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Showing 1 to 12 of 12 for “"IGHV"”.

  1. Stellenwert von IGHV-Mutationsstatus, CD38-Expression und chromosomalen Aberrationen innerhalb der CLL4-Studie der Deutschen CLL-Studiengruppe (DCLLSG)

    Binder, BirgitUniversität Ulm

    ulm-diss Repository record

  2. Evaluation of TP53 and IGHV clinical molecular prognostic testing for patients with Chronic Lymphocytic Leukaemia at Tygerberg Hospital

    Nkwanyane, Tinashe NthabisengStellenbosch : Stellenbosch University2026

    … the immunoglobulin heavy chain variable region (IGHV) gene have emerged as critical molecular prognostic biomarkers with significant therapeutic implications for risk stratification and treatment selection. This study aimed to optimise, validate, and verify polymerase chain reaction (PCR)-based …

    stellenbosch Repository record

  3. Ldoc1, A Novel Biomarker of Prognosis In Chronic Lymphocytic Leukemia

    Duzkale, Hatice2012

    … the immunoglobulin heavy chain variable region (IGHV) genes. Patients whose CLL cells have unmutated IGHV genes have a median survival of 8 years; those with mutated IGHV genes have a median survival of 25 years. To identify new prognostic biomarkers and molecular targets for therapy in untreated …

    uthsc Repository record

  4. Characterisation of genetic complexity in chronic lymphocytic leukaemia

    Timbs, Adele T.Oxford Brookes University2017

    … of the immunoglobulin variable heavy-chain (IgHV) in 497 pre-treatment CLL patients found IgHV subclones in 18.5%, far higher than previously reported. SNP array analysis in 411 CLL patients refined the minimally overlapping regions (MOR) on del(6q) to the ATG5 and PRDM1 genes. Further …

    oxford-brookes Repository record

  5. Array based genetic profiling of chronic lymphocytic leukemia

    Gunnarsson, RebeqaDepartment of Laboratory Medicine, Lund University2010

    … unmutated immunoglobulin heavy chain variable (IGHV) genes and treated patients with mutated IGHV genes often gained novel aberrations. In paper III, high-density screening revealed a different spectrum of genomic aberrations in CLL patients with ‘stereotyped’ IGHV3-21 (poor-prognostic) versus …

    lund Repository record

  6. Functional role of ZAP70 in Chronic Lymphocytic Leukaemia

    Sathiaseelan, VijithaUniversity of Cambridge2020

    … There are 2 main subtypes of CLL based on the IgHV status: Un-mutated CLL (UM-CLL) and Mutated CLL (M-CLL). M-CLL leads to good prognosis whereas UM-CLL is the more aggressive form of the disease that could lead to Richter syndrome. Prognostics markers for CLL are the IgHV mutational status, …

    cambridge Repository record

  7. Novel approaches to assess cellular interactions and their role in the pathology and treatment of lymphoproliferative disorders

    Frend, Frances Hilary Rose2022

    … 1 (NOTCH1) genes, which are all more frequent in IGHV-unmutated disease. This work describes the development of techniques to characterise and quantify morphological responses to inhibitors, aiming to produce a quantitative description of cytoskeletal changes relating to specific signalling …

    plymouth Repository record

  8. A novel genomics and bioinformatics approach to assess immunoglobulin and T cell receptor rearrangements and somatic hypermutation in lymphoproliferative disorders

    McCafferty, NeilQueen's University Belfast2021

    … was found to significantly correlate with SSeq IGHV%.<br/><br/>Novel bioinformatic analysis of IGHJ-E and introduction of a stringent 99.8% mutational threshold in tested LPD cohorts found between 88.16-97.44% concordance (90.3% in all 175 samples) with SSeq SHM status. Poor SHM stratification …

    qu-belfast Repository record

  9. Molecular Insights of Primary Thyroid B-cell Lymphomas by Somatic Genetic and Immunogenetic Profiling

    Tzioni, MariaUniversity of Cambridge2024

    … found significant overrepresentation of several *IGHV* genes including *IGHV1-46*, *IGHV3-23*, *IGHV3-49*, *IGHV4-61* and *IGHV4-34* in thyroid lymphomas. A high proportion (70%) of *IGHV3-23* rearrangements in thyroid lymphoma had a CDR3 sequence with shared amino acid motifs to those of thyroid …

    cambridge Repository record

  10. Understanding the biology of CD180 in chronic lymphocytic leukemia

    Edwards, K.University of Westminster2024

    … immunoglobulin heavy chain variable genes (IGHV), a subset of patients with a superior prognosis, which confirms previous observations. We also found that higher CD180 expression in both the peripheral blood and lymph nodes was associated with superior OS in CLL. Given the growing evidence …

    westminster Repository record

  11. Humanisierung von Maus-Hybridomantikörpern

    Lüttgau, Sandra MarenUniversität Heidelberg

    … eines flankierten NPTII Gens in den aktiven IGHV Genlokus wurde bereits erfolgreich in HEA125 getestet. Die homolog rekombinierten Zielzellen konnten mittels PCR nachgewiesen werden, waren aber nicht stabil. Deshalb ist die Einführung der spezifischen Rekombinationsstellen direkt mittels …

    heid-diss Repository record

  12. Applications of next-generation technologies in the diagnosis of haematological diseases and cancer

    Burns, Adam D.Oxford Brookes University2016

    … the genome, including in patients with unmutated IgHV genes. Regions of localised hypermutation are present in CLL, with a number affecting genes associated with coding mutations in CLL, including ATM, KLHL6 and MEGF9. A number of mutation clusters are also identified in potentially regulatory …

    oxford-brookes Repository record