Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"IGF-IR"”.
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The Role of Type I Insulin-Like Growth Factor Receptor Signaling In Breast Cancer Brain Metastasis
… 20-30% of breast cancer patients acquire brain metastasis, yet potential therapeutic targets remain largely unknown. The type I insulin-like growth factor receptor (IGF- IR) is known to play a role in the progression of breast cancer and is currently being investigated in the clinical …
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The role of receptor tyrosine kinase signalling in HER-2-positive cells and trastuzumab (Herceptin) resistance in breast cancer
… such as insulin-like growth factor I receptor (IGF-IR), has been implicated in resistance to Tmab. The main aim of this study was to investigate mechanisms of resistance and in particular the role of IGF-IR in resistance to Tmab. Response to Tmab was analysed in a panel of HER-2-positive breast …
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Type I Insulin-Like Growth Factor Receptor Tyrosine Kinase As A Molecular Target In Mantle Cell Lymphoma
… The type I insulin-like growth factor receptor (IGF-IR) is thought to be a key player in several different solid malignancies such as those of the prostate, breast, lung, ovary, skin and soft tissue. In addition, recent studies in our lab showed evidence to support a pathogenic role of IGF-IR in …
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Expression and Regulation of the Insulin-like Growth Factor Axis Components in Rat Liver Myofibroblasts
… für die Pathogenese der Leberfibrose. Das IGF-System bestehend aus den Insulin-ähnlichen Wachstumsfaktoren I und II (IGF-I, -II), ihren Rezeptoren (IGF-I-Rezeptor, IGF-IR; IGF-II/Mannose-6-Phosphat-Rezeptor, IGF-II/M6-PR) und sechs hochaffinen IGF-Bindungsproteinen (IGFBPs) ist an der …
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Multilevel Deregulation of Survival Mechanisms In Npm-Alk+ T-Cell Lymphoma
… this superfamily include the insulin receptor (IR), type I insulin-like growth factor receptor (IGF-IR), and the leukocyte tyrosine kinase. The common structural finding among these tyrosine kinases is the Y<em>XXX</em>YY<em> </em>motif present within their respective tyrosine kinase domains. …
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Isolation and functional analysis of differentially expressed genes in human prostate cancer
… dass der Insulin-like growth factor I receptor (IGF-IR) eine wichtige Rolle in der zellulären Homöostase von Prostatakarzinomen spielt. Daher wurde die antisense-RNA-Strategie genutzt, um die endogene IGF-IR Genexpression in menschlichen Prostatakarzinom PC-3 Zellen zu reduzieren, was in einer …
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EFFETTI CLINICI E PLACENTARI DELL IPERGLICEMIA IN GRAVIDANZA IN DONNE CON DIABETE MELLITO
… a una disregolazione del sistema insulina/IGF che possono essere responsabili di un alterato trasporto di nutrienti al feto e di un aumentata crescita fetale. In queste donne la valutazione del sistema insulina/IGF placentare può fornire importanti informazioni sui meccanismi delle …
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Effects of Growth Hormone and Insulin-Like Growth Factor-I on Milk Protein Gene Expression and Nutrient Uptake and Cell Proliferation in Clonal Bovine Mammary Epithelial Cells
… were conducted toward this objective. In the first study, the effects of GH and insulin-like growth factor-I (IGF-I), a major mediator of GH action in vivo, on cell proliferation, nutrient transport, and milk protein gene expression in bovine mammary epithelial cell line MAC-T cells were …
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Molecular interactions among insulin-like growth factor, its receptor and binding proteins on myeloid cells
… mechanism by which insulin-like growth factor-I (IGF-I), a mediator of GH's action, acts on cells of immune system, the expression of IGF-I, IGF-I receptor (IGF-IR) and IGF binding proteins (IGFBP) in myeloid cells were studied. Human myeloid cell lines expressed IGF-I mRNA and probably secreted …
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Effect of the Insulin-like Growth Factor (IGF) Axis on the Transport Properties of Endothelial and Epithelial Cells In Vitro
… provide evidence that autocrine production of IGF-I modulates tight junction permeability and (2) demonstrate the ability of IGFBPs to regulate IGF-I delivery across cell layers. To meet the first objective, parental and IGF-I secreting bovine mammary epithelial cells were tested for cell layer …
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Regulation of Bovine Mammary Epithelial Cell Response by Autocrine IGF-I and by Collagen I
Understanding how insulin-like growth factor-I (IGF-I) signaling in mammary epithelial cells may be modified or interrupted by modifications in the cellular environment may lead to 1) methods to increase the growth and proliferation of normal mammary epithelial cells for an increase in the amount …
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Obesity and Aggressive Prostate Cancer: Bias and Biology
… PC due to its associations with altered circulating levels of metabolic and sex steroid hormones involved in prostate development as well as oncogenesis. However, the current observational evidence linking obesity to aggressive PC is inconsistent or conflicting, and there is growing …
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Chondrocyte Regulation by IL-I and IGF-I: Interconnection Between Anabolic and Catabolic Factors
… (IL-1) and insulin-like growth factor-I (IGF-I). These factors have antagonistic effects on chondrocyte activity, and during the progression of osteoarthritis, IL-1 is thought to promote chondrocyte hyporesponsiveness to IGF-I. To better understand how the anabolic (IGF-I) and catabolic …
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Quantification of the Binding of Insulin-like Growth Factor-I (IGF-I) and IGF Binding Protein-3 (IGFBP-3) Using Surface Plasmon Resonance
… in a variety of mammalian cells through the IGF-I cell surface receptor (IGF-IR). A unique feature of the IGF-I system is the regulation of this binding by soluble IGF binding proteins. Recent studies from our laboratory show that there is a pH dependence in the association of IGF-I with the …
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Insulin-Like Growth Factor-Binding Protein 2 Supports Hematopoietic Stem Cell Expansion: From In Vitro to In Vivo
… insulin-like growth factor binding protein 2 (IGFBP2), secreted by a tumorigenic cell line, also enhanced ex vivo expansion of mouse HSCs. As measured by competitive repopulation analyses, there was a 48-fold increase in numbers of long-term repopulating mouse HSCs after 21 days of culture. …
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Regulation of IGF-i Signaling by SOCS3 in Human Coronary Artery Smooth Muscle Cells
… in inflammation. Insulin-like growth factor (IGF-i) is one of the most potent inducers of proliferation in hCASMCs, mainly through the activation of phosphatidyl inositol3 (Pl3)-Kinase and mitogen induces protein (MAP) Kinase pathways. Cytokines on the other hand use other pathways such as …
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Functional analysis of insulin-like growth factor binding protein -4 and -6 in transgenic mice
Insulin-like growth factors (IGF-I and IGF-II) are expressed in many cell types and tissues and act in endocrine, autocrine or paracrine manner to regulate cellular proliferation, survival and differentiation. IGF actions are initiated upon binding to the type I IGF receptor (IGF-IR) and are …