Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"IL 1[beta]"”.
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Adult articular cartilage culture system and effects of IL-1[beta]
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1996.
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Anti-Inflammatory Effect of Adipose-Derived Mesenchymal Stem Cells for Flexor Tendon Healing
… remain prone to poor clinical outcomes. While previous attempts to improve flexor tendon healing have focused on the later stages of healing: i.e., proliferation and matrix synthesis), the early inflammatory phase of tendon healing remains poorly understood and its modulation during healing …
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Inhibition des nukleären Transkriptionsfaktors kappa B (NF-Kappa B) durch die kurzkettige Fettsäure Butyrat
… proinflammatorisch wirkender Genprodukte beteiligt. Durch Mediatoren wie TNF alpha oder IL-1 beta wird eine nukleäre Translokation von normalerweise im Zytoplasma an inhibitorische I kappa B-Proteine gebundenem NF-kappa B hervorgerufen. Im Rahmen der CU ist NF-kappa B u. a. in Lamina …
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Bedeutung von DNS-Polymorphismen bei Arthrose
… im Arthrose-Prozess eine große Bedeutung haben: Il-1 alpha, Il-1 beta, TNF alpha und MMP-3 (Stromelysin). Viele bereits durchgeführte Studien lieferten widersprüchliche Ergebnisse, wiesen zu geringe Fallzahlen auf oder definierten die Kollektive nur unzureichend. Ziel dieser Studie war es klar …
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Long-term effects of LPS and high-fat diet on dopaminergic neurodegeneration
… In the current study, it is hypothesized that IL-1 beta, a potent proinflammatory cytokine synthesized and released by glia cells, could be mediating the LPS-induced dopaminergic neurodegeneration and that the chronic low-grade inflammatory state caused by diet-induced obesity would exacerbate …
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Long-term effects of LPS and high-fat diet on dopaminergic neurodegeneration
… In the current study, it is hypothesized that IL-1 beta, a potent proinflammatory cytokine synthesized and released by glia cells, could be mediating the LPS-induced dopaminergic neurodegeneration and that the chronic low-grade inflammatory state caused by diet-induced obesity would exacerbate …
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Rodent inflammasome activation by Toxoplasma gondii
… chronic infection relies on the parasite's ability to find a balance between activation of a host immune response and evasion of parasiticidal mechanisms. This balance is achieved through the modulation of host cell processes by parasite proteins secreted from specialized secretory organelles …
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Charakterisierung von IL-4 Knockout-Mäusen und ihrer Zytokin- und Opioidrezeptor-Expression im peripheren und zentralen Nervensystem
… des antiinflammatorischen Zytokins Interleukin(IL)-4 am Tiermodell einer experimentellen Mononeuropathie (engl. chronic constriction injury, CCI) untersucht. Zentrale Fragestellung der Studie war, ob IL-4 knockout(ko)-Mäuse im Vergleich zu Wildtyp(wt)-Mäusen mit einem gesteigerten …
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A quantitative proteomics study of the additive effect of inflammatory cytokines and injurious compression on cartilage damage
… released to media on combination with cytokine (IL-1[beta[ or TNF-[alpha]) and Injury as compared to either treatment alone, and to thus identify proteins which may be responsible for the synergism seen between cytokine and injury in causing catabolism of cartilage in vitro. 2) To identify …
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The role of inflammasomes in a murine model of acute respiratory distress syndrome (ARDS)
… pulmonary inflammation that can cause organ failure which is commonly caused by sepsis, severe pneumonia and trauma. ARDS has become one of the top research priorities since the SARS-CoV-2 outbreak in 2020. From injury to damaged tissue repair, cell proliferation is a mandatory mechanistic …
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Development of a novel in vitro model to study the tryptic : endothelial cells, monocytes and flow
… the endothelial dysfunctional state. We built and integrated our in vitro model to a unique flow apparatus that can precisely replicate atheroprone and atheroprotective shear stress waveforms. We carefully characterized the model that relies on a fibronectin-coated collagenous matrix seeded …
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Autophagy and Inflammation During Rickettsial Infection
… of several proinflammatory cytokines including IL-1α, IL-6 and TNF-α and the inflammasome-dependent IL-1β when infected with rickettsiae, suggesting that autophagy suppresses the induction of these inflammatory cytokines. To investigate the regulation of autophagy induced by rickettsiae, I …
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Multidrug resistance proteins (MRP) transport the cytokine/nuclear protein High Mobility Group Box 1 (HMGB1) across membranes
High mobility group box 1 (HMGB1) is a mobile chromatin protein that can relocate into the external environment and act as a cytokine. HMGB1 cellular release can be passive, by cell necrosis, or active, by living cells after a specific stimulus is received. HMGB1 does not possess a leader sequence, …
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Regulation of proto-oncogenes and immune system genes during CSF-1-induced macrophage differentiation
… both antigen presenting and tumoricidal capabilities. In order to understand the molecular origin of macrophage diversity transcriptional and post-transcriptional regulation of genes involved in affector and effector functions were studied. Transcripts of c-fms and c-fos were detected at all …
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Fibroblasts: Key Cells in Inflammation and Fibrosis
… dissections and abdominal aortic aneurysm (AAA). IL-6 is a pro-inflammatory cytokine that is secreted by fibroblasts and macrophages in the aortic adventitia and promotes the development of aortic dissections. In our previous work, analysis of aortic adventitial fibroblast secretions in vitro …
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Protective effect of TM-25659, known as TAZ activator, on high-fat diet-induced insulin resistance in C57BL/6J mice
… Animal experiments 14 8. FGF21 secretion 15 9. IL-1β assay 15 10. Statistical analysis 15 Ⅲ. RESULTS 16 A. TM-25659 restored PA-induced insulin resistance and inflammation in skeletal muscle cells 17 B. TM-25659 increased FGF21 levels by GCN2 pathways in skeletal muscle cells 22 C. Effects …
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Extracullular Atp Regulates Il-1beta Release From Microglial Cells Via Purinergic Receptor After In Vitro Trauma
… Current literature suggests that interleukin-1Beta is an important cytokine mediator, which is dramatically increased after brain injury. Previous studies indicate that ATP is released by traumatically injured astrocytes and serves as a cell-to-cell mediator through purinergic receptors after …
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The A2A adenosine receptor: its role in suppressing vascular inflammation and its regulation by phosphorylation
… of the pro-inflammatory cytokines TNF-alpha, IL-6, IL-1 beta and GMCSF compared to wild-type mice. Consistent with this finding, heightened activation of the NF kappa B and JAK/STAT pathways was detected in aortic protein samples from A2AAR-deficient mice as demonstrated by increased levels of …
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Maternal Immune Markers In Serum During Late Gestation and In Breast Milk and the Risk of Asthma-Like Symptoms At Ages 6 and 12 Months: A Longitudinal Study
<p>Background: The role of breast milk components on childhood asthma is controversial. The aims of this prospective study are to determine the relationship of immune markers in maternal serum during gestation and breast milk to asthma-like symptoms (AS) in infancy, and the association between …
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