Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 168 for “"IL-12"”.
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Plant-derived Murine IL-12 and Ricin B-Murine IL-12 Fusions
Interleukin-12 (IL-12), an important immuno-modulator for cell-mediated immunity, shows significant potential as a vaccine adjuvant and anti-cancer therapeutic. However, its clinical application is limited by lack of an effective bioproduction system and by toxicity associated with systemic …
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Regulation of Human Cytotoxic T Lymphocyte Functions by IL-12
… by secreting effector cytokines and directly killing infected cells. Upon sensing of pathogen, antigen presenting cells secrete innate cytokines such as IL-12 and IFN-α. CTL functions are specified by both antigen recognition and innate cytokines yielding a diverse population comprised of …
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Vaccinia Virus-Mediated Glioma Gene Therapy Using p53, IL-2 and IL-12
… combining immunotherapy with interleukin (IL)-2 and interleukin (IL)-12 and a tumor suppressor (p53). We propose the <em>hypothesis</em> that this specific combination of therapeutic genes has a synergistic inhibitory effect on glioma growth and describe a <em>mechanism</em> to account for …
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Batf3-Deficient Mice: Susceptibility to Toxoplasma gondii and Responses to IL-12 Treatment in vivo
… and tumors. Additionally, stimulation of IL-12 production by CD8α<super>+</super> DCs has suggested a role for these cells in response to <italic>Toxoplasma gondii</italic> antigens, although no experiments have yet shown an <italic>in vivo</italic> requirement for these cells …
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Identification of toxoplasma gondii genes involved in the strain-specific modulation of IL-12 cytokine secretion
… the stimulation of high levels of interleukin- 12 (IL- 12), followed by the production of interferon-y (IFN-y) by immune cells. Although IFN-y is the main mediator of resistance to Toxoplasma infection, Toxoplasma is able to manipulate the immune response through the regulation of IL- 12 …
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Simultaneous Induction of Nkg2D and Nkg2D Ligand For Promoting Immune Surveillance By Il-12 Plus Doxorubicin Treatment
<p>NKG2D (natural killer group 2, member D) and its ligands interaction in tumor microenvironment directs tumor infiltrating immune cells to recognize tumor cells, stimulate cytotoxic effector immune cells, and therefore eradicate tumor cells. IL-12, a cytokine produced by antigen presenting cells, …
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Characterization of an IL-12-driven Anticancer Response, and the CD4+ CTL Population Incited, in a Murine Model of Leukaemia
… Th1 polarizing cytokine, interleukin-12 (IL-12) holds much promise; however, optimal therapeutic protocols have yet to be developed and clinical results have fallen short of this promise. The in vivo IL-12 experiments described here highlight a characteristic of cellular therapy that …
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Delineating The Roles of IL-12 and IL-23 Produced by Dendritic Cells in Eliciting CD8+ T Cell Resonses Against Listeria Monocytogenes
Interleukin-12 family members are important links between innate and adaptive immunity. IL-12 drives Th1 responses by augmenting IFN-γ production – key for clearance of intracellular pathogens. IL-23 promotes the development of IL-17 producing CD4+ T cells that participate in the control of …
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Infecção, in vitro, por Staphylococcus aureus meticilina-sensível e meticilina-resistente: produção de IL-12, IFN-γ e IL-10 por macrófagos/linfócitos de ratos submetidos à desnutrição neonatal
Staphylococcus aureus resistentes a meticilina constituem um grave problema para a saúde mundial. Alguns fatores relacionados às condições do hospedeiro predispõem às infecções por esses micro-organismos, dentre eles destaca-se a desnutrição. Assim, torna-se importante avaliar repercussões da …
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Interleukin-10 und Interleukin-12 produzierende Monozyten-Subpopulationen bei Normalpersonen und Probanden mit atopischer Diathese
… Arbeit wurde die monozytäre Produktion von IL-10 und IL-12 untersucht. IL-12 ist ein proinflammatorisches Zytokin, das die zellvermittelte Abwehr aktiviert und TH1 Immunantworten induziert. IL-10 wirkt antagonistisch zu IL-12, indem es die Synthese zahlreicher Entzündungsmediatoren …
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Der Einfluß zerebraler Expression von Interleukin-12 auf die neonatale Borna Disease Virus Infektion bei Mäusen
Expression von biologisch aktivem Interleukin-12 (IL-12) in Astrozyten des zentralen Nervensystems (ZNS) führt zu einer spontanen neuroimmunologischen Erkrankung von Mäusen. Das Borna disease Virus (BDV) kann sich im ZNS der Maus vermehren, löst aber in den meisten Mausstämmen keine Erkrankung aus. …
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Characterizing the pro-inflammatory cytokine response by dendritic cells upon exposure to PrP proteins
… of PrPSc on DC activation by measuring TNFα and IL-12 production. There was no significant production of TNFα or IL-12 by bone marrow derived DCs (BMDC) after exposure to PrPSc infected brain homogenate, however, BMDCs had lower capacity to produce IL-12 after secondary stimulation with LPS. …
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Studies of human T cell costimulation: potential for the immunotherapy of cancer
… CD80 and 4-1BBL (CD137L) and the cytokine IL-12 tumour cell lines were transduced to express these molecules individually or in combination in vitro. Using PBMC from healthy donors the effect of costimulation in response to pan-T cell stimulation with the anti-CD3 antibody OKT-3 were …
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HER2 and Folate Receptor Targeted Therapy is Enhanced by NK Cell-Activating Cytokines
… receptors (FcR) for immunoglobulin G. Natural killer (NK) cells are innate immune effector cells that play a crucial role in cancer rejection and immunosurveillance. Importantly NK cells express the Fcgamma receptor IIIa (FcgammaRIIIa) and various cytokine receptors, which can be activated upon …
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Chitosan Decontamination with Non-Thermal Nitrogen Plasma to Enable Internal Use
… used as a topical hemostatic agent due to an inability to sterilize and depyrogenate chitosan without negatively altering its physical and biological properties with conventional techniques. We hypothesized that non-thermal nitrogen plasma (NtNP) would sterilize and depyrogenate chitosan while …
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Reciprocal Regulation of CD4+ and CD8+ T Lymphocyte Effector and Memory Fates by Interleukin 12 and Type 1 Interferon
… For example, the innate cytokines Interleukin-12 (IL-12) and type I interferon (IFN-a/b) are induced to high levels by intracellular bacterial and viral infections and have been shown to promote adaptive T lymphocyte responses to infection. While the role for IL-12 on the development of T …
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Paclitaxel-induced macrophage activities in the tumor-bearing host: immunologic implications and therapeutic applications
… of the immunostimulatory cytokine interleukin-12 (IL-12). Concurrently, paclitaxel induces Mf cytotoxic and proinflammatory molecule production, including tumor necrosis factor-a and interleukin-1b. In contrast to its apparent immunotherapeutic effect on Mf populations, paclitaxel's cytostatic …
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Determination of the role of cytokines using gene deficient mice in African trypanosomiasis infection
… alike. To determine the immunological role of IL=12 family members in Trypanosoma brucei brucei, Trypanosoma evansi and Trypanosoma congolense infections, IL-12p35¯/¯, IL-12p40¯/¯ and IL-12p35¯/¯/p40¯/¯ mice were used. While the two latter mouse strains lack all IL-12 homologues, IL-12p35¯/¯ …
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Regulation of Effector and Memory Development of Human CD4+ T Cells by Interleukin 12 and Type I Interferon
… For instance, the innate cytokines interleukin 12 (IL-12) and type I interferon (IFN-alpha/beta) are produced in response to intracellular bacterial and viral infections. While the effects of IL-12 on CD4+ T cell differentiation are relatively well-understood, the role of IFN-alpha/beta, despite …
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Layer-by-Layer Nanoparticles for Cytokine Delivery
… cancer treatment. However, immunotherapy has failed to improve responses in certain cancers such as ovarian cancer (OC). The action of cytokines in the tumor microenvironment (TME) is key to regulating immune responses, but dose-limiting toxicities limit the application of cytokines in cancer …
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