Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"IGF2R"”.
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IGF2R: A NEW PLAYER IN THE INSULIN LIKE GROWTHFACTOR 2 (IGF2) PATHWAY SUSTAINING ADRENOCORTICAL TUMOURS CELL GROWTH
… is involved another specific IGF2 receptor, IGF2R, which was historically addressed as anti-oncogenic, due to its role in promoting IGF2 lysosomal degradation. However, recent studies in other cancers determined a possible tumorigenic action of IGF2R. Thus, the main aim of this PhD project …
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Targeting extracellular matrix using siRNA for the treatment of liver fibrosis and pancreatic cancer
… for insulin-like growth factor 2 receptor (IGF2R) using the phage display technique, which significantly increased the binding affinity of nanoparticles to activated HSCs. In this chapter, we employed the IGF2R ligand peptide to improve the silencing efficiency and cellular uptake of the …
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Development of Targeted siRNA Therapeutics for Triple Negative Breast Cancer and Liver Fibrosis
… (HSCs). Insulin-like growth factor 2 receptor (IGF2R) is overexpressed in activated HSCs and therefore can be utilized for HSC-specific drug delivery. Compared to vitamin A and cholesterol, the IGF2R-specific peptide exhibited the highest targeting effect to human LX-2, rat HSC-T6 cell line, and …
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Imprinted Gene Expression and Phenotype of Bovine Concepti with Bos taurus and Bos indicus Genetics
… and splice variants of the imprinted IGF2 and IGF2R genes as well as their imprinted regulatory non-coding RNAs, H19 and AIRN, (ii) to analyse expression patterns of all identified transcripts in bovine pre- and postnatal tissues, and (iii) to investigate fetal genetic effects on gene …
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Discovery of PSMA-Specific Peptide Ligands and Development of A Noncovalent Method to Attach Chemical Moieties to siRNA
… was applied to deliver PCPB2 siRNA to high IGF2R expressed HSC-T6 cells by conjugation of a peptide-431, which is a targeting moiety of IGF2R. The formulated siPCPB2-PNA-peptide-431 demonstrates significantly higher cellular uptake and good silencing effect in HSC-T6 cells. In order to …
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The impact of placental SLC2A3 (GLUT-3) RNA interference on fetal growth and physiology at mid-gestation in sheep
… in IGF-2 (p ≤ 0.05), IGF1R (p ≤ 0.05), and IGF2R (p ≤ 0.05) expression. This suggests an apparent attempt to increase placental growth via IGF-2 acting through IGF1R, while IGF2R, which primarily acts to sequester and degrade IGF-2, doesn't allow placental growth to be overstimulated. While …
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Development of Protein Based PCBP2 siRNA Nanocomplex for Liver Fibrosis Therapy
… treat liver fibrosis. Cholesterol and IGF2R (insulin growth factor 2 receptor) specific peptide were used as targeting ligands to deliver the siRNA to HSCs. In Chapter 1, we briefly introduced the background about RNA interference (RNAi), liver fibrogenesis, markers of liver fibrosis, …
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AN ANALYSIS OF THE DIFFERENTIAL METHYLATION AND EXPRESSION OF IMPRINTED GENES IN M. M. MUSCULUS, M. M. DOMESTICUS, AND THEIR HYBRIDS
… examined were <em>H19</em>, <em>Nap1l5</em>, <em>Igf2r</em>, <em>Mcts2</em>, and <em>Mest</em>. Differences in the expression levels of each of these genes were observed within the parental and hybrid samples.</p>
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Genome-scale identification of cellular pathways required for cell surface recognition
… such associations. Using this method, I identify IGF2R as a binding partner for the R2 subunit of GABAB receptors, providing a mechanism for the internalisation and regulation of GABAB receptor signalling. The results here demonstrate that this single approach can identify the molecular nature and …
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Neuronale in-vitro Differenzierung von murinen homozygoten Pbx1 Knock-out embryonalen Stammzellen : ein System zum Studium der Funktion und zur Identifikation potentieller Zielgene des Pbx1-Homeoboxproteins während der zellulären Differenzierung
… traten bei WNT1, FGF15, IGF1, IGF2, IGF1R, IGF2R und Colipase besonders große Unterschiede im Vergleich der Genexpressionsmuster von PBX1(+/+)-, PBX1(+/-)- und PBX1(-/-)-ES-Zellen auf. <br>Die Ergebnisse unserer Untersuchungen lassen den Schluss zu, dass PBX1(-/-)-Zellen während der …
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Untersuchungen zu Bedeutung von TGF-β während der Entwicklung des Vorderhirns
… TGF-β Signale selbst ausüben können wie Smad7, Igf2r und Fstl3. Durch die Regulation von Genen, die an der Übertragung von Notch- und Wnt-Signalen beteiligt sind, konnte eine Interaktion von TGF-β Signalwegen mit den an vielfältigen Entwicklungsprozessen beteiligten Notch- und Wnt-Signalwegen …
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Novel Prognostic Markers and Therapeutic Targets for Glioblastoma
… We also discovered that expression of CDCP1, IGF2R, IRAK3, LATS2, PIK3CB, ULK4, or VRK1 in primary glioblastoma tumors was associated with tumor recurrence prognosis. To note, of these recurrent prognostic candidates, PIK3CB expression in recurrent tumor tissue had much higher expression …
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Infertility and infertility treatment: childhood cancer and epigenetic risks.
… buccal cell samples for two loci; IGF2 DMR0 and IGF2R. Subgroup analysis indicated potential lower methylation in those whose parents used ART for unexplained infertility. Correlation between lymphocyte and buccal cell samples was low for all loci. The combined results of all three studies …