Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"IKKβ"”.
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The Role of IKKβ in Osteoclastogenesis and Inflammatory Osteolysis
… of two catalytically active subunits, IKKα and IKKβ, and one regulatory subunit, NEMO, is the main stimulator of NF-κB downstream of RANK in osteoclast progenitors. Our lab and others show that this activation is critical for stimulation of NF-κB and osteoclastogenesis. We sought to further …
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Role of the IKKβ/NF-κB pathway in alcoholism
… kappa-B kinase (IKK) complex, composed of IKKα, IKKβ, and IKKγ represents a point of convergence for many extracellular signals and regulates the NF-κB canonical pathway by targeting the inhibitor of NF-κB (IκB) for degradation. NF-κB is disinhibited, translocates to the nucleus, and acts as a …
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Role of I Kappa B Kinase Alpha and I Kappa B Kinase Beta in the Development and Function of B and T Lymphocytes
… subunits, IκB kinase α (IKKα) and IκB kinase β (IKKβ), and a regulatory subunit, IκB kinase γ (IKKγ) or NEMO. To evaluate the functions of IKKα and IKKβ in the development and function of the immune system, transgenic mice expressing dominant negative forms of IKKα and IKKβ specifically in their …
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Interrogating novel functions of the I kappa B kinases via CRISPR-Cas9 gene editing and small molecule inhibition
… is composed of two catalytic subunits (IKKα and IKKβ) and one regulatory subunit (IKKγ/NEMO) acts as the master regulator of NF-κB transcription factor activity. Seminal genetic studies in knockout (KO) mouse embryonic fibroblasts (MEFs) have defined two pathways of NF-κB activation; a canonical …
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The evaluation of targeted radionuclide therapies and radio sensitising agents in malignant melanoma
… vector. • To screen novel DNA repair and IKKβ Inhibitors in combination with X-Ray radiation to determine suitability for future targeted radiotherapy/drug combination therapy approaches. Results: [131I]MIP1145 demonstrated accumulation and retention accompanied by considerable reductions …
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Ο ρόλος του επιθηλιακού πυρηνικού παράγοντα -κΒ στη χημική και γενετική καρκινογένεση πνεύμονα
… πως η IKKα είναι πιο σημαντική ακόμη και από την IKKβ για την ανάπτυξη αδενοκαρκινώματος. Τέλος δείχνουμε πως η θεραπευτική στόχευση της IKKα με χρήση δυαδικού αναστολέα IKK παρέχει υψηλότερου βαθμού προστασία έναντι της ανάπτυξης KRAS-μεταλλαγμένου αδενοκαρκινώματος πνεύμονα σε σύγκριση με ειδικό …
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Disrupting the inhibitory Kappa B kinase (IKK) - Aurora A axis in cancer
… of three sub-units; catalytic subunits IKKα and IKKβ and the catalytically inactive scaffolding protein IKKγ/NF-κB Essential Modulator (NEMO). The complex can be assembled in multiple conformations as either hetero- or homo-dimers of IKKα/β with or without the scaffolding protein IKKγ. This …
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The Roles of Free Fatty Acids and Inflammation in β-Cell Dysfunction
… first study showed the proinflammatory kinase IKKβ is causally involved in fat-induced β-cell dysfunction during hyperglycemic clamps in vivo, ex vivo in isolated islets of fat-infused rodents and in vitro in oleate-exposed islets. This is the first study to show directly that β-cell IKKβ plays …
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Investigation onto the Mechanism Behind the Hepatoprotective Effect of Cucurbitacin Compounds
… and virtual cucurbitacin analogs over NF-kB, and IKKβ crystal structures was conducted. Docking data revealed approximately 100 potential cucurbitacin analogs with higher binding affinity to the hydrophobic pocket of NF-kB and IKKβ compared to standard IKK inhibitor (PS-1145). Cucs B, D, and iso-D …
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MITOCHONDRIA FACILITATE VASCULAR INFLAMMATION: THE ROLE OF CANONICAL INFLAMMATORY SIGNALING IN THE REGULATION OF MITOCHONDRIAL MORPHOLOGY
… mediates mitochondrial fission through an IKKβ/IκBα-dependent pathway. IκBα is found to localize on the mitochondrial outer membrane where it inhibits DRP1 recruitment to the mitochondria. Inhibition of this cascade promotes elongated mitochondria that are unable to go through fission. …
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Characterization of novel immunomodulatory proteins encoded by parapoxvirus ORF virus
… of IκB kinase (IKK) subunits IKKα and IKKβ, IκBα and NF-κB subunit p65 (NF-κB-p65), and to early nuclear translocation of NF-κB-p65 in virus-infected cells (≤ 30 min post infection). Consistent with observed inhibition of IKK complex activation, ORFV073 interacted with the regulatory …
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An investigation of the activation of protein kinase complexes in the MyD88 signalling network
… and IRF5 and the protein kinase Tpl2, but how IKKβ itself is activated in vivo is still unclear. It was found to require phosphorylation by one or more ‘upstream’ protein kinases in some reports, but by autophosphorylation in others. In the first part of this thesis, I describe my work that has …
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The Association Between The Il-1 Pathway
… ECSIT, TRAF6, TAB1, TAK1, RKIP, NIK, IKKα, IKKβ, IκBα, and NF-κB.</p> <p>The individual SNP analysis proved to be interesting though inconclusive. There were some borderline significant results, such as associations of the SNPs rs16944, rs1143627, rs1071676, and rs3136558 with the endpoint …