Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"IL-1α"”.
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Il-1Α Blockade Reduces Immune Suppression In The Early Tumor Micro-Environment
<p>IL-1α Blockade Reduces Immune Suppression in the Early Tumor Micro-Environment</p> <p>Brenda Melendez, B.S.</p> <p>Advisory Professor: Gregory Lizee, PhD.</p> <p>Immunotherapy against melanoma has shown great promise in the clinic for treating advanced-stage patients. However, a major barrier …
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Investigating the role of histone H3 lysine 9 dimethylation in regulating disease-associated vascular smooth muscle cell gene expression
… disease. Upon insult, VSMCs downregulate contractile proteins and upregulate genes linked to vascular remodelling, such as matrix metalloproteinases (MMPs) and pro-inflammatory cytokines. However, the epigenetic mechanisms which regulate VSMC phenotypic switching remain unclear. This thesis …
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An Investigation into the Effects of Macrophage Polarisation on Interleukin-1 Expression
… heterogeneity and plasticity. The prevailing dogma divides macrophages into two opposing subtypes: the pro-inflammatory M1 and anti-inflammatory M2 macrophages. Macrophages are also the main cell type that produces two powerful cytokines that drive chronic inflammation and adaptive …
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Steroid signalling in the human ovarian surface epithelium wound healing
… tissues. Of the cytokines tested, only IL-1α and IL-4 affected 3β-HSD expression. IL- 1α suppressed 3β-HSD1 mRNA, whereas it up-regulated 3β-HSD2 mRNA as assessed with qPCR, without though affecting total 3β-HSD protein and activity levels as assessed with western immunoblotting and …
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SCI-Induced Chronic Pain is Driven by a Central to Peripheral IL-1 Mediated Signaling Pathway
… Research has also shown that interleukin-1β (IL-1β) is released from the site of SCI within hours of injury, but there is still a significant gap in our knowledge of its role in the development of chronic SCI pain. Recent whole transcriptome RNA sequencing performed by our laboratory has shown …
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Roles For Braf Kinase Activating Mutations In Melanoma: Microenvironmental Immunosuppression
… that BRAF(V600E) induces transcription of the IL-1α and IL-1β genes in both melanocytes and melanoma cell lines and that this upregulation is specifically abrogated by targeted BRAF(V600E) inhibitors. Furthermore, treatment of melanoma tumor-associated fibroblasts (TAFs) with IL-1α/β …
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Macrophage Response to Interleukin-1 Stimulation and the Nature of Cell Surface Interleukin-1 Alpha
Interleukin-1α (IL-1α) is a potent cytokine involved in a range of diseases and can be found expressed on the cell surface (csIL-1α) and in the soluble form, signalling through the type I IL-1 receptor (IL-1R1). IL-1 signalling leads to increased secretion of cytokines, recruitment of immune cells …
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The role of fibrolast-derived cytokines on melasma
… of melasma. We collected the specimens of perilesional normal site and lesional site by 2 mm punch biopsy technique on the faces of 50 melasma patients. We performed on the specimens to stain of hematoxylin-eosin, Fontana-Masson, Masson trichrome, Verhoeff-van Gieson and immunohistochemical …
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An Infection Model for Examining the Effects of Gender and Diabetic State on Proinflammatory Cytokine Secretion by Phagocytic Cells in Response to Infection with Burkholderia pseudomallei
… pseudomallei is an opportunistic soil pathogen that causes melioidosis, a life-threatening human disease prevalent in Southeast Asia, northern Australia, the Middle East, Africa, and South America. The organism also causes disease in plants and animals. Persons with severe …
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Systemic Cytokine Expression and Endothelial Dysfunction: Insights from Innate Immune Models of Protein Phosphorylation
… tumour necrosis factor (TNF) and interleukin-6 (IL-6) and adverse cardiovascular events. However, the early pathophysiological signalling responsible for the expression of inflammatory molecules in vascular dysfunction remains poorly defined with limited in vivo studies. The ability to quantify …
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Úloha cytokinů v podpoře maligních vlastností glioblastomů
… role of selected cytokines of the SASP (IL-6, IL-1β, IL-8, IL-1α, TGF-β, CCL2, TNF-α) in support of the malignant properties of GB. Key words: glioblastoma (GB), senescence, SASP, malignant properties, cytokines
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The Immune Modulatory Effects of Tylvalosin in Porcine Neutrophils and Macrophages in vitro
… by elucidating its effects, in isolated neutrophils and monocyte-derived macrophages from piglets. Our findings indicate that TYL increases porcine neutrophil and macrophage apoptosis in a dose-dependent and time-dependent manners, without affecting levels of necrosis. TYL also modulates …
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Characterization of cathepsin B cysteine protease from Naegleria fowleri excretory-secretory proteins exerting immunomodulatory effects
… cells. Several cytokines, particularly IL-1α and TNF- α were highly up-regulated by Nf-ESPs. Also, activation of P38 and JNK was observed in BV2 cells treated with Nf-ESPs. The results collectively suggest that Nf-ESPs may play an important role in N. fowleri mediated-PAM through …
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The association between interleukin-1 gene polymorphism and periodontitis in adults in Africa: A systematic review
… tissue, is a global oral health concern. While bacterial infections initiate the problem, the body's inflammatory response impacts disease progression. Interleukin-1 (IL-1), a group of molecules known as pro-inflammatory cytokines, has emerged as a critical factor in periodontitis …
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Immunological and behavioral consequences of high-fat diet feeding in mice
… that obese mice fed a high-fat diet (HFD), fail to exhibit an interest in saccharin (27% vs 74%) compared to mice fed a low-fat diet (LFD) (p < 0.007). When HFD mice undergo a fasting period of 24 hours, saccharin preferences equilibrate to water consumption (51% saccharin vs 49% water). Other …
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Studies of immunoglobulin receptors and human proximal tubular cells
… is a major cause of progressive chronic renal failure (CRF) and accounts for less than 20% in the UK of patients requiring dialysis and transplantation. There are many forms of GN, of which IgA nephropathy (IgAN) is the most common, affecting up to 2% of the adult population. GN is characterised …
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The effect of fasting on anti-inflammatory mediators, IL-1RA and IL-1R2, and their role in resistance to sickness behaviors in mice
… (24 h water-only fast) is able to attenuate IL-1β-induced anorexia, in addition to other sickness behaviors at early stages of the acute phase response. We previously reported that fasting was able to reduce gene expression of inflammatory IL-1α in the brain, here we looked at liver and …
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The effect of RAN inhibition on human colorectal cancer cells (CRC)
… K-Ras, DLD-1 K-Ras and Pten deletion and wild type HCT-116 and DKO-3. I used qRT-PCR and western blotting to identify expression levels of various genes and signalling molecules after treatment with 0.5 mM MBZ. In addition, several assays were performed to investigate MBZ effect on …
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Atypical Mechanisms of Synthesis, Activation and Release of Interleukin-1β from Vascular Smooth Muscle Cells
… of atherosclerosis in humans and animal models. IL-1β is a potent inflammatory cytokine implicated in atherogenesis and other vascular diseases. However, control of its activation and release has been predominantly studied in macrophages, with scant data on whether vascular smooth muscle cells …
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Descripción de la microbiota fúngica presente en el tracto respiratorio de sujetos con enfermedad pulmonar obstructiva crónica
… como Pneumocystis pueden alterar los valores de IL-8, IL-6 y TNF- a nivel sistémico en sujetos colonizados y posiblemente influir en la fisiopatología de la EPOC. Por otro lado, estudios recientes han demostrado que los β-glucanos, componente estructural principal de la pared celular de la …
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