Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"IGFBP-2"”.
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Studies to identify and characterise IGF-binding determinants of IGFBP-2 / by Graham D. Hobba.
… and characterises specific residues of bIGFBP-2 that comprises the IGF binding site.
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Leptin and the Control of Body Weight and Metabolism: Role for Stearoyl CoA Desaturase-1 and Other Leptin-Regulated Genes in the Liver
… insulin-like growth factor binding protein-2 (IGFBP-2). SCD-1 was specifically repressed during leptin-mediated weight loss, and mice lacking SCD-1 showed markedly reduced adiposity on both a lean (abJ/abJ) and ob/ob background (abJ/abJ; ob/ob), despite higher food intake. abJ/abJ; ob/ob mice …
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Proto-oncogene Regulation by Growth Factors in Bone Cells
… cells also produce two IGF binding proteins--MC-IGFBP-1 and MC-IGFBP-2. The major BP, MC-IGFBP-1, has N-terminal sequence identity with CSF BP which is found in cerebrospinal fluid. The minor BP, MC-IGFBP-2, N-terminal has sequence identity with In-IGFBP which is found in human bone cell …
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Regulation of Bovine Mammary Epithelial Cell Response by Autocrine IGF-I and by Collagen I
… IGF-I and added IGF-I increased the amount of IGFBP-3 secreted by the cells into growth media. Additionally, it was hypothesized that the presence of collagen I, an important ECM protein, would alter the cell production of insulin-like binding protein-3 (IGFBP-3), a protein that modulates IGF-I …
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Recapitulation of Human Placental Insufficiency in a Novel Mouse Model :New Paradigm in Translational Research
… and IGF-2 and IGF binding proteins(IGFBP 2 and 6) by ELISA and gene expression by qPCR and GeneChip microarray analysis. RESULTS: Compared with control, MUAL caused significant decrease (11%) in mean birth weight (1.06 ± 0.13 g vs. 0.94 ± 0.13 g, p<0.001) but no difference in …
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Hypoxia-inducible factor-1 alpha (HIF-1alpha) and its role in the hypoxic preconditioning and gene expression patterns in zebrafish ( Danio rerio) embryos
… responsive genes were analysed by real time PCR. IGFBP-2 showed a significant decrease in expression in the HIF-1alpha deficient embryos, and EPO showed a significant increase in HIF-1alpha deficient embryos. All other genes examined showed no significant change between treated and control embryos.
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Roles of Zinc in Skeletal Muscle Cells Growth
… assay yielded affinities as follows IGF-1R > IGFBP-5 > IGF-2R > IGFBP-4 > IGFBP-2 ≈ IGFBP-3. The estimated Kd for zinc ranged from 27 nM to 340 nM. To test the hypothesis that zinc enhanced IGF activity through altering IGFBP binding to IGF, the effects of zinc on IGFBP-3 inhibition of …
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Regulation of IGF-1 bioactivity by dietary hormones, impact of glucagon and insulin-induced hypoglycemia
… und stimulierenden IGF-1 bindenden Proteinen (IGFBPs) bestimmt die IGF-1 Bioaktivität, die als die Fähigkeit von IGF-1 die Phosphorylierung von seinem Rezeptor und folglich seinem Signalsweg zu induzieren, identifiziert ist. Deshalb reicht die Messung der IGF-1 Bioaktivität aus, um Änderungen …
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Chondrocyte Regulation by IL-I and IGF-I: Interconnection Between Anabolic and Catabolic Factors
… I IGF receptor (IGF-IR), IGF binding proteins (IGFBPs), and endogenously-secreted IGF-I. Our experimental findings solidify the significance of IL-1 as a key regulator of IGF-I signaling within articular cartilage, demonstrating that regulation of the IGF-I system occurs through both direct …
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Insulin-Like Growth Factor Binding Protein-6: Posttranslational modifications and sorting in polarized MDCK cells
… IGF-Bindungsproteinen ("IGF-binding proteins", IGFBPs) moduliert. Unter den IGFBPs hat IGFBP-6 die höchste Bindungsaffinität für IGF II. Die begrenzte Proteolyse von IGFBPs durch spezifische Proteasen verringert die Affinität der IGFBPs für IGFs, was in einem höheren Gehalt an freien IGFs …
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The role of insulin-like growth factors in the fetus
… concentrations of IGFs, their binding proteins (IGFBPs) and PL during fetal life is poorly understood. The objective of this thesis is to characterise the influence of nutrition on the regulation of these hormones in the fetal circulation. Pregnant ewes were starved for 72 h and then refed for 48 …
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Expression and Regulation of the Insulin-like Growth Factor Axis Components in Rat Liver Myofibroblasts
… und sechs hochaffinen IGF-Bindungsproteinen (IGFBPs) ist an der Regulation von Metabolismus, Wachstums-, Differenzierungs- und Reparaturprozessen beteiligt und spielt möglicherweise eine wichtige Rolle für die Pathophysiologie der Leberfibrogenese. Das Hauptziel dieser Arbeit bestand daher …
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CHCHD2 and the tumor microenvironment in glioblastoma
… inducing the greatest secretion of CCL2, IGFBP-2, TIMP-4, angiogenin, and IGFBP-3. HMC3 conditioned media decreased expression of the system xc- antiporter and increased glutathione oxidation in mitochondria of U87 cells, while xCT expression and mitochondrial glutathione redox status in …