Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"IGF1"”.
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Modulation of bovine preimplantation embryonic development and pregnancy by FGF2, LIF, and IGF1
… factor (LIF), and insulin-like growth factor 1 (IGF1) as a cytokine cocktail named FLI, was first recognized for its role in embryonic stem cell derivation and then for improvements to in vitro porcine embryo production. These same three cytokines have been identified as embryokines in the cow …
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The Insulin-Like Growth Factor-1 (IGF1) System as a Potential Biomarker for Nutritional Status and Growth Rate in Pacific Rockfish (SEBASTES SPP.)
… concentrations of insulin-like growth factor-1 (Igf1) correlate positively with growth rate, and it has been proposed that plasma Igf1 levels may serve as an indicator of growth variation for fisheries and aquaculture applications. Here, I tested whether plasma Igf1 concentrations might serve as …
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The neural cell adhesion molecule 2 (NCAM2) promotes excitatory synapse formation through increasing insulin and insulin-like growth factor 1 receptor signaling
… receptor and insulin-like growth factor 1 (IGF1) receptors underlies the pathogenesis of intellectual disability. NCAM2 is enriched at excitatory synapses and is involved in synapse maturation and maintenance. The role of NCAM2 in the regulation of synaptogenesis, however, remains poorly …
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The regulation of post-natal growth in sheep through the growth hormone - insulin-like growth factor axis
… were used to measure receptors for GH, IGF1 and IGF2 in skeletal muscle of prepubertal lambs which had undergone treatment with exogenous growth factors and/or degrees of nutritional restriction before slaughter. Plasma concentrations of IGF1 were positively correlated with good …
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Additive effects among uterine paracrine factors in promoting bovine trophoblast cell proliferation
… (FGF2) and insulin-like growth factor-1 (IGF1) promote bovine trophoblast cell proliferation, and to decipher the intracellular signaling mechanisms employed by these growth factors to regulate cell proliferation. Pilot studies established effective concentrations for each growth factor on …
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The Influence of Insulin-like Growth Factor Pathway Gene Polymorphisms on the Strength Training Response of Muscle Phenotypes in Older Adults
… region of the insulin-like growth factor 1 (IGF1) gene influenced the muscle strength response to ST in Caucasians. Other studies have shown that the insulin-like growth factor binding protein-3 (IGFBP-3) is a modulator of IGF-1 in circulation and is present in skeletal muscle. The -202 …
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Growth factors in extraocular muscles: effects on contractile properties
… I examined the effects of three growth factors, IGF1 (Insulin-like Growth Factor 1), CT1 (Cardiotrophin 1), and GDNF (Glial-cell line derived neurotrophic factor), on contractile properties of extraocular muscles, and I provide evidence that these growth factors regulate development and …
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A functional analysis of growth hormone receptor promoter regions in swine
… P1KO pigs exhibited normal hepatic GHR and IGF1 expression, normal circulating GH and IGF1 concentrations, and no differences in postnatal growth compared with wildtype (WT) littermates. In contrast, P2KO pigs showed marked reductions in GHR1B, total GHR, and IGF1 mRNA in both liver and …
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Regulation of skeletal muscle growth and gene expression by insulin-like growth factors and myostatin
… 0.12) expression of other growth factors such as IGF1 and myostatin. The final objective was to determine how IGF1 and IGF2 cooperate with myostatin to regulate skeletal muscle growth. Therefore, we quantified IGF family member expression in myostatin null (MN) and wild type mice. Skeletal muscle …
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Heterogeneity and Impaired IGF1R Signalling in Aged B cell Development
… insulin-like growth factor 1 receptor (IGF1R) signalling to progenitor B cell development at the Pro-B and Pre-B cell stages. Aged progenitor B cells exhibit reduced output, both in terms of cell number and immunoglobulin repertoire diversity. These defects are suggestive of disrupted …
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Genes with Physiological Roles in Callipyge Muscle Hypertrophy
… myosin expression than Park7 (-/-) myotubes. IGF1 treatment increased the mRNA abundance of Myh4, Myh7 and Myh8 between 20-40% in Park7 (+/+) myotubes relative to Park7 (-/-). The activity of PI3K/AKT pathway was determined by examination the level of phosphorylation of AKT. The basal level of …
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Influence of Insulin, Insulin-Like Growth Factor I and Sex Steroids On the Regulation of the Vitellogenin Receptor In Developing Oocytes of Largemouth Bass (Micropterus Salmoides)
… and insulin-like growth factor-1 (<italic>igf1</italic>). Using <italic>ex vivo</italic> experiments it was determined that both Insulin and IGF1 induce the expression of <italic>vtgr</italic> in ovarian follicles in early growth stages. Preliminary studies suggest involvement of MAPK …
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The Effect of Training Volume and Intensity on Improvements in Muscular Strength and Size in Resistance-trained Men
… hormone (GH), insulin-like growth factor-1 (IGF1), cortisol (CORT), and insulin. Area under the curve analysis revealed a greater (p < 0.05) increase for VOL (WK3: GH & CORT; WK10: CORT) compared to INT. Compared to WK3, WK10 showed reduced responses for VOL (GH and CORT) and INT (IGF1). …
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Genetic polymorphisms in breast cancer in relation to risk and prognosis
… allele in the insulin-like growth factor 1 gene (IGF1-19/-19) has been shown to modify the effect of several breast cancer risk factors. In Study I multiparous patients with IGF1-19/-19 were 5.9 years younger at diagnosis than all other patients (P=0.007). Women with this combination may thus …
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Post-Transfer Outcomes in Cultured Bovine Embryos Supplemented with Epidermal Growth Factor, Fibroblast Growth Factor 2, and Insulin-Like Growth Factor 1
… 2 (FGF2), and insulin-like growth factor 1 (IGF1) (collectively termed EFI) was recently identified as a means for improving in vitro derived bovine embryo development and trophectoderm cell numbers. The objectives of this work were to determine if EFI treatment during in vitro bovine embryo …
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Nmp4 restricts bone marrow osteoprogenitors and parathyroid hormone induced bone formation in healthy and estrogen depleted female mice
… of synthetic processes and suggested the IGF1/Akt and BMP2/Smad biochemical pathways which are likely targets for Nmp4 regulation. We have experimentally verified these pathways in immortalized bone marrow mesenchymal cells from wild type and Nmp4-KO mice. Disabling Nmp4 in estrogen …
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Studies into the receptor-mediated induction of hypoxia inducible factor 1α.
… auto-phosphorylation of insulin and IGF1 receptors (IR and IGFRI) clearly indicated that these cells possess functional insulin and IGF receptor signalling pathways. However, as non-physiological (100 nM) concentrations of insulin were required to achieve an induction of the …
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Effects of close-up dietary energy strategy and prepartal dietary monensin on hepatic mRNA expression of enzymes involved in glucose and lipid metabolism in transition cows
… GSTM1), growth hormone/IGF-1 axis genes (GHR, IGF1) and transcription factors (FOXA2, HNF4A, NR4A1, SREBPF2). In cows fed the CON diet, serum NEFA concentrations were higher at -2 and -1 week relative to calving and serum BHBA concentrations were also higher at -2 wk. We also observed a lower …
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Obesity-Induced Alterations in Sperm Quality, Testicular Morphology, and Extracellular Vesicle Localisation in Male Mice
… via WB for spermatogenesis-related proteins (IGF1, INSL6, and PRDX2). For EV extraction, frozen testes were dissociated and underwent differential centrifugation after which WB was performed to confirm EV isolation by targeting EV-specific biomarkers. Results: At 16-weeks old, obese mice had …
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