Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"IL-1 beta"”.
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Adult articular cartilage culture system and effects of IL-1[beta]
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1996.
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Zeit- und konzentrationsabhängige Modulation der VEGF-Genexpression und der VEGF-Proteinmenge durch TNF[alpha] IL-1[beta], IL-6, EGF und TGF-[beta]1 in Ovarialkarzinomzellinien
… of the cytokines and growth factors TNF-alpha, IL-1beta, IL-6, EGF and TGF- beta 1 in regards to the VEGF- expression of the ovarian cancer cell lines BG-1, HEY and SKOV-3 by northern- analysis and ELISA. The stimulation with cytokines and growth factors resulted in minimal or not detectable …
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Anti-Inflammatory Effect of Adipose-Derived Mesenchymal Stem Cells for Flexor Tendon Healing
… remain prone to poor clinical outcomes. While previous attempts to improve flexor tendon healing have focused on the later stages of healing: i.e., proliferation and matrix synthesis), the early inflammatory phase of tendon healing remains poorly understood and its modulation during healing …
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Inhibition des nukleären Transkriptionsfaktors kappa B (NF-Kappa B) durch die kurzkettige Fettsäure Butyrat
… proinflammatorisch wirkender Genprodukte beteiligt. Durch Mediatoren wie TNF alpha oder IL-1 beta wird eine nukleäre Translokation von normalerweise im Zytoplasma an inhibitorische I kappa B-Proteine gebundenem NF-kappa B hervorgerufen. Im Rahmen der CU ist NF-kappa B u. a. in Lamina …
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Untersuchungen zur Rolle von Zytokinen bei der Beta-2-Mikroglobulin-Synthese in verschiedenen humanen Zelltypen
… monocytic cytokines such as interleukin-1 (IL-1), tumour necrosis factor-alpha (TNF-alpha) and IL-6 have been incriminated in the pathogenesis of elevated beta-2-microglobulin (beta-2-M) serum concentrations in patients undergoing haemodialysis with so-called bioincompatible dialyser …
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Bedeutung von DNS-Polymorphismen bei Arthrose
… im Arthrose-Prozess eine große Bedeutung haben: Il-1 alpha, Il-1 beta, TNF alpha und MMP-3 (Stromelysin). Viele bereits durchgeführte Studien lieferten widersprüchliche Ergebnisse, wiesen zu geringe Fallzahlen auf oder definierten die Kollektive nur unzureichend. Ziel dieser Studie war es klar …
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Thalidomid und Rolipram führen zu funktionell relevanten Verbesserungen der Motorik nach traumatischen Rückenmarksverletzungen bei der Ratte
… factor alpha (TNF alpha) and interleukin-1 beta (IL-1 beta) play important roles during the early hours after injury. This period of secondary tissue degeneration presents an early therapeutic window of opportunity, during which intervention strategies directed at reducing the influence of …
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Zytokinexpression in der ischämischen Penumbra nach transientem Verschluß der A. cerebri media in der Ratte
… artery (MCA-O) in rats. The animals were killed at 1, 3, 7 or 14 days following operation. Coronal brain sections were processed for astroglial (GFAP), microglial (OX 42), cytokin (IL-1-beta, IL-6, TNF-alpha), and apoptotic (TUNEL) markers, for i-NOS and n-NOS activity, and NISSL-staining. …
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Long-term effects of LPS and high-fat diet on dopaminergic neurodegeneration
… In the current study, it is hypothesized that IL-1 beta, a potent proinflammatory cytokine synthesized and released by glia cells, could be mediating the LPS-induced dopaminergic neurodegeneration and that the chronic low-grade inflammatory state caused by diet-induced obesity would exacerbate …
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Long-term effects of LPS and high-fat diet on dopaminergic neurodegeneration
… In the current study, it is hypothesized that IL-1 beta, a potent proinflammatory cytokine synthesized and released by glia cells, could be mediating the LPS-induced dopaminergic neurodegeneration and that the chronic low-grade inflammatory state caused by diet-induced obesity would exacerbate …
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Rodent inflammasome activation by Toxoplasma gondii
… chronic infection relies on the parasite's ability to find a balance between activation of a host immune response and evasion of parasiticidal mechanisms. This balance is achieved through the modulation of host cell processes by parasite proteins secreted from specialized secretory organelles …
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Charakterisierung von IL-4 Knockout-Mäusen und ihrer Zytokin- und Opioidrezeptor-Expression im peripheren und zentralen Nervensystem
… des antiinflammatorischen Zytokins Interleukin(IL)-4 am Tiermodell einer experimentellen Mononeuropathie (engl. chronic constriction injury, CCI) untersucht. Zentrale Fragestellung der Studie war, ob IL-4 knockout(ko)-Mäuse im Vergleich zu Wildtyp(wt)-Mäusen mit einem gesteigerten …
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A quantitative proteomics study of the additive effect of inflammatory cytokines and injurious compression on cartilage damage
… released to media on combination with cytokine (IL-1[beta[ or TNF-[alpha]) and Injury as compared to either treatment alone, and to thus identify proteins which may be responsible for the synergism seen between cytokine and injury in causing catabolism of cartilage in vitro. 2) To identify …
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The role of inflammasomes in a murine model of acute respiratory distress syndrome (ARDS)
… pulmonary inflammation that can cause organ failure which is commonly caused by sepsis, severe pneumonia and trauma. ARDS has become one of the top research priorities since the SARS-CoV-2 outbreak in 2020. From injury to damaged tissue repair, cell proliferation is a mandatory mechanistic …
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Development of a novel in vitro model to study the tryptic : endothelial cells, monocytes and flow
… the endothelial dysfunctional state. We built and integrated our in vitro model to a unique flow apparatus that can precisely replicate atheroprone and atheroprotective shear stress waveforms. We carefully characterized the model that relies on a fibronectin-coated collagenous matrix seeded …
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Autophagy and Inflammation During Rickettsial Infection
… of several proinflammatory cytokines including IL-1α, IL-6 and TNF-α and the inflammasome-dependent IL-1β when infected with rickettsiae, suggesting that autophagy suppresses the induction of these inflammatory cytokines. To investigate the regulation of autophagy induced by rickettsiae, I …
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