Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 20 for “"IGF-binding proteins"”.
-
The Role of Insulin-like Growth Factor-I and IGF-binding Proteins in Mammary Gland Development
… synthesis of insulin-like growth factor-I (IGF-I) and IGF-binding proteins (IGFBP), the initial objective was to evaluate the physiological effects of recombinant IGF-I synthesis in the mouse mammary gland. Expression of recombinant IGF-I was targeted by the mouse mammary tumor virus - long …
-
IGFBP-3 blocks hyaluronan-CD44 signaling, leading to increased acetylcholinesterase levels in A549 cell media and apoptosis in a p53-dependent manner
<p>Insulin-like growth factor binding protein-3 (IGFBP-3) belongs to a family of six IGF binding proteins. We previously found that IGFBP-3 exerts its cytotoxic effects on A549 (p53 wild-type) cell survival through a mechanism that depends on hyaluronan-CD44 interactions. To shed light on the …
-
Quantification of the Binding of Insulin-like Growth Factor-I (IGF-I) and IGF Binding Protein-3 (IGFBP-3) Using Surface Plasmon Resonance
… in a variety of mammalian cells through the IGF-I cell surface receptor (IGF-IR). A unique feature of the IGF-I system is the regulation of this binding by soluble IGF binding proteins. Recent studies from our laboratory show that there is a pH dependence in the association of IGF-I with the …
-
The effects of virus-induced maternal inflammation on methylation patterns in skeletal muscle
… also present in the fast twitch muscle fibers, IGF1R, and several IGF binding proteins. Overall, there is evidence that maternal inflammation leads to hypermethylaiton of genes and decreased muscle growth during development.
-
Recapitulation of Human Placental Insufficiency in a Novel Mouse Model :New Paradigm in Translational Research
… of placental insulin-like growth factors-1(IGF-1) and IGF-2 and IGF binding proteins(IGFBP 2 and 6) by ELISA and gene expression by qPCR and GeneChip microarray analysis. RESULTS: Compared with control, MUAL caused significant decrease (11%) in mean birth weight (1.06 ± 0.13 g vs. 0.94 ± …
-
Molecular interactions among insulin-like growth factor, its receptor and binding proteins on myeloid cells
… mechanism by which insulin-like growth factor-I (IGF-I), a mediator of GH's action, acts on cells of immune system, the expression of IGF-I, IGF-I receptor (IGF-IR) and IGF binding proteins (IGFBP) in myeloid cells were studied. Human myeloid cell lines expressed IGF-I mRNA and probably secreted …
-
Chronic Shear Stress Effects on Endothelial Cell Response
… proteoglycans and insulin-like growth factor-I (IGF-I) and related IGF binding proteins (IGFBPs) in bovine aortic endothelial cells cultured under chronic pulsatile shear. We found that shear stress increased the release of proteoglycans and significantly altered proteoglycans distribution. We …
-
The Role of Exogenous Somatotropin, Ovariectomy and Extracellular Matrix in Bovine Mammary Gland Development
… role of ovarian hormones, growth hormone (GH)/IGF axis proteins and extracellular matrix (ECM) in the growth and development of prepubertal mammary glands. Prepubertal heifers were injected with either exogenous GH or subjected to ovariectomy (OVX). Mammary parenchyma (PAR) and mammary fat pad …
-
Autocrine mechanisms of action of insulin-like growth factor-I (IGF-I) and hormonal regulation of expression of IGF-finding proteins in mammary epithelial cells
… expression of insulin-like growth factor-I (IGF-I) and IGF-binding proteins (IGFBPs) genes in mammary epithelial cells. To test the hypothesis that IGF-I affects growth of bovine mammary epithelial cells through an autocrine and/or paracrine pathway, several cell lines were developed …
-
Proto-oncogene Regulation by Growth Factors in Bone Cells
… work, MC3T3-E1 cells are now known to produce IGF-I, TGF-beta and IGF-II in descending order of abundance. These growth factors also act on MC3T3-E1 cells in an autocrine manner. IGF-I and IGF-II increase while TGF-beta decreases cell proliferation as measured by <sup>3</sup>H thymidine …
-
Chondrocyte Regulation by IL-I and IGF-I: Interconnection Between Anabolic and Catabolic Factors
… (IL-1) and insulin-like growth factor-I (IGF-I). These factors have antagonistic effects on chondrocyte activity, and during the progression of osteoarthritis, IL-1 is thought to promote chondrocyte hyporesponsiveness to IGF-I. To better understand how the anabolic (IGF-I) and catabolic …
-
Mechanism of Mitogenic Action of Aluminum Ion on Bone Cells : Potential Involvement of the Insulin-Like Growth Factor Regulatory System
… mediated through the insulin-like growth factor (IGF) regulatory system, the effects of mitogenic concentrations of aluminum on IGF-I and IGF-II production were evaluated. TE85 cells treated with aluminum ion for 48 hours showed biphasic stimulation of the synthesis/secretion of IGF-I and IGF-II …
-
Regulation of the Insulin-like Growth Factor System by Retinoic Acid in Human Osteoblast Cells
… <p>The insulin-like growth factor (IGF) system is an important local regulator of bone cell proliferation and differentiation. The actions of IGF are mediated through IGF receptors and are modulated by six IGF binding proteins (IGFBPs) which either inhibit or enhance IGF action. The …
-
Microphysiometry Studies of Rapid Binding of Insulin-Like Growth Factor I by Parental and Transfected Mammary Epithelial Cell Lines
… of the family of insulin-like growth factors (IGFs) are proposed to play a major role in the development and subsequent uncontrolled proliferation of breast cancer cells. Insulin-like growth factor-I (IGF-I) is known to be a potent mitogen for mammary epithelial cells. IGF-I acts by binding to …
-
Insulin-Like Growth Factor Binding Protein-6: Posttranslational modifications and sorting in polarized MDCK cells
… ("insulin-like growth factors", IGFs) stimulieren Wachstum und Differenzierung verschiedener Zelltypen. Die Verfügbarkeit der IGFs und ihre Interaktion mit spezifischen IGF- Zelloberflächenrezeptoren werden von sechs strukturell ähnlichen IGF-Bindungsproteinen ("IGF-binding …
-
IGF2R: A NEW PLAYER IN THE INSULIN LIKE GROWTHFACTOR 2 (IGF2) PATHWAY SUSTAINING ADRENOCORTICAL TUMOURS CELL GROWTH
… interest, the insulin-like growth factor 2 (IGF2), overexpressed in the majority of ACC, is a growth factor responsible for the autocrine proliferative loop that sustains ACC growth. In the IGF2 system, two well addressed tyrosine-kinase receptors, IGF1R and IR, were found responsible for the …
-
Functional analysis of insulin-like growth factor binding protein -4 and -6 in transgenic mice
Insulin-like growth factors (IGF-I and IGF-II) are expressed in many cell types and tissues and act in endocrine, autocrine or paracrine manner to regulate cellular proliferation, survival and differentiation. IGF actions are initiated upon binding to the type I IGF receptor (IGF-IR) and are …
-
The role of growth factors in the regeneration of skeletal muscle
… components of the insulin-like growth factor (IGF) axis during regeneration, to determine whether these factors were temporally regulated during regeneration, whether the absence or presence of growth hormone (GH) affected their levels, and lastly, whether the administration of exogenous IGF-II …
-
THE METABOLIC EFFECTS OF DIET-INDUCED OBESITY AND GROWTH HORMONE TREATMENT IN LONG-LIVED MICE WITH ALTERED INSULIN AND INSULIN-LIKE GROWTH FACTOR -1 SIGNALING
… types of diets that have negative impact on IGF-1 and insulin signaling. To examine high calorie diet and GH-treatment effects in long-lived mice, we designed a three part study using hypopituitary Ames dwarf mice that have primary altered endocrine signaling and Pregnancy Associated Plasma …