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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 120 for “"IL-13"”.

  1. Die Rolle von IL-4 und IL-13 in Maus-Modellen für allergische Erkrankungen

    Hahn, ChristianUniversität Würzburg

    IL-4 und IL-13 sind wichtige Faktoren bei der Entwicklung allergischer Erkrankungen. In dieser Arbeit wird die Rolle von IL-4 und IL-13 in einem Maus-Modell für allergisches Asthma während der allergischen Sensibilisierung und in einer etablierten asthmatischen Erkrankung untersucht. Weiterhin wird …

    wurz-thes Repository record

  2. Investigating the role of IL-4/IL-13 and their receptors in ulcerative colitis

    Hoving, J ClaireDepartment of Clinical Laboratory Sciences2010

    … limited to the distal colon and mixed neutrophil/lymphocyte infiltration in the superficial layer of the mucosa. The Th2 cytokines interleukin (IL)-4 and IL-13 are associated with the onset of oxazolone colitis and both signal through a common IL-4 receptor-alpha chain (IL-4R +-). Neutralizing …

    cape-town Repository record

  3. The role of IL-4 and IL-13 responsiveness during Schistosoma mansoni induced inflammation

    Marillier, Reece GerradDivision of Immunology2008

    … the host’s survival. Where as T cell-specific IL-4Rα has been shown not to be essential for survival, macrophage/neutrophil-specific IL-4 receptor α-deficient mice (LysMIcre L-4Rα-/lox ), mice lacking alternative macrophages (AAMФ), had severe intestine pathology and high endotoxin levels due …

    cape-town Repository record

  4. IL-4/IL-13-inducible lincRNA-MIR99AHG regulates macrophage polarization and promotes intracellular survival of Mycobacterium tuberculosis

    Gcanga, LonaDepartment of Clinical Laboratory Sciences2020

    … (TB) caused by Mycobacterium tuberculosis (Mtb) kills 1.6 million people worldwide every year, and there is an urgent need for targeting host-pathogen interactions as a strategy to reduce mycobacterial resistance to current antimicrobials. Non-coding RNAs are emerging as important regulators of …

    cape-town Repository record

  5. Investigating the role of CD28 costimulation and IL-4/IL-13 responsive myeloid and lymphoid cells during helminth infections in mice

    Ndlovu, H HlumaniDepartment of Clinical Laboratory Sciences2013

    … primary and secondary infections with N. brasiliensis. Our findings demonstrate that CD28 is required for initiation of protective Th2 immunity against primary infection with N. brasiliensis. Furthermore, the absence of CD28 impairs development of memory CD4⁺ T cell responses resulting in …

    cape-town Repository record

  6. Immune and allergic responses to Anisakis pegreffii, with focus on the roles of IL-4, IL-13 and the IL-4 receptor alpha

    Nieuwenhuizen, NatalieDivision of Immunology2007

    … and allergic responses to A. pegreffii in wildtype and gene deficient mice, with special focus on interleukin(IL)-4, IL-13, and the IL-4 receptor alpha (IL-4Rα). Experimental murine models of Anisakis infection, Anisakis-induced anaphylaxis and Anisakis-induced dermatitis were established in …

    cape-town Repository record

  7. The role of IL-4 and IL-13 in pulmonary tuberculosis using gene-deficient mice and protective efficacy of the purine-deficient auxotroph of Mycobacterium tuberculosis

    Brown, NajmeeyahDivision of Immunology2002

    Absence of the TH2 inducing cytokine IL-4 has been shown not to increase the TH1 response and resistance to mycobacterial infection. This study asked whether the combined absence of IL-4 and IL3, as compared to IL-4 deficiency only, would increase resistance to an aerogenic Mycobacterium …

    cape-town Repository record

  8. Investigating the role of IL-4/IL-13 signalling through the IL-4 receptor alpha (IL-4Rα) on keratinocytes in murine models of Leishmania major and Schistosoma mansoni

    Govender, MelissaDivision of Immunology2017

    … is important during the parasite life cycle. While Th1 immunity is required to control CL, protection during schistosomiasis requires Th2 immunity. Paradoxically, Th2 characteristic IL-4 secreted early during L. major infection in mice, can drive a Th1 response by instructing dendritic cells to …

    cape-town Repository record

  9. TL1A Priming Induces a Multi-Cytokine Th9 Cell Phenotype That Promotes Robust Allergic Inflammation in Murine Models of Asthma

    Niese, Michelle Liu2024

    The TNF superfamily member TL1A is a costimulatory molecule that signals through its receptor DR3 on T lymphocytes. The Th9 subset of T lymphocytes secretes the pleiotropic cytokine IL-9 which has functions in allergic airway disease, helminth infections, and tumor immunity. TL1A increases IL-9 …

    iupui Repository record

  10. Charakterisierung der allergischen Immunantwort : Vergleich der in-vitro Zytokinproduktion isolierter mononukleärer Zellen und der in-vitro Zytokinproduktion aus Vollblutproben bei Neonaten und Erwachsenen

    Silberer, Jutta Bianca

    … wurden die Konzentrationen der Zytokine IFN-g, IL-10 und IL-13 mittels ELISA quantifiziert. <br>Bei den Neonaten wurden sowohl nach PHA -, als auch BLG-Stimulation signifikant niedrigere IFN-g (MC: PHA 588 pg/ml; BLG 819 pg/ml) - und IL-10-Werte (MC: PHA 485,7 pg/ml; BLG 163,4 pg/ml) gefunden, …

    freiburg-diss Repository record

  11. Transcriptomic phenotyping of the macrophage response to filarial nematode infection

    Thomas, Graham DavidThe University of Edinburgh2013

    … are characterized, amongst other things, by IL-4 and IL-13 production from CD4* Th2 cells. IL-4 and IL-13 induce alternatively activated macrophages (AAMΦ) via their action on the IL-4Rα receptor subunit. AAMΦ are also implicated in numerous other diseases such as fibrosis, allergy, cancer …

    edinburgh Repository record

  12. Longitudinal relationships between family routines and biological profiles in youth with asthma

    Schreier, Hannah Milena CarolineUniversity of British Columbia2008

    While numerous studies have linked family routines to pediatric asthma outcomes, it remains unclear how family routines come to be associated with these outcomes on a biological level. The current study investigated whether longitudinal trajectories of inflammatory markers of asthma could be …

    ubc Repository record

  13. Major traumatic injury : serum cytokine biomarkers as predictors of poor clinical outcome

    Ramaswamy, DS2021

    … morbidity worldwide, accounting for about 5.8 million deaths annually. England alone sees approximately 25,000 cases of major trauma each year and over a fourth of these result in loss of life. Death due to trauma is time factorial and bimodally distributed. The first phase appears within an …

    salford Repository record

  14. Targeting pro-inflammatory mediators to treat visceral pain

    Barker, KatieUniversity of Cambridge2022

    … of cultured DRG neurons, I first examined the ability of several mast cell mediators to activate sensory neurons. I observed that mast-cell derived cytokines (TNFα & IL-4), lipids (PGD2 & LTC4) and growth factors (NGF & SCF) all increased [Ca2+]i in distinct populations of DRG neurons, the …

    cambridge Repository record

  15. The role and host-directed targeting of long non-coding RNAs in macrophage polarization during Mycobacterium tuberculosis infection

    Pillay, ShandréDepartment of Clinical Laboratory Sciences2022

    … World Health Organization (WHO) reported 1.5 million tuberculosis (TB)- associated deaths and an incidence of 10 million new cases. The causative, Mycobacterium tuberculosis (Mtb), evades host immune responses by skewing macrophage polarization towards a less microbicidal alternative state to …

    cape-town Repository record

  16. Maternal Serum and Whey Immune Markers and Eczema Among Infants

    Boyd, Keith Levi

    <p>Eczema among children and its relation to maternal whey and serum immune markers are considered to either de- or increase risk of the skin disorder. We conducted a prospective study to contrast the role of different maternal immune markers (MIMs) in maternal serum and whey on the development of …

    south-carolina Repository record

  17. Studies on the Mechanism of Polyamine-and Prothrombin kringle-2-induced Degeneration of Neuron and Microglia

    원, 소윤2011

    … ligand for transient receptor potential vanilloid 1 (TRPV1), could mediate 6-hydroxydopamine (6-OHDA)-induced Mesencephalic Dopaminergic (DA) Neurons In vivo and In Vitro. Intranigral injection of the 6-OHDA into the rat brain, or treatment of rat mesencephalic cultures with 6-OHDA, resulted …

    ajou Repository record

  18. Molecular mechanisms involved in the regulation of beta-cell viability by Signal Regulatory Protein-Alpha (SIRPα)

    Abdullah Alatawi (21042413)2026

    … (operating via cytokines such as Interleukin-13 (IL-13)) are downregulated. IL-13 has been shown to protect β-cell viability via STAT6 signalling, and preliminary data suggested that Signal Regulatory Protein-α (SIRPα) also plays a vital part in this protective effect. However, the protective …

    exeter

  19. Der Einfluss von HLA-G und HLA-E auf Large Granular Lymphocytes

    Probe, ChristineUniversität Würzburg

    … der Sekretion der Zytokine TNF-a, IFN-g, GM-CSF, IL-5, IL-10, IL-13 und IL-15 gemessen. Dabei zeigte die Chorionkarzinomzelllinie JEG-3 eine Unterdrückung der TNF-a-, IFN-g-, GM-CSF- und IL-13-Produktion, aber eine Erhöhung der IL-10- und IL-15-Produktion gegenüber JAR. Möglicherweise tragen aber …

    wurz-thes Repository record

  20. Az atópiás dermatitis legújabb szisztémás kezelési lehetőségei

    Illésy, Márton2022

    … bizonyultak. A JAK gátlók kedvező mellékhatásprofillal rendelkeznek és a betegség tüneteinek gyors enyhülését is elősegítik. Az AD modern kezelésének másik célpontja a biológia terápiák csoportjába tartozó monoklonális antitestek, a dupilumab és a tralokinumab. Az AD patomechanizmusának egy …

    debrecen Repository record

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