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Showing 1 to 20 of 31 for “"IGH"”.

  1. Role of AID and microRNA-155 in c-myc-IgH Translocations

    Dorsett, Yair

    … B cells, suggesting that these translocations might be the result of aberrant V(D)J recombination. However, in mature B cells undergoing AID dependent somatic hypermutation (SHM), duplications or deletions that would necessitate a double strand break make up 6% of all the Ig V-JH region …

    rockefeller Repository record

  2. Characterization of Loop Extrusion and Regulatory Elements in IgH Locus Structure and Function

    Ellen Brandenburg Drake (24400643)2026

    V(D)J recombination is a highly ordered and stepwise process that enables antigen receptors to detect a wide variety of antigens. The Igh locus undergoes large-scale locus contraction prior rearranging in pro B cells. A series of nested chromatin loops anchored by a series of distal VH enhancers, …

    uic

  3. Spatial organisation of the immunoglobulin heavy chain locus and inter-chromosomal gene networks driving B cell development

    Mielczarek, OlgaUniversity of Cambridge2018

    … recognize a countless number of antigens. This highly diverse repertoire is produced during B cell development in the bone marrow from the immunoglobulin heavy chain (Igh) and light chain (Igk and Igl) loci. The mouse Igh is a large (~3Mb) multigene locus that contains 195 variable (V), 10 …

    cambridge Repository record

  4. The Role of ZMYND8 in Immunoglobulin Class Switch Recombination

    Rosen, Daniel Benjamin

    … actively transcribed immunoglobulin heavy chain (Igh) switch donor and acceptor DNA. The 3' Regulatory Region (3'RR), a prototypical super-enhancer located at the 3' of the Igh locus, is essential for acceptor switch region transcription, but the mechanism by which it regulates this process is not …

    rockefeller Repository record

  5. Evidence that ARNT plays a role in the regulation of the immunoglobulin heavy chain enhancer and identification of a putative ARNT ligand

    Yavrom, Sheena2018

    … ARNT (Ah receptor nuclear translocator) at the IgH (immunoglobulin heavy chain) enhancer. We were able to determine that ARNT appears to partially down-regulate activation at the IgH enhancer by Pan-1 in transient transfection assays by cotransfection of the multimerized murine form of the IgH …

    u-pacific Repository record

  6. Multilineäre Beteiligung der Leukämogenese in der BCR::ABL1-like Akuten Lymphoblastischen Leukämie

    Amelunxen, Eric LeanderChristian-Albrechts-Universität zu Kiel

    … in 3 von 10 JAK-/STAT-Klassen-Proben. Die IGH::CRLF2-Translokation konnte exemplarisch in CD33/CD13-positiven myeloischen Kompartimenten mit einer Frequenz von 56 % nachgewiesen werden. Weiterhin zeigte eine Probe eine Beteiligung myeloischer Kompartimente mit 11 % bzw. 10 %. Zusätzlich …

    cau-kiel Repository record

  7. Vβ Recombination Signal Sequences Mediate Monoallelic And Monogenic Tcrβ Gene Assembly: Implications For The Tcrβ Repertoire And Allelic Exclusion In Health And Disease

    Wu, Glendon Shou-Shi2020

    … recombination to form a functional gene. TCRβ, IgH, and Igκ allelic exclusion is achieved by: assembly of an in-frame gene on one allele, transient inhibition of V(D)J recombination signaled by RAG DNA double stranded breaks (DSBs), and the resulting protein sending feedback signals to …

    penn Repository record

  8. The Role of Activation-Induced Cytidine Deaminase in Antibody Diversification and B Cell Malignancies

    Market, Eleonora

    … an organism as it gives rise to antibodies of high affinity and avidity crucial in clearance of the antigen by humoral immune response. Aberrant AID activity, however, can lead to c-myc/IgH chromosomal translocations and ultimately to B cell lymphomas and plasmocytomas in mice. Such …

    rockefeller Repository record

  9. HIV Specific B Cell Response in Patients With Broadly Neutralizing Serum Activity

    Scheid, Johannes F

    … Some HIV infected individuals develop high titers of broadly neutralizing IgG antibodies in their serum, but until recently very little was known about the specificity and activity of these antibodies. To characterize the broadly neutralizing memory antibody responses to HIV we cloned …

    rockefeller Repository record

  10. Investigation of the three dimensional organisation of the genome in B cell development

    Rogers, CarolynUniversity of Cambridge2021

    … multimegabase murine immunoglobulin heavy chain (Igh) and immunoglobulin kappa chain (Igκ) loci must not only facilitate recombination between gene segments separated by up to 3Mb, but diverse recombination events. To understand how this is achieved a capture Hi-C (CHi-C) approach was developed to …

    cambridge Repository record

  11. Dna Polymerase Θ (Polq) and The Cellular Defense Against Dna Damage

    Yousefzadeh, Matthew J2017

    … of base pairs at the joins with homology to <em>IgH</em> switch-region sequences. Biochemical experiments with purified human POLQ protein revealed the mechanism generating the insertions during DNA end joining, relying on the unique ability of POLQ to extend DNA from minimally paired …

    uthsc Repository record

  12. Bioinformatics pipeline development for analyses of data generated by target capture-based Next-Generation Sequencing, to characterise mutations and the utility of using off-target sequences to detect genomic imbalances in Multiple Myeloma patients.

    Coysh, AlixResearchSpace@Auckland2023

    … gene panel (CGP)/Immunoglobulin Heavy Locus (IGH) tiling array on paired germline/peripheral blood and tumour/bone marrow samples from sixMM patients (aka MM1-MM6). All quality metrics confirmed successful sequencing, genomic alignment and enrichment, corroborating sufficiency for downstream …

    auckland-ms Repository record

  13. Molecular Insights of Primary Thyroid B-cell Lymphomas by Somatic Genetic and Immunogenetic Profiling

    Tzioni, MariaUniversity of Cambridge2024

    … thyroid lymphomas, I investigated the rearranged IGH genes in a cohort of 41 thyroid lymphoma cases. I found significant overrepresentation of several *IGHV* genes including *IGHV1-46*, *IGHV3-23*, *IGHV3-49*, *IGHV4-61* and *IGHV4-34* in thyroid lymphomas. A high proportion (70%) of *IGHV3-23* …

    cambridge Repository record

  14. The Extent and Nature Of Chromosomal Rearrangements in B Lymphocytes

    Klein, Isaac Andrew

    … 400 million activated B lymphocytes to two loci, IgH and c-myc. Our data and analysis reveal that proximity between DSBs, transcriptional activity and chromosome territories are key determinants of genome rearrangement. Specifically, rearrangements tend to occur in cis and to transcribed genes. We …

    rockefeller Repository record

  15. Targeting Protein Degradation to Uncover Novel Oncoprotein Drivers of Acute Leukemia

    Keramatnia, Fatemeh2024

    … and molecular biology, ALL treatment remains highly challenging especially after relapse. Conventional chemotherapy has shown significant improvement in overall survival rates of pediatric patients up to 90%, however, treatment failure due to ALL relapse occurs in 15-20% of the cases. On the …

    tenn-hsc Repository record

  16. Investigation of Ring Finger Protein 8 in Mammalian Physiology and Pathogenesis

    Li, Li2015

    … processes such as immunoglobulin heavy chain (IgH) class switch recombination (CSR), an important mechanism for antibody diversification and specification of immunoglobulin effector function during a humoral immune response in mammals. Through catalyzing ubiquitylation of the H2A-type histones …

    toronto-retro Repository record

  17. Molecular Pathogenesis of MALT lymphoma

    Hamoudi, Rifat AUniversity of Cambridge2010

    … t(1;14)(p22;q32)/BCL10-IGH and t(14;18)(q32;q21)/IGH-MALT1, which commonly activate the NF-κB pathway. Gastric MALT lymphomas harbouring such translocation do not respond to Helicobacter pylori eradication, while those without translocation can be cured by antibiotics. To …

    cambridge Repository record

  18. Cytogenetic and Molecular Cytogenetic Markers in Patients with Multiple Myeloma - Prognostic Significance // Цитогенетични и молекулярно-цитогенетични маркери при пациенти с множествен миелом – прогностично значение

    Miteva, Valentina, Митева, ВалентинаMedical University of Varna2023

    … 5 patients with a hyperdiploid karyotype and eight patients with a non-hyperdiploid karyotype. Apart from these groups, a deletion in chromosome 16 was found in 1 patient in all metaphases. We found a statistically significant difference between those with normal and pathological karyotypes and …

    varna Repository record

  19. Etablierung einer Fluoreszenz-Multiplex-Polymerase-Ketten-Reaktion zur semiquantitativen und qualitativen Analyse des V H-Repertoires in humanen B-Lymphozyten

    Feuchtenberger, MartinUniversität Würzburg

    … zur Verfügung. In zwei Multiplex-PCRs werden IgH Produkte der sechs häufigsten VH-Familien mit familienspezifischen und fluoreszenzmarkierten Primern (FAM, HEX, NED und ROX) amplifiziert. Die Auftrennung der Produkte erfolgt durch Elektrophorese in einem ABI Prism 377 Sequencer. In …

    wurz-thes Repository record

  20. ΧΗΜΙΚΗ ΑΝΟΣΙΑ ΣΕ ΑΣΘΕΝΕΙΣ ΜΕ ΧΡΟΝΙΑ ΕΝΕΡΓΟ ΗΠΑΤΙΤΙΔΑ ΣΕ ΣΧΕΣΗ ΜΕ ΤΗΝ ΠΑΡΟΥΣΙΑ ΤΟΥ HBSAG

    Κωτσοβόλου-Σώτου, ΔανάηNational and Kapodistrian University of Athens1985

    … AUTOANTIBODIES BY INDIRECT IMMUNOFLUORESCENCE. HIGHER LEVELS OF IMMUNOGLOBULINS, SPECIALLY IGG AND IGH, WERE FOUND IN THE HBSAG NEGATIVE GROUP OF PATIENTS. INCREASED FREQUENCY OF ANTIBODIES TO RUBELLA WAS OBSERVED IN ALL PATIENTS OF BOTH GROUPS BUT THERE WAS NO DIFFERENCE BETWEEN THEM. HIGHER …

    greece Repository record

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