismos envolvidos na patogênese da infecção, não …
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Exploring the Role of the Inflammasome Pathway in Diabetic Retinopathy
… in DR post-surgery. The role of interleukin (IL)-18, an inflammasome activation biomarker, in DR pathogenesis was further examined using a novel human organotypic retinal culture (HORC) model, where donor retinal explants were cultured in IL-18 without and with high glucose. Results: The NLRP3 …
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Klonierung und Charakterisierung des Zytokins Interleukin-18 sowie der Zelloberflächenproteine CD3 epsilon, CD4, CD8 alpha und MHCII beta der Ente : Generierung von Werkzeugen für immunologische Studien im Enten-Hepatitits-B-Virus-Modell
… behindert. <br>Das Zytokin IL-18 kann je nach der An- oder Abwesenheit anderer Zytokine eine Immunreaktion des Typs Th1- aber auch des Typs Th2 hervorrufen. Im HBV-transgenen Mausmodell inhibiert IL-18 die hepadnavirale Replikation in der Leber. <br>Daher sollte das IL-18 der …
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Inflammatory markers as novel predictors of cardiovascular disease
… protein (CRP) and, more recently, interleukin- (IL-) 6. This thesis reviews the literature and suggests the need for further research into novel inflammatory markers of CVD risk. The broad aim was to expand on limited existing data and ascertain if circulating levels of four novel inflammatory …
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Streptavidin-cytokine fusion proteins for use as adjuvants in cancer vaccines
… an unspecific immune response. The cytokines IL-2 and IL-18 both promote TH1-type responses; IL-2 is already in clinical use as a cancer therapy, while investigation of the role of IL-18 as an immunotherapy is ongoing.A strategy was devised for the production of novel recombinant fusion …
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Regulation of T cell effector functions in the intestinal mucosa
… antigen in the context of major histocompatibility complex (MHC) molecules on antigen presenting cells (APCs). The effector functions of CD8+ T cells includes the MHC-I dependent recognition and lysis of target cells (e.g. virally infected cells) through the release of degranulating cytotoxic …
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Transcriptional Regulation of NLRC4 Inflammasome by IRF8
… of the inflammasome-dependent cytokines IL-1β and IL-18 and cell death were impaired in IRF8-deficient cells. IRF8 mediated the transcription of genes encoding NAIPs, the receptors for NLRC4 inflammasome, which recognize bacterial flagellin and type III secretion system (T3SS) proteins. …
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Tumor-Bearing Host Macrophage Dysfunction: Role of CD40/CD40L Interactions
… is caused, in part, by the loss of immune surveillance leading to the inability of the immune system to destroy the cancer cells. Macrophages (Mfs) are essential cellular components of the immune system; they influence immune responses in diverse and fundamental ways. As a consequence, Mfs …
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IL-1R8: A Novel Checkpoint Regulating Anti-Tumor And Anti-Viral Activity Of NK Cells
IL-1R8 is an Interleukin-1 receptor family member that acts as a negative regulator of IL-1 family receptor and Toll-like receptor (TLR) signaling. Both murine and human NK cells express high levels of IL-1R8 but its functional role in this cell type has not been described so far. Natural Killer …
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L'impatto degli antipsicotici long-acting sui marker della neuroinfiammazione associati alla schizofrenia
… generazione di citochine pro-infiammatorie, come IL-1β e IL-18. Questo studio si propone di esaminare la relazione tra i livelli ematici di cito-chemochine, come IL-1β, IL-18, TGF-β1, RANTES, Eotaxina, e la somministrazione di terapia con antipsicotici iniettivi di prima e seconda generazione a …
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Modulation of macrophage and epithelial cell immune defences by probiotic bacteria: immune stimulation versus suppression
… cytokine suppression, and augmentation of IL-10 production in the gut relate to endotoxin tolerance. Endotoxin tolerance is a context; it could present an example for cell drive through a hypo-responsive state. An example is mu-cosal inflammatory pathologies, such as Crohn’s disease. When …
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Differential regulation and functions of the ZFP36-family RNA binding proteins in CD8⁺ memory T cells
… by the TCR, pro-inflammatory cytokines such as IL-12 and IL-18 can induce antigen-independent bystander activation of memory T cells. The ZFP36-family of RNA binding proteins, including ZFP36 and ZFP36L1, contribute to the regulation of mRNA stability, protein translation and therein, T cell …
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Rodent inflammasome activation by Toxoplasma gondii
… chronic infection relies on the parasite's ability to find a balance between activation of a host immune response and evasion of parasiticidal mechanisms. This balance is achieved through the modulation of host cell processes by parasite proteins secreted from specialized secretory organelles …
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TLR4 endogenous ligand S100A8/A9 levels in adult-onset Still’s disease and their association with disease activity and clinical manifestations
… disease activity in patients with systemic juvenile idiopathic arthritis or adult-onset Still’s disease (AOSD). We investigated the clinical significance and the pathogenic role of this marker in AOSD. Materials and Methods: Serum samples were collected from 36 AOSD patients, 40 rheumatoid …
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