Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"IKK2"”.
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Die Rolle des IKK/NF-kappaB Signalweges bei der Myelinisierung, De- und Remyelinisierung des zentralen Nervensystems
… NF-kappaB Signalweges via IkappaB Kinase 2 (IKK2) auf die Cuprizon-induzierte Oligodendrozytenschädigung identifiziert werden: Die Inhibition des NF-kappaB Signalweges durch eine ZNS-spezifische IKK2-Deletion wirkt sich in diesem Modell protektiv auf Oligodendrozyten aus. Bemerkenswerterweise …
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Funktion von NF-kappa B für die Differenzierung lymphoider Zellen und die inflammatorische Aktivierung von Endothelzellen
… I kappa B-Proteine sowie die kinase-inaktive IKK2 waren in der Lage,die TNF-alpha-induzierte Ex-pression aller untersuchten Chemokine und Adhäsionsmoleküle komplett zu hem-men.Dagegen wurde durch die kinase-inaktive IKK1 nur ein Teil der untersuchten Moleküle in ihrer Expression …
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Role of the IKK complex during liver regeneration
… (composed by two catalytic subunits IKK1 and IKK2 and a regulatory subunit Nemo) tightly regulates NF-kB activity. In the present work, we modulated NF-kB activity in the liver by using hepatocyte-specific IKK2 (IKK2dhepa) and hepatocyte-specific Nemo (Nemodhepa) knockout mice and analyzed the …
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Regulatory Mechanisms in Innate Immunity
… I presented evidence that the kinase IKK2 phosphorylates IRF5 on Serine 445, leading to its dimerization and nuclear translocation. cGAMP is the first cyclic di-nucleotide discovered in metazoan. It is produced by the cytosolic DNA sensor cGAS in response to pathogen or self DNA as a …
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Signaling By Protease-Activated Receptors in Gastrointestinal Smooth Muscle
… augmented by the inhibitors of PKA (PKI), IKK2 (IKKIV), or NF-κB (MG132), and in cells expressing dominant negative mutants of IKK (IKK(K44A), IκBα (IκBα (S32A/S36A)), or phosphorylation-deficient RhoA (RhoA(S188A)). In addition, activation of PARl induced Gα12 phosphorylation, which was …