Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"IL-15Rα"”.
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Anti-inflammatory Role of IL-15Rα Up-regulated by Poly I:C in Herpes Simplex Virus-induced Behcet's Disease-like Mouse Model
… system affects. Interleukin-15 receptor alpha (IL-15Rα) forms stable complex with IL-15 on the cell surface of activated monocytes and mediates the proliferation of memory CD8+ T cells. Recent studies informed that Polyinosinic:polycytidylic acid (Poly I:C) is an immunostimulant which boosts the …
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Determining The Mechanisms Generating Soluble Il-15 Complexes
… agonists enhance the expression of Interleukin (IL)-15. Additionally, inducing lymphopenia enhances anti-tumor responses in an IL-15-dependent manner. Paradoxically, despite the limited expression of IL-15 during homeostasis, the role of IL-15 during the steady state is well-known, while its …
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Effect of platinum chemotherapy on tumour infiltrating immune cells in metastatic ovarian cancer: Mechanistic insights and therapeutic applications
… remains unclear to what extent innate Natural Killer (NK) cells contribute. Using two syngeneic models (UPK10 and ID8p53<sup>-/-</sup>) of metastatic ovarian cancer this thesis found that treatment with carboplatin upregulates NK cell activating receptor ligands, induced a pro-inflammatory …
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Immunostimulatory activity and antitumor efficacy of mSOT201 immunocytokine
… mSOT201 immunocytokine consisting of an IL-15 mutein linked through short flexible oligopeptide linker to IL-15Rα sushi+ domain and fused to the C-terminus of anti-mouse PD-1 mAb, thereby directing the cytokine payload to PD- 1⁺ tumor infiltrating lymphocytes. We aimed to determine …
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A Novel Interleukin-15 Receptor Antagonist for the Treatment of Rheumatoid Arthritis
… arthritis (RA) affects approximately 1.3 million adults in the United States, causing debilitating joint inflammation, pain, and potential disability. Current treatment options, including methotrexate and biologics like adalimumab, have limited efficacy, leaving a substantial number of …
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Redirecting T Cells With Chimeric Antigen Receptors to Target Cd123+ Leukemia
… Ph.D</p> <p>CD123 or interleukin receptor alpha (IL-3Rα) is expressed on hematological malignancies such as acute myeloid leukemia (AML) and some acute lymphoblastic leukemia (ALL). Significantly, CD123 is over-expressed on leukemic stem cells (LSCs) compared to normal hematopoietic stem cells and …
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Role of cytokine IL-15 in the homeostasis of the intestinal epithelium and inflammatory bowel diseases
… are characterized by increased intestinal permeability caused by intestinal mucosal barrier dysfunction, a critical factor in the pathogenesis of IBD. The immune system is the major effector of this tissue damage, through the action of multiple cell types as well as soluble mediators, such as …