Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"IL-11"”.
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STAT-3-Aktivierung in humanen endometrialen Primärzellkulturen durch LIF und IL-11
Leukemia inhibitory factor (LIF) and Interleukin (IL) 11, two cytokines of the IL-6 Family, have been identified as regulatory molecules during blastocyst implantation in mice. IL-11 knock out (k.o.) mice, as well as LIF Rß k.o. mice demonstrated fertility problems. Thus the hypothesis was …
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Untersuchungen zur Zytokinbindung und Rezeptoraktivierung des Signaltransduktors gp130 durch seine Liganden IL-6 und IL-11
… the central signal transducing subunit of the family of IL-6-type cytokines thereby initiating several biological responses. The aim of this work was to characterize the properties of ligand binding and activation of gp130 in detail: - Two different binding epitopes are required for ligand binding …
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Struktur- und Funktionsuntersuchungen am humanen Interleukin-11-Rezeptorkomplex
Interleukin-11 (IL-11) belongs to the interleukin-6 (IL-6)-type subfamily of long-chain helical cytokines, which all share the glycoprotein gp130 as a signal transducing receptor component. IL-11 acts on cells expressing gp130 and the IL-11 receptor (IL-11R) alpha-subunit (IL-11R-alpha). The third …
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RET receptor activation targets expression of the pleiotropic cytokine interleukin-11
… by gene rearrangements are associated with papillary thyroid carcinoma (PTC). In gene expression screens, interleukin-11 was identified as a RET-responsive gene. We sought to characterize the expression of IL-11 in response to activation of the RET receptor, and determine how IL-11 might …
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Role of vascular smooth muscle Interleukin-11 in aortic aneurysm development
… treatment options. Our laboratory examined wild-type (WT) and BCL11B knockout (BSMKO) mice treated with Angiotensin II (AngII) for a period of 7 days. The BSMKO mice given AngII exhibited aneurysm formation, while the WT mice did not show this response. RNA sequencing of entire aortas from …
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Cytokines and human endometrial function: Abnormalities in recurrent miscarriage women.
… The role of cytokines in the human endometrium still remains to be determined, but they are thought to play an important role in the implantation process. This study has therefore focused on the expression of pro-inflammatory cytokines in the human endometrium and effects of these cytokines on …
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Investigating the Role of the PGF2 Alpha/Calcineurin-Signaling Pathway in the Regulation of Adipogenesis
… have now extended these findings to identify the IL-11 cytokine and the Nurr1 orphan nuclear hormone receptor as functionally important downstream transcriptional targets of the PGF2α/calcineurin-pathway involved in the inhibition of adipocyte differentiation. In the case of IL-11, we show …
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Struktur- und Funktionsanalyse der zytokinbindenden Domäne des humanen Interleukin-11-Rezeptors
The interleukin-11 receptor (IL-11R) belongs to the hematopoietic receptor superfamily. The functional receptor complex comprises IL-11, IL-11R and the signal-transducing subunit gp130. The extracellular part of the IL-11R consists of three domains: an N-terminal immunoglobulin-like domain, D1, and …
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Characterization of signalling cross-talk between the EP2 and FP receptors in endometrial epithelial cells
… and prolactin were not significantly altered while the EP3 subtype receptor was significantly down-regulated in fibroids compared to adjacent myometrium samples. The EP3 receptor has a protective role in tumor development suggesting the role for down-regulation of the receptor in uterine …
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MICRORNAs AS PREDICTIVE AND THERAPEUTIC TOOLS IN PROSTATE CANCER AND BONE METASTASIS
Il carcinoma della prostata è una delle malattie più comuni ed è nell uomo, la principale causa di morte dovuta a patologie neoplastiche. Nonostante i significativi progressi nella diagnosi e nel trattamento dei tumori precoci, la validazione di nuovi biomarcatori, in grado di distinguere tra …
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Charakterisierung fluoreszierender Varianten des Zytokinrezeptors gp130 hinsichtlich biologischer Aktivität und Dimerisierung mit molekularbiologischen und fluoreszenzspektroskopischen Methoden
… signal transducer component of the cytokines IL-6, IL-11, LIF, CNTF, OSM and CT-1 the behaviour of gp130 towards its ligands is of major interest. For IL-6 the cell surface complex, which is necessary to start the intracellular signal cascade, is composed out of the ligand, the specific …
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Novel cytokines in innate immunity: IL-27 and IL-30 enhance responsiveness to gram-negative bacterial components in human myeloid cells
… This thesis investigates two related cytokines, IL-27 and IL-30, to identify novel proinflammatory mechanisms to improve treatments for bacterial infections. IL-27 is comprised of IL-27p28 and EBI3 subunits; the IL-27p28 subunit, also named IL-30, can also signal independently of EBI3. To date, …
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Expression and function of the αVβ5 integrin during human B lymphopoiesis
… cell lines. The pre-B cell lines SMS-SB, RS4;11 and 697 showed a significant proliferative response to αVβ5 stimulation by sCD23, a sCD23-derived long peptide and anti-αVβ5 MAb 15F11. Transitional and more mature B cell lines down-regulated αVβ5 expression and did not show a proliferative …
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The Role of Platelets In Ovarian Carcinoma
… factors including thrombopoietin (TPO), IL-1a, IL-3, IL-4, IL-6, IL-11, G-CSF, GM-CSF, stem cell factor, and FLT-3 ligand were assayed in a subset of 150 patients at the time of initial diagnosis with advanced stage, high grade epithelial ovarian cancer using immunobead-based cytokine …
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Color stability and phenolic composition from corn pericarp extracts in a beverage model and protective and anti-inflammatory potential of anthocyanin-rich plant extracts on celiac disease in vitro
… objective of phase I was to evaluate color stability of nine anthocyanin-rich color corn variety pericarp extracts and the objectives of phase II were to evaluate the potential of anthocyanin-rich plant extracts to protect human epithelial cells against a celiac toxic peptide (CTP) and to …
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Entwicklung und Charakterisierung eines IL-6-Inhibitors basierend auf Funktionsanalysen des murinen IL-6R alpha
… and induce a multitude of biological effects. IL-6-type cytokine family members activate the Jak/STAT signalling pathway and hence modulate processes such as apoptosis, proliferation, angiogenesis and migration of cells. The cytokine IL-6 possesses great clinical relevance because dysregulation …
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Peripheral inflammatory and regulatory immune changes in HIV positive to HIV positive renal transplant recipients
… donors to HIV positive recipients with renal failure predominantly due to HIV-associated Nephropathy (HIVAN). Recipients received Anti-thymocyte globulin (ATG) induction therapy and maintenance immunosuppression. Despite transplantation across Human Leukocyte Antigen (HLA) mismatches, there were …
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Expression von Zytokinrezeptoren, Adhäsionsmolekülen und kostimulatorischen Molekülen und deren klinische Relevanz bei der akuten myeloischen Leukämie
… Hämopoese exprimiert werden, wie der SCF-R (CD117), FL-R (CD135), IL-3-R (CD123) und zum andern Zytokinrezeptoren, die erst in späteren Differenzierungsstadien der monozytären Zelllinie (v.a. GM-CSF-R; CD116) und der granulozytären Zelllinie (v.a. G-CSF-R, CD114) exprimiert werden. Die …