Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 31 for “"IGF1R"”.
-
Investigation of IGF1R/IRS1 Signalling Mechanisms in B Cell Development
… role for Insulin-like Growth Factor 1 Receptor (IGF1R) signalling in progenitor B cell development. Studies report marked reduction of B cell progenitor numbers and antibody diversity in aged mice and humans. The underlying mechanisms and causes are unclear. Genome-wide analysis of aged mouse BM …
-
Heterogeneity and Impaired IGF1R Signalling in Aged B cell Development
… insulin-like growth factor 1 receptor (IGF1R) signalling to progenitor B cell development at the Pro-B and Pre-B cell stages. Aged progenitor B cells exhibit reduced output, both in terms of cell number and immunoglobulin repertoire diversity. These defects are suggestive of disrupted …
-
Targeted Inhibition of Pi3K, Mtor, and Igf1R For The Treatment of Undifferentiated Pleomorphic Sarcoma
… activates insulin-like growth factor 1 receptor (IGF1R), potentially as a mechanism of adaptive resistance. Combined inhibition of PI3K, mTOR, and IGF1R via small molecule inhibitors resulted in a drastically reduced tumor volume <em>in vivo</em>, despite the lack of substantial antiproliferative …
-
IGF1R as a pharmacological target in allergic asthma and cancer-promoting factor in the lung tumor microenvironment
IGF1R (receptor del factor de crecimiento similar a la insulina tipo 1) es una tirosina quinasa ubicua que modula múltiples funciones celulares, como la proliferación, el crecimiento, la diferenciación y la supervivencia. El asma es una enfermedad pulmonar crónica caracterizada por obstrucción …
-
Implicación de igf1r en inflamación pulmonar aguda y en alergia inducida por ácaros del polvo doméstico en ratones
Background: IGF1R (Insulin-like Growth Factor 1 Receptor) is a ubiquitous tyrosine kinase that modulates multiple cellular functions including proliferation, growth, differentiation and survival. Since prenatal Igf1r knockout mice die shortly after birth, the generation of Igf1r conditional mutant …
-
RUOLO DELL'ISOFORMA A DEL RECETTORE INSULINICO E DEL SUO PARTNER MOLECOLARE DDR1 NEL CANCRO AL SENO
… infettando stabilmente le cellule MCF7 prive di IGF1R (MCF7 IGF1R-ve) con un cDNA di IR-A umano (MCF7 IGF1R-ve/IR-A). Abbiamo quindi valutato l'espressione di molecole chiave correlate al metabolismo e misurato i tassi di acidificazione extracellulare e i tassi di consumo di ossigeno in tempo …
-
Charakterisierung der Insulinrezeptor- / Insulin-Like-Growth-Factor 1-Rezeptor-Expression beim duktalen Adenokarzinom des Pankreas
… und des Insulin-like Growth Factor-1 Rezeptors (IGF1R) mit klinisch-pathologischen Patientencharakteristika und dem Überleben korreliert und damit möglichweise eine tumorbiologische Relevanz hat. Beim duktalen Adenokarzinom des Pankreas gibt es Präkanzerosen, wie die pankreatischen …
-
Characterization of The Growth Factor Receptor Network Oncogenes in Lung Cancer
… were generated of BAD (BAD), HER2 (ERBB2), IGF1R (IGF1R), RAF (RAF1), and KRAS (G12V), using the Bioconductor package, Adaptive Signature Selection and InteGratioN (ASSIGN). Gene lists of various lengths were generated ranging from 5 to 500 genes produced in 25 gene increments. Pathway …
-
Modulation of Pi3K-Akt Pathway In Colorectal Cancer
… insulin like growth factor 1 receptor (IGF1R) was significantly upregulated in patients, PDX and cell lines (P</p> <p>The PI3K pathway also modulates tumor immune microenvironment and may influence response to emerging immunotherapies. Using quantitative immunohistochemistry, we found …
-
Effects of somatic cell nuclear transfer on transcripts related to IGF signaling, EGF signaling and cell adhesion during the peri-implantation period in cattle
… enrichment analysis, integrin signaling, IGF1R signaling, EGFR/ERBB signaling, and PI3K/AKT and ERK1/2 signaling, two signal transduction pathways induced by integrin clustering and IGF1R and EGFR/ERBB activation, were significantly affected by both implantation and SCNT. In addition, …
-
Gene variations of FABP4, SCD, GH, and IGF1R and their associations with meat and carcass traits in sheep : A thesis submitted in fulfilment of the requirements for the Degree of Doctor of Philosophy at Lincoln University
… (GH) and insulin-like growth factor 1 receptor (IGF1R) with meat characteristics such as intramuscular fat (IMF) levels, fat percentage, fatty acid profile, and carcass traits. This understanding aims to facilitate the reliable production of juicy, flavourful, and healthier lamb while maintaining …
-
The impact of placental SLC2A3 (GLUT-3) RNA interference on fetal growth and physiology at mid-gestation in sheep
… in a significant increase in IGF-2 (p ≤ 0.05), IGF1R (p ≤ 0.05), and IGF2R (p ≤ 0.05) expression. This suggests an apparent attempt to increase placental growth via IGF-2 acting through IGF1R, while IGF2R, which primarily acts to sequester and degrade IGF-2, doesn't allow placental growth to be …
-
New biological mechanisms and intervention strategies in aging and cancer
… factor de envejecimiento asociado a insulina (IGF1R).
-
Analysis Of The Effects Of Metformin Administered Alone Or In Combined Treatments In Colorectal Cancer
… by the inactivation of the mTOR pathway and of IGF1R protein. However, the drug only transiently arrested cell growth, since its effects were reversed after drug removal. When I combined the biguanide with the chemotherapy drugs commonly used to treat CRC I observed different responses in the …
-
Refining the evaluation of growth and the growth hormone/insulin-like growth factor-I axis in children
… genetic studies, we have also identified a novel IGF1R mutation in a child with a phenotype consistent with IGF-I resistance. Conclusions: Diagnosing disorders of the GH/IGF-I axis remain a significant clinical challenge. I have expanded the clinical approach to evaluating the child with short …
-
The effects of virus-induced maternal inflammation on methylation patterns in skeletal muscle
… also present in the fast twitch muscle fibers, IGF1R, and several IGF binding proteins. Overall, there is evidence that maternal inflammation leads to hypermethylaiton of genes and decreased muscle growth during development.
Page 1 of 2