Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"IL-1ß"”.
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Periventricular white matter damage in the post-natal brain in hypoxic conditions
… tumor necrosis factor-a (TNF-a), interleukin-1ß (IL-1ß), monocyte chemoattractant protein-1 (MCP-1), chemokine (C-C motif) receptor 2 (CCR2), and macrophage-colony stimulating factor (M-CSF) expression was observed. Immunoexpression of these was specifically located in AMC from 24h-7d. …
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Die Rolle des neutrophilen Granulocyten innerhalb des Immunsystems charakterisiert anhand seiner Cytokinproduktion
… the leukocytes in peripheral blood are neutrophils (PMN), which are the first cells to migrate into infected tissue. They provide innate immunity through phagocytosis of invading pathogenes.For a long time, the role of PMN in the immune system has been regarded as mere phagocytes, however recent …
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Understanding protease-mediated host-pathogen interactions in <i style="">Proteus mirabilis</i>
… metalloprotease secreted by <i>Proteus mirabilis</i>, a Gram-negative opportunistic pathogen that is primarily implicated in catheter-associated urinary tract infections (CAUTIs), which account for 80 % of all nosocomial infections. ZapA is an important virulence factor that contributes to …
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Biomarker Response After an Acute Running Bout in Participants with and without an Acute Knee Injury History
… two-group pre-test/post-test study design was utilized. The exercise bout consisted of running at 2.2 m * s -1 for 30 min on a motorized treadmill. Statistical significance was defined as p ≤ 0.05. The serum biomarker concentrations (i.e., COMP, IL-1ß, MMP-13, CTX-II, CPII, and CTX-II/CPII ratio) …
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Untersuchungen zur Expression und Regulation von Interleukin-6 und Vascular- Endothelial- Growth- Faktor ( VEGF ) im humanen Endometrium
… sowie durch Analyse des Uterussekretes. IL-6, ein gut bekanntes Phospho-Glykoprotein, wird im endometrialen Gewebe sowohl von Epithel- als auch von Stromzellen produziert. IL-6 erfüllt im menschlichen Organismus vielfältige Funktionen. Eine entscheidende Rolle scheint ihm bei Entstehung …
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The equine metabolic syndrome: studies on the pathophysiology of obesity, insulin resistance, and laminitis in equids
… inflammatory gene expression and leukocyte infiltration in several AT depots of insulin-resistant (IR) and insulin-sensitive (IS) horses. No differences in expression of TNF-a, IL-1ß, IL-6, PAI-1, or MCP-1 were noted between IR and IS groups for each depot. However, when data from IR and IS …
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Borrelienneuropathie - eine histologische und immunhistochemische Charakterisierung
… Nekrose-Faktor-alpha (TNF-alpha), Interleukin-1ß (IL-1ß) und Interleukin-6 (IL-6), als auch Metalloproteinase MMP-9 durchgeführt, ferner mit Antikörpern gegen das membranassoziierte Glykoprotein HLA-DR3. Zusätzlich wurden Semi-Dünn-Schnitte angefertigt. Klinisch wiesen die meisten BN Patienten …
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Flavonoid Intake and Periodontal Healing Outcomes Following Sanative Therapy
… was hypothesized that participants with higher daily intakes of tea and flavonoids would have improved healing outcomes, designated as greater reductions in probing depth (PD) ≥ 4 mm and salivary biomarker concentration levels (C-reactive protein, interleukin 1-beta, and interleukin-6) eight weeks …
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The effects of equine plasma transfusion on markers of inflammation in healthy neonatal foals
… (interferon-gamma [IFN-γ], interleukin- 1β [IL-1 β], tumor necrosis factor-α [TNF- α], interleukin-6 [IL-6], interleukin-10 [IL-10] and interleukin-8 [IL-8], interleukin-4 [IL-4], interleukin-17 [IL-17]), and 3) changes in acute phase protein (fibrinogen [FIB] and serum amyloid A [SAA]) …
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Characterization of Regulatory Mechanisms in Mucosal Immunity by Systems Immunology
… during Helicobacter pylori and Clostridium difficile infections. Indeed, this work integrates preclinical in vivo and in vitro experimental approaches together with a bioinformatics pipeline to identify and characterize novel regulatory mechanisms and molecular targets of the mucosal immune system …
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Production of prostaglandin E2 and thromboxane A2 by rat liver macrophages and involvement of nitric oxide and cytokines in mediator pathways under inflammatory conditions
… (Tx) A2), cytokines (e.g. interleukin (IL)-1,-6, -10, tumor necrosis factor (TNF) α) and inorganic mediators like nitric oxide (NO). Macrophages-derived products play opposing roles in the development of liver fibrogenesis: IL-1β, TNFα, IL-6, transforming growth factor (TGF)-β and TxA2 …
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Interaktion von inflammatorisch aktivierten retinalen Pigmentepithelzellen mit retinaler Mikroglia und neuronalen Zellen
… beitragen. Als wesentlich beteiligt gilt hierbei die retinale Mikroglia. Zudem können auch die Zellen des retinalen Pigmentepithels (RPE) entzündlich aktiviert werden. In dieser Arbeit untersuchten wir die Wirkung von inflammatorisch aktivierten RPE-Zellen auf retinale Mikroglia …
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The role of mitochondrial DAMPs on the inflammatory response in an <i>in vitro</i> model of canine SIRS
… a large animal model such as dogs. Given the similarities between dogs and humans, and questions regarding the usefulness of rodent models in modeling human disease, we have developed a preliminary <i>in vitro</i> model system to investigate the effects of mitochondrial DAMPs (as well as other …
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The effect of RAN inhibition on human colorectal cancer cells (CRC)
… K-Ras, DLD-1 K-Ras and Pten deletion and wild type HCT-116 and DKO-3. I used qRT-PCR and western blotting to identify expression levels of various genes and signalling molecules after treatment with 0.5 mM MBZ. In addition, several assays were performed to investigate MBZ effect on …
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MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia
… disease which may lead to death and severe disability [1, 2]. There are two major types of stroke: ischemic and hemorrhagic stroke. Both are associated with disruption of blood flow to a part of the brain with rapid depletion of cellular energy and oxygen, resulting in ionic disturbances and …
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Effects of Psychological Stress on Glucocorticoid Sensitivity of Inflammatory Response to Influenza Vaccine Challenge in Healthy Military College Students
… barriers to the health and readiness of military units worldwide with reported rates of annual influenza infection as high as 45%. Vaccination to prevent infections stimulates a transient, inflammatory response, counterbalanced by the anti-inflammatory effects of increased cortisol …
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Liberación antígeno-específica de lactoferrina por los neutrófilos en pacientes atópicos
… más evidencias de la participación de los neutrófilos en los procesos alérgicos en general y en el asma en particular. Los neutrófilos son leucocitos polimorfonucleares, que juegan un papel esencial en el sistema inmune, siendo la primera línea de defensa contra las infecciones por bacterias. Su …
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CANNABINOID RECEPTOR 2 AGONIST REDUCES IMMUNE CELL MIGRATION IN NEUROINFLAMMATION VIA INHIBITION OF MATRIX METALLOPROTEINASE-9
… mediators and peripheral immune cell infiltration into the site of inflammation. Previous studies from our laboratories demonstrated that administration of cannabinoid type 2 receptor agonist attenuated disease score and improved recovery in two murine models of neuroinflammation; spinal …
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Desarrollo y encapsulación de compuestos bioactivos de origen vegetal con efectos en el sistema cardiovascular y el cáncer
… glucosa y proteínas inflamatorias como TNF-¿, IL-6, CCL2 e IL-1ß, declarando nuevamente que metabolitos del HT como HT-acetato también fue capaz de ejercer ese efecto beneficioso. Finalmente, en los ensayos en humanos lo más destacable no es la capacidad de este compuesto de reducir …