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Showing 1 to 4 of 4 for “"IGFBP-6"”.
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Insulin-Like Growth Factor Binding Protein-6: Posttranslational modifications and sorting in polarized MDCK cells
… IGF-Bindungsproteinen ("IGF-binding proteins", IGFBPs) moduliert. Unter den IGFBPs hat IGFBP-6 die höchste Bindungsaffinität für IGF II. Die begrenzte Proteolyse von IGFBPs durch spezifische Proteasen verringert die Affinität der IGFBPs für IGFs, was in einem höheren Gehalt an freien IGFs …
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Alterazioni immunologiche su cellule mesenchimali stromali e linee cellulari di Leucemia Mieloide Cronica (LMC)
… e carcinogenesi. Diversi studi dimostrano che l'IGFBP-6 può sia inibire che stimolare la crescita in diversi tipi di tumore, rendendolo un target interessante da studiare. Come l'IGFBP-6, anche le disregolazioni SHH sono coinvolte nello sviluppo e nella progressione di diversi tipi di cancro. …
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Functional analysis of insulin-like growth factor binding protein -4 and -6 in transgenic mice
… a family of six secreted IGF-binding proteins (IGFBP-1 to -6). Although the six conserved IGFBPs are structurally related, each of them has specific characteristics and may have specific functions. Most knowledge about the IGFBPs has been gained from the numerous in vitro studies, their specific …
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Regulation of the Insulin-like Growth Factor System by Retinoic Acid in Human Osteoblast Cells
… and are modulated by six IGF binding proteins (IGFBPs) which either inhibit or enhance IGF action. The effect of RA on the IGF system in HBCs has not yet been determined. Therefore, because RA inhibits and IGFs stimulate proliferation and differentiation, I tested the hypothesis that RA inhibits …