Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"IL-1â"”.
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Roles of interleukin-1 beta in glutamate-induced spinal cord injury
… toxicity involving activation of interleukin-1â (IL-1â). To assess the effects of glutamate on IL-1â and its natural blocking agent interleukin-1 receptor antagonist (IL-1ra), ELISA assays were used to measure the responses of endogenous IL-1â and IL-1ra to glutamate administered to the spinal …
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Mechanisms of increased microvascular permeability during acute Rickettsiosis
… fever and epidemic typhus. Rickettsiae primarily target the microvascular endothelium leading to increased microvascular permeability, the mechanisms of which are completely unknown. We sought to determine the impact of host responses to infection on increasing microvascular permeability both …
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Effect of Medicinal Herbal, Panax Notoginseng, on the Fate and Function of Professional Antigen Presenting Cells
… relative to LPS stimulation. LPS induced IL-1â, IL-6 and IL-12 production was also decreased with concurrent notoginseng treatment for 24 hours. Notoginseng decreased TNF-á and CD40 activation by CpG and poly(I:C), but had varied effects on the induction of IL-6 and CD86. Furthermore, …
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Effect of Medicinal Herbal, Panax Notoginseng, on the Fate and Function of Professional Antigen Presenting Cells
… relative to LPS stimulation. LPS induced IL-1â, IL-6 and IL-12 production was also decreased with concurrent notoginseng treatment for 24 hours. Notoginseng decreased TNF-á and CD40 activation by CpG and poly(I:C), but had varied effects on the induction of IL-6 and CD86. Furthermore, …
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Consequences of Aryl Hydrocarbon Receptor Activation in Crohn's Disease
… state of the gastrointestinal tract, affects millions worldwide; however, the exact cause is unknown and treatments do not cure the disease. The role of the AhR in mucosal immune responses is not well understood to date so we aimed to understand the consequences of AhR activation in gut …
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Consequences of Aryl Hydrocarbon Receptor Activation in Crohn's Disease
… state of the gastrointestinal tract, affects millions worldwide; however, the exact cause is unknown and treatments do not cure the disease. The role of the AhR in mucosal immune responses is not well understood to date so we aimed to understand the consequences of AhR activation in gut …
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Mechanisms Of Cytokine-Induced Metabolic Dysfunction Of The Pancreatic Beta-Cell
… Sciences</p> <p>Degree: Doctor of Philosophy</p> <p>Type I diabetes is characterized by an absolute insulin deficiency due to loss of pancreatic â-cell mass by autoimmune aggression. During the progression of the disease proinflammatory cytokines such as IL-1â, TNFá and INFã are …
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ROLE OF NOTCH SIGNALING IN BREAST CANCER METASTASIS
… progression. We have analyzed the expression profiles of various Notch liagnds in 779 breast cancer patients in GEO database and found that the expression of Jagged2 among all five ligands is most significantly correlated with the overall- and metastasis-free survival of breast cancer patients. …