Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 117 for “"IL-17"”.
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Role of Il-17/Il-17Ra Signaling In The Pancreatic Tumor Microenvironment
… Our research has revealed the important role of IL-17 in the development and progression of pancreatic cancer, yet the specific cellular compartment responsible for IL-17-mediated tumor promotion remains unknown. We generated a transgenic mouse model with pancreatic KrasG12D activation and …
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Molecular Basis of Upregulation of IL-17 in Estrogen Model of Inflammation
Interleukin-17 (IL-17) plays a major role in inflammation by regulating the induction of various proinflammatory genes, which aid in the recruitment and activation of neutrophils. Although IL-17 is considered to be protective in infection, overproduction of IL-17 in conditions like autoimmune …
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Preclinical evaluation of a vaccine against IL-17 mediated inflammatory diseases including psoriasis
… a chronic autoimmune skin condition. Interleukin 17A (IL-17A) is a pro-inflammatory cytokine with a key role in the pathogenesis of this disease. Antibodies targeting IL-17A have shown superior efficacy compared with other psoriasis treatments, and long-term studies have demonstrated these to be …
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The Role of the IL-23/Th17/IL-17 Axis in the Pathophysiology of Endometriosis
… as dyspareunia, dysmenorrhea, and infertility. Due to invasive diagnosis, disease heterogeneity, and reproductive disorder stigmatization, patients often experience misdiagnosis and significant diagnostic delays. No reliable, non-invasive, non-hormonal therapeutic options exist, …
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The development of a liposomal form Secukinumab – an IL 17 pathway inhibitor in the treatment of psoriasis
… effects, is Secukinumab. Secukinumab is an anti-IL17 antibody that works by stopping the action of IL17, a cytokine that is known to have a major role in the pathogenesis of psoriasis. This work is based on the development of a new way to commence drug therapy to reduce the side effects of the …
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The development of a liposomal form Secukinumab – an IL 17 pathway inhibitor in the treatment of psoriasis
… effects, is Secukinumab. Secukinumab is an anti-IL17 antibody that works by stopping the action of IL17, a cytokine that is known to have a major role in the pathogenesis of psoriasis. This work is based on the development of a new way to commence drug therapy to reduce the side effects of the …
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AIRWAY SURFACE HYPERVISCOSITY AND DEFECTIVE MUCOCILIARY TRANSPORT BY IL-17/TNF-ALPHA ARE CORRECTED BY BETA-ADRENERGIC STIMULUS
… and inflammation. We investigated the effects of IL-17A plus TNF-α, 2 cytokines with relevant roles in CF and other chronic lung diseases. Transcriptome analysis revealed a profound change with upregulation of several genes involved in ion transport, antibacterial defense, and neutrophil …
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The stimulatory role of ICOS in the development of CD146+CCR5+ T cells co-expressing IFN-γ and IL-17 during graft-versus-host disease
… as CD146+CCR5+ T cells, co-expressing IL-17A and IFN-γ. We found that the inducible T-cell costimulator (ICOS), which has been reported to be important for human Th17 differentiation in vitro, is critical for the development of this nonconventional T Helper 1 (Th1*)-polarized …
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Alterations in endometrial immune cell populations affect endometrial cell functions
Endometriosis is a debilitating disease that is diagnosed in 0.5-5% fertile and 25-40% of infertile women, but the underlying mechanisms involved in progression of the disease as well as the associated infertility are yet unclear. Research now shows evidence that the immune system has a pivotal …
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Elucidating Mechanisms Involved In Host Microbial-Tumor Interactions
… (TME) which limits efficacy of most available therapies. The tumoral niche provides a privileged microenvironment for microbial colonization that can in turn mediate local effects on the cells in the TME. We previously reported that long-term survival in PDAC is associated with an …
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Neurochemical drivers of visceral pain: insights into the roles of interleukin-17 and the proton-sensing G protein-coupled receptor GPR68
… pain in the gut, with a focus on interleukin 17 (IL-17) and the proton-sensing G protein-coupled receptor (GPCR) GPR68. In the first part of my research, I identified IL-17 as a pro-nociceptive cytokine. This was based on transcriptomic data showing elevated IL17A expression in colonic …
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MicroRNA as Regulator of the Th17 Inflammation in Behcet's disease
… and 19 healthy controls (HC). To verify Th17 inflammation in BD patients, IL-17 expression was measured using flow cytometry, enzyme-linked immunosorbent assay (ELISA), and real-time polymerase chain reaction (PCR) in peripheral blood mononuclear cells (PBMCs) with or without Th17 …
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Role of Notch Signaling in T Cell Polarization
… effector subsets recently discovered is Thelper 17 (Th17) and it plays a predominant role in autoimmune diseases and inflammatory disorders.</p><p>In my thesis, I aimed to study the role of Notch cell surface receptors in Th17 differentiation. Using in vitro Th17 differentiation assays of human …
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Innate Interleukin-17 and Interleukin-22 play important roles in viral hepatitis
Intrahepatic cell-derived IL-17 and IL-22 are important for T cell priming and hepatoprotection in viral hepatitis, respectively; however, the source and regulation of these cytokines in the liver microenvironment are not well defined. Here, we present evidence for a significant expansion of IL-17- …
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Major traumatic injury : serum cytokine biomarkers as predictors of poor clinical outcome
… morbidity worldwide, accounting for about 5.8 million deaths annually. England alone sees approximately 25,000 cases of major trauma each year and over a fourth of these result in loss of life. Death due to trauma is time factorial and bimodally distributed. The first phase appears within an …
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FUNCTIONAL CHARACTERIZATION OF THE INTERACTION BETWEENP. AERUGINOSA AND DENDRITIC CELLS TRIGGERING THE DIFFERENTIATION OF PATHOGENIC TH1/17 CELLS IN CYSTIC FIBROSIS.
… (Pa). Nonostante l’ambiente polmonare ostile generato dalla disfunzione del CFTR, Pa è in grado promuovere una costante attivazione del sistema immunitario innato e adattativo. Infatti, oltre al ruolo pro-infiammatorio dannoso di neutrofili e macrofagi, i linfociti Th1/17 co-produttori di …
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Expression of Th17 and related cytokines according to clinical activity of Behcet's disease
… of other T cell populations were discovered, and IL(Interleukin)-17 producing Th17 cells were recognized as novel group of T cells which play a major role in autoimmunity. A recent study has shown elevated production of IL-17, IL-23, and IFN (Interferon)-γ by peripheral blood mononuclear cells …
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Investigation Into The Molecular Mechanisms Underlying Idiopathic Intracranial Hypertension
… (C-C motif) ligand 2 (CCL2), interleukin (IL)-17 (IL-17), IL-6, IL-1β, tumour necrosis factor-α (TNF-α), as well as adipocyte-derived hormone leptin and the glucocorticoid hydrocortisone (HC). <br></br><br></br> Female Wistar rats raised on a HF diet were shown to have the highest CSF …
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