Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"IHH"”.
-
Ihh Signaling and Muscle Forces are Required for Enthesis Development
… a murine reporter of active Indian hedgehog (Ihh) signaling, we identified a population of cells present early in development that populate the mature enthesis. Lineage tracing analyses indicated that this cell population remained at the mature enthesis while down-regulating Ihh signaling in …
-
Lineage specification of ovarian theca cells requires multi-cellular interactions via oocyte and granulosa cells
… Desert hedgehog (Dhh) and Indian hedgehog (Ihh) from granulosa cells. Ovaries lacking Dhh/Ihh exhibited a loss of theca layer, blunted steroid production, arrested folliculogenesis, and failure to form corpora lutea. Production of Dhh/Ihh in granulosa cells requires growth differentiation …
-
Asociación de la fragmentación en la atención en salud y la supervivencia global de mujeres con cáncer de cuello uterino afiliadas al régimen contributivo en Colombia
… de prestadores y el índice Herfindahl-Hirschman (IHH) para medir la fragmentación durante el primer año de atención. La SG a cinco años se analizó con estimaciones de Kaplan-Meier y modelos de regresión de Cox. Resultados La mediana de prestadores durante el primer año fue de 6 (RIC 4-8) y del IHH …
-
Investigation of the E3 ubiquitin ligase UBR5; a novel regulator of Hh gene expression
… phenotype, however quantitative analysis of Ihh gene expression and its downstream targets at E13.5 demonstrated a significant decrease in levels. In addition, changes in the expression of Runx2 and Msx2 were detected. Therefore, these data indicate that UBR5 can act as a positive regulator …
-
Development and characterisation of a novel chimeric antigen receptor against LGR5
… I used knockout mouse models of the Hh ligand Ihh and Hh transcription factor Gli1 in a series of in vitro cytokine polarisation assays, in vivo homeostatic proliferation models and antigen-driven memory formation and rechallenge influenza A virus infection models. Across all systems tested, …
-
Caractérisation des mécanismes inhibiteurs de la voie de signalisation Hedgehog dans les cancers du côlon
… côlon malgré la présence des ligands de la voie IHH et SHH dans certaines lignées. Au cours de ce travail, les expressions des membres inhibiteurs de la voie de signalisation Hedgehog, HIP (Hedgehog interacting protein), SuFu (Suppressor of Fused) et ZIC 2, ont été étudiées dans les cancers du …
-
TARGETING THE DNA DAMAGE RESPONSE PATHWAY FOR THE TREATMENT OF AGGRESSIVE THYROID CANCERS, IN VITRO STUDIES
… cell line proved fully LENV sensitive, while IHH- 4, characterized by alterations in p300/CBP complex regulating p53 function, showed low sensitivity to LENV, and FRO, lacking p53 expression, displayed resistance to LENV. Therefore, we sought to further investigate in vitro the DNA damage …
-
Definición del mercado relevante de distribución minorista de combustibles líquidos : una aproximación al análisis de competencia para Colombia
… del cálculo del índice de Herfindahl–Hirschman (IHH). Los resultados revelan altos niveles de concentración en la mayoría de los mercados: en el caso del diésel, el 99% de los mercados definidos se clasifican como altamente concentrados, y el 1% como moderadamente concentrados, sin registrarse …
-
Dissecting the Role of Hedgehog Signaling in Tumor-associated Macrophages and Immunosuppression in the Tumor Microenvironment
… desert hedgehog (Dhh) and indian hedgehog (Ihh) can also be secreted from tumor cells to modify the TME in order to create a more favorable environment to foster tumorigenesis. However, little is known about how Hh ligands change the TME to promote tumor progression and what cell type(s) are …
-
Molecular mechanisms regulating implantation
… Inhibitory Factor (LIF) and Indian Hedgehog (IHH). The second part of this study investigates the role of signal transducer and activator of transcription 3 (STAT3) in the uterine epithelial cells during implantation. STAT3 is activated downstream of LIF, an E target gene, in the uterine …