Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 148 for “"IHC"”.
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The suitability of the South African corporate tax regime for the use of South African resident intermediary holding companies
An Intermediary Holding Company (“IHC”) is a company that is interposed between an ultimate holding company and the operating subsidiaries of a group of companies. The IHC operates at an international level such that either its holding company or its subsidiaries or both are located in a country …
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Inertial Hysteresis Couplings
… presents the Inertial Hysteresis Coupling (IHC), a new family of variable-slip mechanical couplings/clutches aimed at achieving order-of-magnitude (∼10x) improvements in torque density (torque capacity / coupling diameter) over existing magnetic and fluid options. IHCs leverage combined …
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Plasma velocities in the Heliosheath and the influence of the interstellar wind
… (Interstellar Heliospheric Coordinates, or IHC) is introduced to enable the detailed study of the influence of the interstellar wind on the heliosheath. Recent, in situ measurements of plasma velocities in the heliosheath by Voyager 2 are projected into the IHC system and analyzed. We …
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Tumour Localisation in Histopathology Images
Immunohistochemical (IHC) assessment in cancer research is important for understanding the distribution and localisation of biomarkers at the cellular level. However currently IHC analyses are predominantly performed manually, increasing workloads and introducing inter- and intra-observer …
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Application of radioisotope imaging and therapy in patients with breast carcinomas that express the sodium iodide symporter gene
… detectable NIS protein by immunohistochemistry(IHC). Experimental design Tumour samples from patients with breast cancer were analysed by immunohistochemistry and ribonucleic acid(RNA) analysis, and this was correlated with functional activity of the NIS protein, by scintigraphic scanning of …
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Feline Leukemia Virus Detection in Corneal Tissues of Cats by Polymerase Chain Reaction and Immunohistochemistry
… chain reaction (PCR) and immunohistochemical (IHC) testing, respectively. Eleven (64.7%) positive corneal PCR results were obtained from 17 ELISA positive cats. Of 12 cats which were both ELISA and IFA positive on peripheral blood, 10 (83.3%) had positive corneal PCR results. All corneal …
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Prognostic factors in soft tissue sarcoma. Tissue microarray for immunostaining, the importance of whole-tumor sections and time-dependence.
… and the prognostic value of immunohistochemical (IHC) expression of biological markers is unclear. The tissue-preserving, high throughput tissue microarray (TMA) technique for analysis of immunohistochemical expression of biological markers was validated for Ki-67, and was found to yield results …
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Mutation of SLC7A14 Causes Syndromic Hearing Loss
… is upregulated in adult mouse inner hair cells (IHCs) compared to outer hair cells (OHCs). Mutations in this gene are associated with autosomal recessive retinitis pigmentosa (RP) in humans. SLC7A14, a glycosylated transporter protein with 14 transmembrane domains, is predicted to mediate …
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A novel approach to the clinical diagnosis and treatment of canine histiocytic sarcoma
… on diagnosis including immunohistochemistry (IHC), the use of a combination treatment protocol in cell culture, and potential use of serum biomarkers in monitoring response to treatment. The use of different IHC markers on formalin fixed tissue samples were evaluated in their ability to …
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A study of the use of immunohistochemical stains in an academic hospital
… is focused on the use of immunohistochemical (IHC) stains in the pathology department. This paper covers the possible effects of the ACA on laboratory operations, an overview of pathology, and the use of IHC by subspecialty. It will concludes with results of the findings and how they can be …
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Deep Learning in Oesophageal Cancer Development: Integrating Multi-Stain Histopathology Images of the Capsule Sponge
… regions dominate, and immunohistochemistry (IHC) slides contain control tissue that complicates automated analysis. This thesis develops and evaluates a computational pipeline to address these challenges and enable scalable risk stratification for BE. First, I present non-AI based …
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Investigating the relationship between lung cancer and the infection with the parasite Toxoplasma gondii
… by nested PCR and immunohistochemistry (IHC), and it documented a striking 100% prevalence. We recruited ten lung samples via bronchoalveolar lavage from healthy individuals to be used as a control group for the lung cancer patients study. Samples were tested with nested PCR targeting …
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An Investigation into the Vascular Phenotypes of Breast Patient- Derived Xenografts
… displayed different vascular features on ex vivo IHC, which PAI was sensitive to in vivo. Overall, the PDXs were robust and reliable vascular models, with little inter-passage variability and similarity to patient vascular phenotypes shown on IHC. Demand and supply of oxygen through the blood …
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Sublethal Hepatic Pathology and Evidence of Intranuclear Effects of the Cyanobacterial Toxin Microcystin -Lr
… characterized. MCLR immunohistochemistry (MCLR-IHC) studies indicate that the nucleus may be a target of MCLR. Balb/c mice were given one sublethal dose at 45 mug/kg or repeated daily doses for 2, 4 and 7 days. At 2 hours post-dosing there was centrilobular hepatocellular hypertrophy, glycogen …
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Development of supervised and unsupervised pixel-based classification methods for medical image segmentation
… nuclei on immunohistochemically stained (IHC) specimens as suggested by the American Society of Clinical Oncology (ASCO) protocol. Recent studies have attempted to examine whether histological tumour grade relates to ER status. Such a relation seems to be of importance in the various …
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Thermal Ablation Alters The Tumor Microenvironment Activating A Robust Immune Response.
… microarray analysis and immunohistochemistry (IHC) for presence of immune cell subtypes were performed on the tissue samples. Prospectively, blood was collected from patients 13 patients who underwent renal ablation for renal cell carcinoma for stage T1a (less than 4cm) at baseline and at day …
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Plastic Embedding Techniques for Light Microscopy Histological Studies
… procedures were initiated for the application of IHC on plastic- embedded tissue that included the development of a modified plastic with new preparatory techniques, and changes in immunocytochemical staining protocols to enable IHC to be routinely performed. Previously, this had been regarded as …
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Assessing Inter-rater Agreement for Compositional Data
… where pathologists rate immunohistochemistry (IHC) assays using compositional scores. To enhance the use of this methodology and help with the design of future agreement studies, an R Shiny package designed for the IHC agreement analysis is developed.
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Chronic Stress Promotes Tumor Growth Through Increased Bdnf Production and Neo-Innervation
… ovarian cancer models. Immunohistochemical (IHC) staining for neurofilament revealed that catecholaminergic neurons are present within tumor tissue. In order to determine whether chronic stress affects the density of nerves in the tumor, I utilized an orthotopic mouse model of ovarian cancer …
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