Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"IGF1R Signalling"”.
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Heterogeneity and Impaired IGF1R Signalling in Aged B cell Development
… that make up an immunoglobulin BCR (IgM). Signalling via the interleukin-7 receptor (IL7R) and the preBCR are required for successful progenitor B cell development in mice. There has also been mounting evidence implicating insulin-like growth factor 1 receptor (IGF1R) signalling to …
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Investigation of IGF1R/IRS1 Signalling Mechanisms in B Cell Development
… receptor, pre-BCR and chemokine receptor type 4 signalling are well established in this process. There is now growing evidence supporting a role for Insulin-like Growth Factor 1 Receptor (IGF1R) signalling in progenitor B cell development. Studies report marked reduction of B cell progenitor …
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THERAPEUTIC POTENTIAL OF TARGETING THE FLNA-REGULATED WEE1 KINASE PATHWAY IN ADRENOCORTICAL CARCINOMAS.
… the insulin-like growth factor 1 receptor (IGF1R) signalling. Upregulation of Wee1 nuclear kinase, a key regulator of G2/M cell cycle checkpoint, was shown in mouse neural progenitor cells lacking FLNA, and it has been reported in several cancers. The first part of this PhD thesis is focused …