Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 198 for “"IL-1"”.
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The Association Between The Il-1 Pathway
… UV light is its most crucial risk factor, and family history of melanoma is also an important risk factor. Melanoma is an aggressive and lethal cancer in humans. There are an estimated new 132,000 melanoma cases annually worldwide, and the trend has doubled in the past 20 years. However, attempts …
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Adult articular cartilage culture system and effects of IL-1[beta]
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1996.
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IL-1 activation of NF-kB contributes to perinatal hypoxia/ischemia induced cell death
IL-1 activity has been implicated in perinatal hypoxia/ischemia (HI) brain damage without the underlying mechanisms being characterized. We used a 7-day-old rat model to elucidate the role of NF-kB in HI stimulation of IL-1 signaling. HI was induced by permanent ligation of the left carotid artery …
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Interleukin-1 (IL-1) as a potential contributor to the pathophysiology of Alzheimer's Disease
… of the pro-inflammatory cytokine interleukin-1 (IL-1) have been reported as part of the inflammatory response to injury and neurodegenerative disorders. The observation of increased IL-1 levels in the brains of patients with Alzheimer's disease (AD) triggered over two decades of research …
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THE ROLE OF IL-¿¿1 RECEPTOR-¿¿ASSOCIATED KINASE 4 IN MICROGLIAL ACTIVATION IN ALZHEIMER’S DISEASE
… of ¿¿-¿¿amyloid into plaques and neurofibrillary tangles in the brain that is accompanied by a robust immune response. Microglia, the tissue macrophages of the brain, detect and respond to deposited amyloid. Their response is coordinated by a cell surface receptor ensemble including CD36, …
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An agent-based model of the IL-1 stimulated nuclear factor-kappa B signalling pathway
… performed since its discovery in 1986, we are still not in a position to control the signalling pathway, and thus limit the effects of NF-κB within promotion of inflammatory diseases. We believe that computational modelling and simulation of the NF-κB signalling pathway will complement wet-lab …
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SCI-Induced Chronic Pain is Driven by a Central to Peripheral IL-1 Mediated Signaling Pathway
… Research has also shown that interleukin-1β (IL-1β) is released from the site of SCI within hours of injury, but there is still a significant gap in our knowledge of its role in the development of chronic SCI pain. Recent whole transcriptome RNA sequencing performed by our laboratory has shown …
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Targeting of IL-1 and IL-18 in experimental arthritis using soluble receptors - A gene thereapeutic approach.
Contains fulltext : 19574.pdf (Publisher’s version ) (Open Access)
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Purification of SIMPL Antibody and Immunofluorescence of SIMPL Sub-Cellular Localization in Response to TNFα- and IL-1
… to pathogens, cytokines such as Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) signal through the IL-1 and TNF-α receptors, respectively, which are found on various cell types. Activation of these receptors can result in the nuclear localization of NF-κB where it enables the transcription …
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The Effect of Interleukin-1 (IL-1) Concentration on Single Cell NF-kappaB Activation in a Gradient-Generating Microfluidic Device
Interleukin-1 (IL-1) is a multifunctional cytokine produced primarily by activated monocytes/macrophages and by a variety of other cell types. IL-1 plays an integral role in the immuno-inflammatory response of the body to a variety of stimuli including infection, trauma and other bodily injuries. …
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Molecular Mechanisms of Interleukin-1beta-Stimulated Regulation of Angiogenesis in Cardiac Microvascular Endothelial Cells.
… post myocardial infarction (MI). Interleukin-1β (IL-1β), a proinflammatory cytokine increased in the heart post-MI, is considered essential for angiogenesis in tumor growth and metastasis, arthritis, endometriosis, and wound healing. Matrix metalloproteinases (MMPs) are implicated in angiogenesis …
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The Effect of Adenosine on the Production of Inflammatory Mediators By Macrophages in Response to Candida Albicans
… necrosis factor alpha (TNF-α) and interleukin 1 (IL-1). Adenosine is an important physiological molecule that can modulate the function of macrophages by altering the amounts of cytokine produced. The effect of adenosine on the production of TNF-α and IL-1 by peritoneal macrophages was studied. …
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The association between interleukin-1 gene polymorphism and periodontitis in adults in Africa: A systematic review
… tissue, is a global oral health concern. While bacterial infections initiate the problem, the body's inflammatory response impacts disease progression. Interleukin-1 (IL-1), a group of molecules known as pro-inflammatory cytokines, has emerged as a critical factor in periodontitis …
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Il-1Α Blockade Reduces Immune Suppression In The Early Tumor Micro-Environment
<p>IL-1α Blockade Reduces Immune Suppression in the Early Tumor Micro-Environment</p> <p>Brenda Melendez, B.S.</p> <p>Advisory Professor: Gregory Lizee, PhD.</p> <p>Immunotherapy against melanoma has shown great promise in the clinic for treating advanced-stage patients. However, a major barrier …
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Macrophage Response to Interleukin-1 Stimulation and the Nature of Cell Surface Interleukin-1 Alpha
Interleukin-1α (IL-1α) is a potent cytokine involved in a range of diseases and can be found expressed on the cell surface (csIL-1α) and in the soluble form, signalling through the type I IL-1 receptor (IL-1R1). IL-1 signalling leads to increased secretion of cytokines, recruitment of immune cells …
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Prevalence of interleukin-1 polymorphisms and its association with periodontal disease status in the Xhosa population of South Africa
… factors for periodontitis. A specific pattern of IL-1 polymorphisms (known as the composite IL-1 genotype) has been found to influence the severity of chronic periodontitis. The objective of this study was to evaluate the association between the IL-1 gene polymorphisms and the severity of …
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Bedeutung von DNS-Polymorphismen bei Arthrose
… im Arthrose-Prozess eine große Bedeutung haben: Il-1 alpha, Il-1 beta, TNF alpha und MMP-3 (Stromelysin). Viele bereits durchgeführte Studien lieferten widersprüchliche Ergebnisse, wiesen zu geringe Fallzahlen auf oder definierten die Kollektive nur unzureichend. Ziel dieser Studie war es klar …
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Recombinant Equine Interleukin-1 Induced Models of Equine Joint Disease
Osteoarthritis (OA) is a debilitating disease of joints that afflicts horses of all ages and breeds and can result in lameness, suboptimal performance, and decreased quality of life. The pro-inflammatory cytokine interleukin-1 (IL-1) has been associated with the initiation and pathogenesis of joint …
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An Investigation into the Effects of Macrophage Polarisation on Interleukin-1 Expression
… heterogeneity and plasticity. The prevailing dogma divides macrophages into two opposing subtypes: the pro-inflammatory M1 and anti-inflammatory M2 macrophages. Macrophages are also the main cell type that produces two powerful cytokines that drive chronic inflammation and adaptive …
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