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Showing 1 to 20 of 55 for “"IL-15"”.
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Determining The Mechanisms Generating Soluble Il-15 Complexes
… agonists enhance the expression of Interleukin (IL)-15. Additionally, inducing lymphopenia enhances anti-tumor responses in an IL-15-dependent manner. Paradoxically, despite the limited expression of IL-15 during homeostasis, the role of IL-15 during the steady state is well-known, while its …
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Elucidating The Roles of Il-15 In The Tumor Microenvironment
<p>ELUCIDATING THE ROLES OF IL-15 IN THE TUMOR MICROENVIRONMENT</p> <p>Rosa M. Santana Carrero, B.S.</p> <p>Advisory Professors: Shao-Cong Sun, Ph.D. & Kimberly S. Schluns, Ph.D.</p> <p>Interleukin-15 (IL-15) is a factor that promotes activation, proliferation, cytotoxicity, and survival of CD8 T …
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Quantitative analysis of IL-2 and IL-15 signal transduction in T lymphocytes
IL-2 and IL-15 are common y-chain family cytokines critically involved in regulation of T cell differentiation and homeostasis. Both cytokines signal through a heterotrimeric surface receptor complex (IL-2/15R) composed of an [alpha], a [beta], and the common gamma ([gamma]c) chain. Signaling …
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Investigating IL-15 Metabolic Impact and Its Mechanism of Action in Skeletal Muscle Cells
… changes throughout the whole body to facilitate adaptation to physical exercise. Interleukin-15 (IL-15) is highly expressed in skeletal muscle and appears to influence many metabolic parameters that are defective in metabolic pathologies such as insulin resistance. For instance, IL-15 …
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Role of cytokine IL-15 in the homeostasis of the intestinal epithelium and inflammatory bowel diseases
… are characterized by increased intestinal permeability caused by intestinal mucosal barrier dysfunction, a critical factor in the pathogenesis of IBD. The immune system is the major effector of this tissue damage, through the action of multiple cell types as well as soluble mediators, such as …
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Determining The Roles of Dendritic Cells and Icam-1 In The Transpresentation of Il-15 to Cd8 T Cells
… memory CD8 T cells is dependent on the cytokine IL-15. IL-15 is delivered by a novel mechanism termed transpresentation: IL-15 is presented by a cell expressing IL-15Ralpha to the CD8 T cell which responds via IL-2Rbeta/gamma<sub>c</sub>. The identity of what cells transpresent IL-15 to support …
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Determining The Roles of Dendritic Cells and Icam-1 In The Transpresentation of Il-15 to Cd8 T Cells
… memory CD8 T cells is dependent on the cytokine IL-15. IL-15 is delivered by a novel mechanism termed transpresentation: IL-15 is presented by a cell expressing IL-15Ralpha to the CD8 T cell which responds via IL-2Rbeta/gamma<sub>c</sub>. The identity of what cells transpresent IL-15 to support …
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Tethered Il-15 to Augment The Therapeutic Potential of T Cells Expressing Chimeric Antigen Receptor: Maintaining Memory Potential, Persistence, and Antitumor Activity
<p><strong>Tethered IL-15 to augment the therapeutic potential of T cells expressing chimeric antigen receptor: Maintaining memory potential, persistence, and antitumor activity</strong></p> <p>Adoptive immunotherapy can retarget T cells to CD19, a tumor-associated antigen (TAA) expressed on B-cell …
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Defining The Role of Il-15 Trans-Presentation By Distinct Cell-Types During The Development and Homeostasis of Natural Killer and Invariant Natural Killer T Cells
… of NK and iNKT cells is extremely important. IL-15 has been shown to provide a critical signal throughout the development and homeostasis of NK and iNKT cells; however, the cellular source of IL-15 has remained unclear. In this investigation, I provide evidence that the cell-type providing …
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Interleukin-2 Engineering for improved therapeutic effectiveness
… for its private alpha receptor subunit, unlike wild-type IL-2 (K[d] [approximately] 10 nM). IL-2 mutants with picomolar affinity for IL-2Rα stimulate T cell growth responses quantitatively equivalent to those mediated by IL-15. Our results suggest that the contrasting effects of IL-2 and IL-15 on …
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Investigating the movement of intestinal intraepithelial lymphocytes using an organoid co-culture system
… along the epithelium to the immunosurveillance of the guts. However, little is known about how these immune cells move.<br/><br/>Intestinal organoids are three-dimensional structures of epithelial cells that mimic the gut epithelium in vitro. In this study a murine IEL-organoid …
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Characterization and Optimization of Antigen-Specific T Cell Responses During Ex Vivo Expansion of Melanoma Tumor-Infiltrating Lymphocytes
… involves an initial phase (pre-REP) of tumor-infiltrating lymphocyte (TIL) expansion ex vivo from tumor isolates followed by a second phase, “rapid expansion protocol” (REP) generating the billions of cells used as the TIL infusion product. The main question addressed in this thesis was how the …
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Treatment of murine tumors with recombinant Myxoma viruses
… that expresses the murine gene for interleukin 15 (IL-15) was also used, in order to determine if increased expression of IL-15 within the tumor bed could improve MYXV treatment by recruiting additional anti-tumor immune cells to the tumor. In vitro experiments evaluated MYXV infectivity in …
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Der Einfluss von HLA-G und HLA-E auf Large Granular Lymphocytes
… der Sekretion der Zytokine TNF-a, IFN-g, GM-CSF, IL-5, IL-10, IL-13 und IL-15 gemessen. Dabei zeigte die Chorionkarzinomzelllinie JEG-3 eine Unterdrückung der TNF-a-, IFN-g-, GM-CSF- und IL-13-Produktion, aber eine Erhöhung der IL-10- und IL-15-Produktion gegenüber JAR. Möglicherweise tragen aber …
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Antigen-specific memory T cell distribution in non-lymphoid tissue
… Knock-out studies in mice show that interleukin 15 (IL-15) is essential for memory CD8+ T cell proliferation. Fibroblasts, macrophages, dendritic cells and epithelial cells express IL-15 and its receptor isoform [alpha] (IL-15R[alpha]). Histological studies suggest that memory CD8+ T cells …
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Interleukin-15 and [alpha](1,3)galactosyl-expressing vaccine combination therapy for melanoma
… the B16alphaGal vaccine, in the present study, IL-15-expressing vaccine cells (B16IL-15) were administered to mice in combination with the B16aGal vaccine with or without B16N/V vaccine cells (irradiated B16F0 melanoma cells). As documented in literature, IL-15 stimulates the proliferation and …
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Progesterone control of human endometrial cells
… stroma. However, mediators with the ability to activate the protein kinase A/cAMP pathway, such as Prostaglandin E₂ (PGE₂) and relaxin, are potent inducers of decidualisation when administered alongside progesterone in endometrial stromal cells (ESCs) in vitro. Uterine Natural Killer …
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Cytokine priming enables triggering of naive auto-reactive CD8[superscript +]T cells by weak agonist ligands of the TCR
… peptide presented on class-I major histocompability complex (MHC-I) molecules. The second signal is delivered via the co-stimulatory receptors upon recognition of their ligands on antigen presenting cells. However, in response to homeostatic pressure, as in lymphopenia, naive T cells undergo …
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