Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"IGF-I receptor"”.
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Insulin -Like Growth Factors Regulate Cardiac Hypertrophy
Interestingly, exogenous IGF-I or IGF-I receptor antibodies also lead to hypertrophy of adult cardiomyocytes. This induction appears to be mediated by the local production of IGF-II, that this growth factor then stimulates the hypertrophy via an IGF-I receptor-independent, IGF-II-responsive pathway …
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The Role of Tyrosine Kinase Growth Factor Receptors in Psoriatic Epidermal Hyperplasia: Analysis of Growth Factor Synergy in Cultured Human Keratinocytes and Receptor Expression in Psoriatic Skin
… the disease. The epidermal growth factor (EGF) receptor pathway is an important mediator of keratinocyte growth and both ligand and receptorcomponents of this pathway are abnormally expressed in hyperproliferative epidermis. In contrast, little is known about the function of other growth factor …
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The effect of insulin-like growth factor-I (IGF-I), and an IGF-I-like factor secreted by human lung fibroblasts, on the growth of human lung carcinoma cells in vitro
… concentration of insulin-like growth factor I (IGF-I) in tissue taken from human non-small cell lung carcinoma (NSCLC) is 1.4- to 7-fold higher than the concentration of IGF-I in the surrounding normal lung tissue and therefore IGF-I may be involved in the growth of NSCLC. In this study it was …
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Somatolactogenic hormones and interferon-gamma as regulators of neutrophil activation
… promoting peptide, insulin-like growth factor-I (IGF-I), were both comparable to IFN-$\gamma$ in augmenting the secretion of O$\sb2\sp-$ by PMN. These results indicated that the IGF-I receptor was not essential for GH-mediated priming. However, PRL was able to prime human PMN as well as human GH, …
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Regulation of Bovine Mammary Epithelial Cell Response by Autocrine IGF-I and by Collagen I
Understanding how insulin-like growth factor-I (IGF-I) signaling in mammary epithelial cells may be modified or interrupted by modifications in the cellular environment may lead to 1) methods to increase the growth and proliferation of normal mammary epithelial cells for an increase in the amount …
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Regulation of protein metabolism in skeletal muscle of low-birth-weight neonatal pigs
… Plasma and muscle insulin-like growth factor (IGF)-I was diminished in LBWT compared with NBWT pigs. In addition, reduced activation of key components of IGF-I downstream signaling pathway in LBWT pigs muscle may lead to diminished translation initiation signaling and thus decreased protein …
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Molecular interactions among insulin-like growth factor, its receptor and binding proteins on myeloid cells
… mechanism by which insulin-like growth factor-I (IGF-I), a mediator of GH's action, acts on cells of immune system, the expression of IGF-I, IGF-I receptor (IGF-IR) and IGF binding proteins (IGFBP) in myeloid cells were studied. Human myeloid cell lines expressed IGF-I mRNA and probably secreted …
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Autocrine mechanisms of action of insulin-like growth factor-I (IGF-I) and hormonal regulation of expression of IGF-finding proteins in mammary epithelial cells
… expression of insulin-like growth factor-I (IGF-I) and IGF-binding proteins (IGFBPs) genes in mammary epithelial cells. To test the hypothesis that IGF-I affects growth of bovine mammary epithelial cells through an autocrine and/or paracrine pathway, several cell lines were developed …
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Regulation of the Insulin-like Growth Factor System by Retinoic Acid in Human Osteoblast Cells
… <p>The insulin-like growth factor (IGF) system is an important local regulator of bone cell proliferation and differentiation. The actions of IGF are mediated through IGF receptors and are modulated by six IGF binding proteins (IGFBPs) which either inhibit or enhance IGF action. The …
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Resveratrol Regulates IGF- II and Cathepsin D in Breast Cancer Cells
… growth and cell death. RSV binds to estrogen receptors (ER) and functions as a mixed estrogen agonist/antagonist. The mechanism by which RSV regulates breast cancer growth is largely unknown, but it likely targets factors regulated by estrogens. Insulin-like growth factor II (IGF-II) and its …
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Effects of Growth Hormone and Insulin-Like Growth Factor-I on Milk Protein Gene Expression and Nutrient Uptake and Cell Proliferation in Clonal Bovine Mammary Epithelial Cells
… effects of GH and insulin-like growth factor-I (IGF-I), a major mediator of GH action in vivo, on cell proliferation, nutrient transport, and milk protein gene expression in bovine mammary epithelial cell line MAC-T cells were determined. GH increased (P < 0.01) expression of four major milk …
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Estrogen Receptor-Mediated Effects in the Gonadotropic LBetaT2 and AlphaT3-1 Cell lines
… α-gonadotropine subunit en een functionele GnRH receptor tot expressie, maar verschillen in differentiatiegraad. De LβT2 cellijn vertoont structurele en functionele karakteristieken van volwassen hypofysaire gonadotropen. De αT3-1 cellijn daarentegen is minder gedifferentieerd door de afwezigheid …
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Obesity and Aggressive Prostate Cancer: Bias and Biology
… we measured nuclear expression or androgen receptor (AR), epithelial insulin like growth factor I receptor (IGF-IR), and proliferation marker Ki67, in 357 cases who received a RP. We then tested for associations between patient history of obesity and other demographic and clinical …
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Regulation of IGF-i Signaling by SOCS3 in Human Coronary Artery Smooth Muscle Cells
… in inflammation. Insulin-like growth factor (IGF-i) is one of the most potent inducers of proliferation in hCASMCs, mainly through the activation of phosphatidyl inositol3 (Pl3)-Kinase and mitogen induces protein (MAP) Kinase pathways. Cytokines on the other hand use other pathways such as …