Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"IKK"”.
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BIOCHEMICAL CHARACTERIZATION OF SUPPRESSOR OF IKK-ε AND NAK-ASSOCIATED PROTEIN 1
<p>Innate immunity provides the first line of defense against invading pathogen by recognizing and mounting a response to the pathogenic challenge. Among the cellular mechanisms of the innate immune response, Toll-like receptor 3 (TLR3) recognizes viral dsRNA and signals subsequent production of …
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Disrupting the inhibitory Kappa B kinase (IKK) - Aurora A axis in cancer
The IKK complex is an essential regulator of the NF-κB signalling pathway. It is comprised of three sub-units; catalytic subunits IKKα and IKKβ and the catalytically inactive scaffolding protein IKKγ/NF-κB Essential Modulator (NEMO). The complex can be assembled in multiple conformations as either …
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Synthesis of inhibitors of the IKK-complex for the treatment of prostate cancer
This thesis was previously held under moratorium from 24 July 2012 until 24th July 2016.
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The Role of Traf6 Phosphorylation In Src/Traf6-Mediated Ikk, Jnk, Akt Activation and Tumorigenesis
… Upon activation, it mediates activation of IKK/NF-κB and JNK signaling in response to engagement of toll-like receptor 4 (TLR4), interleukin-1 receptor (IL-1R), and receptor activator of NF-κB (RANK) to their cognate ligands, including lipopolysaccharide (LPS), IL-1, and RANK ligand (RANKL). …
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Die Rolle des IKK/NF-kappaB Signalweges bei der Myelinisierung, De- und Remyelinisierung des zentralen Nervensystems
… NF-kappaB Signalweges via IkappaB Kinase 2 (IKK2) auf die Cuprizon-induzierte Oligodendrozytenschädigung identifiziert werden: Die Inhibition des NF-kappaB Signalweges durch eine ZNS-spezifische IKK2-Deletion wirkt sich in diesem Modell protektiv auf Oligodendrozyten aus. Bemerkenswerterweise …
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Evaluation of therapeutic effect of IKK epsilon SiRNA on breast cancer cells and development of a peptide-based SiRNA delivery system
… 3, we examined the therapeutic potential of IKKε siRNA on human breast cancer cells. Eight siRNAs targeting different regions of the IKKε mRNA were designed, and the silencing effect was screened by quantitative real time RT-PCR. Silencing of IKKε in human breast cancer cells resulted in …
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Host cell signaling in response to RSV infection
… that RIG-I was involved in the activation of NIK/IKK alpha complex, two key noncanonical kinases that induce the protelytic processing of an I kappa B alpha-like inhibitor p100 to p52. I also proved that a fraction of RelA was associated with cytoplasmic p100. In addition, the RSV-induced …
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Biochemical Mechanism of Protein Kinase Activation by the Ubiquitination System
… NF-κB is activated through activation of TAK1-IKK cascade by TRAF6 and Ubc13/Uev1A in a polyubiquitinationdependent manner. Mechanistically how TAK1 is activated by the TRAF6- Ubc13/Uev1A dependent polyubiquitination system is unknown. Whether TAK1 and IKK kinases can be activated by other than …
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Characterization of the Anti-Inflammatory Effects of the Molluscum Contagiosum Virus MC160 Protein
… both procaspase-8 and Hsp90 associate with the IKK complex, we believe that the MC160 protein binds these proteins as a means to destabilize the IKK complex, resulting in reduced IKK activation, and ultimately, inhibition of NF-kappaB activation.
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Inhibition of Heat Shock Protein 90 Reduces Inflammatory Signal Transduction in Murine J774 Macrophage Cells and Lessens Disease in Autoimmune MRL/lpr Mice: What in vitro, in vivo, and in silico Models Reveal
… cellular response of inhibitor of κB kinase (IKK) activation and NF-κB activation to LPS stimulation. Model parameters were fit to IKK activation data. Parameter sensitivity was assessed through simulation studies and showed a strong dependence on IKK-HSP90 binding. The model also accounts for …
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Liquid-Liquid Phase Separations in Innate Immune DNA Sensing and NF-κB Signaling Pathways
… is essential for the activation of IκB kinase (IKK) complex in NF-κB signaling, including Interleukin-1 (IL-1β), Tumor Necrosis Factor (TNFα) and Toll-like receptors (TLR) pathways. NEMO activates IKK complex by binding to polyubiquitin chains. Here we show that Lys63(K63)-linked or …
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Studies on the mechanism of insulin signaling reduction in high glucose/palmitate-induced INS-1 beta cell death
… 를 감소 5 3. PTPs에 의해서 IRS-1 tyrosine 인산화가 감소 7 D. IKK 10 E. 연구 목적 13 Ⅱ. 재료 및 방법 (혹은 연구대상 및 방법) 14 A. 재료 14 1. 재료 14 B. 방법 16 1. 세포주 및 세포주 배양 16 2. MTT assay 16 3. Western blotting 16 4. Transfection 17 Ⅲ. 결과 19 A. INS-1 베타세포에서 고농도 포도당과 palmitate에 의한 세포사 19 1. HG/PA에 의한 INS-1 베타세포 사멸 19 2. HG/PA에 의한 …
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Ubiquitin Mediated Regulation of NF-kappa B Signaling
… of TAK1, which leads to the activation of IKK. Activation of IKK leads to K48-linked ubiquitination, and the subsequent proteasomal degradation of IκBalpha . Two important areas of research focusing on ubiquitin regulation of NF-κB signaling are addressed in this dissertation. The areas …
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Biochemical and Genetic Studies on CC2D1A, a new NF-κB Activator and a Regulator of Synaptic Functions
… for NF-κB activation. CC2D1A activates the IKK complex and NF-κB target genes through several key components in the canonical pathway including ubiquitin-conjugating enzyme UBC13, a RING domain ubiquitin ligase TRAF2, a protein kinase TAK1, and an essential regulator of IKK complex, NEMO. …
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Interrogating novel functions of the I kappa B kinases via CRISPR-Cas9 gene editing and small molecule inhibition
… to inflammatory cytokines. The IκB kinase (IKK) complex, which is composed of two catalytic subunits (IKKα and IKKβ) and one regulatory subunit (IKKγ/NEMO) acts as the master regulator of NF-κB transcription factor activity. Seminal genetic studies in knockout (KO) mouse embryonic …
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Role of the IKKβ/NF-κB pathway in alcoholism
… genes. The inhibitory kappa-B kinase (IKK) complex, composed of IKKα, IKKβ, and IKKγ represents a point of convergence for many extracellular signals and regulates the NF-κB canonical pathway by targeting the inhibitor of NF-κB (IκB) for degradation. NF-κB is disinhibited, translocates …
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Notch-1 Activates Nf-Кb Activity in Cervical Cancer and Estrogen Receptor Negative Breast Cancer
… activates NF-КB activity by interacting with IKKα/β and regulating IKKα/β kinase activity in CaSki cells stimulated with TNF-α.</p><p>Lastly, we demonstrated that Notch-1 activates NF-КB dependent gene expression in MDA-MB-231 cells through an Akt/IKK dependent pathway. We showed that …
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An investigation of the activation of protein kinase complexes in the MyD88 signalling network
The TAK1 and canonical IKK complexes are the two master protein kinases of the innate immune system that control the production of inflammatory mediators, but the mechanisms by which they are activated in this system are still unclear. In this thesis, I present the research I have carried out to …
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The Role of Dual Specificity Phosphatase -11 In Innate and Adaptive Immune Responses
… the gamma binding domain (gbd) of IKK-b and thus positively regulates the activity of the IKK complex. Together, we demonstrate for the first time that DUSP11 is a critical regulator of immune responses and acts specifically by mediating IKK activation during innate immune …
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