Global ETD Search
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Showing 1 to 9 of 9 for “"IGFBP2"”.
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Igfbp2 Potentiates Egfr-Stat3 Signaling In Glioma
… Insulin-like growth factor binding protein 2 (IGFBP2) is a pleiotropic oncogenic protein that has both extracellular and intracellular functions. Despite a clear causal role in cancer development, the contributions of intracellular IGFBP2 to tumor development and progression are poorly …
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Elucidating The Igfbp2 Signaling Pathway In Glioma Development and Progression
… modalities currently available to treat them. IGFBP2 is a newly recognized oncogene that is operative in multiple cancer types, including glioma, and shows promise for a targeted therapeutic approach. Elevated IGFBP2 expression is present in high-grade glioma and correlates with poor survival. …
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Insulin-Like Growth Factor-Binding Protein 2 Supports Hematopoietic Stem Cell Expansion: From In Vitro to In Vivo
… insulin-like growth factor binding protein 2 (IGFBP2), secreted by a tumorigenic cell line, also enhanced ex vivo expansion of mouse HSCs. As measured by competitive repopulation analyses, there was a 48-fold increase in numbers of long-term repopulating mouse HSCs after 21 days of culture. …
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Micrornas in Breast Cancer Metastasis: Molecular Regulation of Endothelial Recruitment by Cancer Cells & Regulation of Metastasis Suppressor Micrornas
… cancer cells. Through coordinate targeting of IGFBP2, PITPNC1 and MERTK, miR-126 inhibits endothelial recruitment, which is required for metastatic angiogenesis and metastatic colonization. IGFBP2 secreted by metastatic cells promotes endothelial recruitment through binding of IGF-1 in the …
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Molecular regulation of neuronal apoptosis in PC12 cells.
… 8 hours of VM26 exposure, clusterin (TRPM-2) and IGFBP2 (Insulin-like growth factor binding protein 2) were both upregulated by 3 and 4 fold respectively. Cathepsin B (RSG-2) and RSG-3 (embigin) exhibited marginal changes in expression, only about 1.2 fold, over the 24 hour time course. Finally, …
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The Potential Role of Insulin (and Stress Response) Pathway Components In Breast Cancer Development and Progression
… in insulin-signaling pathway genes, IGF1, TSC1, IGFBP2, IRS1, TCF7L2, IGF1R, and PPARA, if significantly associated with tumor receptor status, provide evidence for a connection between insulin metabolism and the determination of breast tumor subtypes. The CC genotype of the TSC1 polymorphism …
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An in vivo study of novel genetic modifiers in autosomal recessive polycystic kidney disease (ARPKD)
… analysis also identified Aqp2, Foxf1 and Igfbp2 as novel Pkhd1 targets in the lung, as well as dysregulation of STAT3 signalling in Pkhd1T37M/T37M mice. Together, this data further highlights potential mechanisms of action for the lung phenotype and sets the ground for future …
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Characterisation of the effects and mechanism of action of rapamycin and genistein on acute myeloid leukemia using high-throughput techniques
… at 16 h. Interestingly, rapa down-regulated IGFBP2, usually elevated in AML patients. Our study showed that rapa represses Skp2, an important constituent of the protein ubiquitination pathway. Working on this clue, we identified that the time dependent G1 arrest is in fact the result of the …
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IGF2R: A NEW PLAYER IN THE INSULIN LIKE GROWTHFACTOR 2 (IGF2) PATHWAY SUSTAINING ADRENOCORTICAL TUMOURS CELL GROWTH
… and due to the increase of IGF binding proteins (IGFBP2 and 6) induced by RA, that determined the extracellular sequestering of IGF2. We also confirmed the pro-apoptotic effect of RA, even though it was not attributable only to IGF2R. The downstream mechanism of IGF2R was object of study in other …