Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 338 for “"IL-1β"”.
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Retroviral-mediated gene transfer of Il-1β?cDNA into human activated T cells
Autologous activated T cells (ATC) are being utilized in clinical trials as potential mediators of anti-tumor cytotoxicity in refractory cancer patients who suffer from hematologic malignancies or solid tumors. ATC are readily generated from peripheral blood and possess non-major histocompatibility …
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Statins Regulate IL-1β - Induced RANKL and OPG Production by Human Gingival Fibroblasts
… factor (TNF) ligand and receptor superfamilies, regulate the process of osteoclast formation. The first one, receptor activator for NF- kB ligand (RANKL) is expressed on hematopoetic stromal cells and periosteal osteoblasts as well as on HGF and PDL cells. RANKL interacts with its …
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Entamoeba histolytica-Induced Caspase-4 Activation Regulates IL-1β Secretion Through Caspase-1
… Surprisingly, caspase-4 activation was similar to caspase-1 requiring live Eh attachment via the Gal-lectin, EhCP-A5 and cellular stresses such as K+ efflux and ROS. However, unlike caspase-1, caspase-4 activation was independent of ASC and NLRP3. Using CRISPR/Cas9 gene editing of caspase-4 …
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The Effect of Obesity on IL-1β, IL-1Ra, and Leptin Following Acute Mental Stress
… Specifically, this study aims to address IL-1β, IL-1Ra, and leptin following an AMS task in non-obese and obese individuals. Additionally, a manuscript is included which evaluates the change in IL-1β, IL-1Ra, and leptin following a 20 minute AMS task. Variables were examined between groups …
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Ο ρόλος της αναστολής της ιντερλευκίνης 1β (IL-1β) στην εκφυλιστική νόσο του μεσοσπονδύλιου δίσκου
… ερευνητικές μελέτες, ορισμένες κυτοκίνες όπως η IL-1β, φαίνεται πως διαδραματίζουν σημαντικό ρόλο στην έναρξη και την εξέλιξη της εκφύλισης του μεσοσπονδύλιου δίσκου. Συγκεκριμένα, η IL-1β είναι μια κυτοκίνη που ανήκει στην οικογένεια των ιντερλευκινών και λειτουργεί ως προωθητικός παράγοντας της …
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Fibrosarcoma-induced Dysregulation of Interleukin (IL)-1β and IL-18 Activities and their Modulation by Paclitaxel
Cancer remains an elusive killer due, in part, to the suppression of normal immunologic antitumor responses. Normal host (NH) macrophage (Mϕ) populations have tumoricidal effects such as tumor antigen phagocytosis and presentation, and cytokine production. Tumor-infiltrating Mϕs may evade these …
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Exploring the Role of IL-1β/IL-1R in the Pathogenesis of K-ras Mutant Lung Cancer
… Notably, the pro-inflammatory cytokine IL-1β a potent activator and product of the NF-κB pathway is elevated in the lungs and sera of KM-LUAD patients. We have shown that IL-1β blockade promotes an anti-tumor immune phenotype in a mouse model of KM-LUAD driven by lung epithelial …
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Entamoeba histolytica-induced Activation of Caspase-4 Regulates Gasdermin D Cleavage to Mediate IL-1β Secretion in Macrophages
… Entamoeba histolytica (Eh) is named for its capability to lyse healthy host tissues. A hallmark of Eh invasion in the gut is acute intestinal inflammation dominated by the secretion of pro-inflammatory cytokines. Eh in direct contact with macrophages activates caspase-1 by the assembly of the …
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Wirkung der proinflammatorischen Zytokine TNFα und IL-1β auf die Aktivität und die Proteinmenge der Dual-Leucine-Zipper-Bearing Kinase in einer Betazelllinie
… Die proinflammatorischen Zytokine TNFα und IL-1β sind dabei wichtige pathogene Effektoren, wobei die Signaltransduktion, über die sie auf die Betazellen wirken, noch nicht vollständig geklärt ist. Die MAP3K DLK ist eine wichtige Komponente in der Regulation des programmierten Zelltodes, da …
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IL-1β Amplification of Nitric Oxide Production and Its Inhibitory Effects on Glucose Induced Early Growth Response-1 Expression in INS-1 Cells
… pathophysiology of cytokines released by infiltrating white blood cells upon pancreatic beta cells is not fully understood. Early growth response gene-1 (Egr-1) expression is specifically and transiently up regulated in pancreatic beta cells in response to glucose. We hypothesized that …
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Studies on the production of IL-1β, TNF-α, iNOS, IL-10, and ROS in the APP/PS1 mouse model of Alzheimer's disease
… demonstrated the neuroprotective effects of IL-10 in LPS-injected rat cerebral cortex, which was mediated by inhibition of NADPH oxidase activation and pro-inflammatory mediators expression. Here, we observed the expression of pro-inflammatory mediators and IL-10 in the cerebral cortex of …
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Atypical Mechanisms of Synthesis, Activation and Release of Interleukin-1β from Vascular Smooth Muscle Cells
… of atherosclerosis in humans and animal models. IL-1β is a potent inflammatory cytokine implicated in atherogenesis and other vascular diseases. However, control of its activation and release has been predominantly studied in macrophages, with scant data on whether vascular smooth muscle cells …
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Neuromodulation by endogenous Interlukin-1β in hippocampus of the murine brain: Regulation of neuronal excitation
<p>The pro-inflammatory cytokine, Interleukin-1β (IL-1β), is well known for its ability to initiate and propagate inflammatory responses at sites of infection and tissue injury. Paradoxically at odds with this classic view, it is now clear that IL-1β signaling modulates a number of physiological …
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Role of Protein Phosphatase-2A in Regulating Monocyte Activation by Soluble and Crystalline Uric Acid in Gout
… expression and production of interleukin-1 beta (IL-1β) and chemokines. The activation of monocytes by MSU crystals involves the priming of monocytes with danger signals e.g. lipopolysaccharide (LPS) or soluble uric acid (UA), crystal phagocytosis and subsequent NLRP3 inflammasome activation and …
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The role of vector-derived microbiota and co-localization in the dissemination of vector transmitted pathogens
… and treatment strategies due to the ability of Leishmania spp. parasites to disseminate from the initial site of infection in the skin to the internal organs following transmission by the bite of an infected sand fly vector. This study investigated the role of inoculation method and the …
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SCI-Induced Chronic Pain is Driven by a Central to Peripheral IL-1 Mediated Signaling Pathway
… Research has also shown that interleukin-1β (IL-1β) is released from the site of SCI within hours of injury, but there is still a significant gap in our knowledge of its role in the development of chronic SCI pain. Recent whole transcriptome RNA sequencing performed by our laboratory has …
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Inflammasome activation in THP-1 target cells triggered by pathogenic Naegleria fowleri
… under the non-contact system, and consequently IL-1β production was estimated. By western blotting and ELISA analysis, the caspase-1 activation and IL-1β production from THP-1 cells and the culture supernatant were observed 3 hr after co-cultivation. In addition, the increased expression of ASC …
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