Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"IGF-1R"”.
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Interrogating regulated intramembrane proteolysis of IGF-1R, and its role in cell migration
The IGF-1R has long been implicated in numerous malignant characteristics of cancers including enhanced proliferation, insensitivity to apoptosis, chemoresistance, increased migratory and invasive capacity, epithelial-to-mesenchymal transition, and metabolic augmentation. IGF-1R, much like other …
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Targeting the Notch-1/IGF-1R/Akt Axis in at Orthotopic Model of Advanced Non-Small Cell Lung Cancer
… signals to NSCLC cells by positively regulating IGF-1R to activate the Akt-1 pathway. Therefore, the overall hypothesis is that an inhibitor of Notch activation, such as γ-secretase inhibitor (GSI) MRK-003; or a fully humanized antibody against the human IGF-1R that promotes the receptor …
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Insulin-like growth factor receptor activity in cancer biology & therapy responses
The Insulin-like Growth Factor 1 Receptor (IGF-1R) has an essential function in normal cell growth and in cancer progression. However, anti-IGF-1R therapies have mostly been withdrawn from clinical trials owing to a lack of efficacy and predictive biomarkers. IGF-1R activity and signalling in …
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A study on the interactions of synthetic IGF-II analogues with the type 1 IGF and insulin receptors.
Insulin-like growth factor II (IGF-II) is a unique regulatory peptide containing 67 residues and three disulfide bonds. It binds with high affinity to three receptors, the insulin receptor (IR), the type 1 insulin-like growth factor receptor (IGF-1R) and the We 2 insulin-like growth factor receptor …
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Correlación entre los datos clínico-patológicos y la expresión de los marcadores inmunohistoquímicos c-MET, IGF-1R y VEGFR-2 como factores pronósticos en el adenocarcinoma gástrico
… tumoral. HIPÓTESIS La expresión de c-MET, IGF-1R y VEGFR-2 en el tejido gástrico tumoral puede tener un valor pronóstico de recurrencia en adenocarcinoma gástrico y podría relacionarse con variables clínicas y patológicas. OBJETIVOS Determinar mediante inmunohistoquímica el grado de …
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Die prognostische Relevanz der Insulinrezeptor- und Insulin-like growth factor-1-Rezeptorexpression beim kolorektalen Karzinom
… des Insulin-like growth factor 1 Rezeptors (IGF-1R) im kolorektalen Karzinom zu untersuchen und deren Zusammenhang mit klinisch-pathologischen Parametern und dem Überleben zu analysieren. Zusätzlich wurde die Isoform A des IR betrachtet. In einem Kollektiv von 1580 Tumoren wurde die …
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The Role of Dna Methylation and Hydroxymethylation In Smooth Muscle Cell Phenotypic Change During Atherogenesis
… in insulin-like growth factor 1 receptor (IGF-1R) expression during atherogenesis triggered by genetic knockout of ApoE and/or the addition of high fat.</p> <p><strong>Methods and Results.</strong> Atherosclerosis is a chronic arterial disease systemically impacting the function of organs …
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Regulation Of Membrane-Type 1 Matrix Metalloproteinase In Prostate Cancer
… also identified the insulin-like growth factor (IGF-1R) as an upstream regulatory component of MT1-MMP in PC-3N and LNCaP cells, which express high and low levels of the enzyme, respectively. Treatment of PC-3N cells with an IGF-1R specific inhibitor decreased MT1-MMP promoter activity, RNA and …
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IGF-1 signalling controls mitochondrial morphology and basal mitophagy in cancer
Insulin-Like Growth Factor 1 (IGF-1) signalling is known to support oncogenic transformation and the promotion of cancer development. A growing body of evidence has outlined the protective effect IGF-1 signalling has on the mitochondria, however this has been relatively underexplored in cancer. …
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Roles of Zinc in Skeletal Muscle Cells Growth
… food intake. Insulin-like growth factor (IGF) is the primary regulator of postnatal muscle growth and there is substantial evidence that the effects of zinc deficiency alter IGF mediated muscle growth. The overall goal of this thesis was to examine how zinc altered IGF effects on muscle …
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IGF2 Promotes Activation of Estrogen Receptors in Basal-like Breast Cancer Cells
The autocrine-paracrine effects of IGF2 are important in the growth and differentiation of normal breast. In breast cancer (BC), IGF2 is initially stimulated by estrogen, progesterone and prolactin to regulate proliferation and cancer progression. These actions are mediated by the IGF-1R and …
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Use of Kinase Inhibitors to Illuminate Signaling Pathways in Breast Cancer
… as the insulin-like growth factor 1 receptor (IGF-1R) and the protein kinase B (AKT) can also interfere and cause cell growth and replication. In this study, we propose that the use of a multi-agent treatment targeting the HER-2, IGF-1R, and AKT proteins will be more effective than a …
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Proliferative and survival pathways in oesophageal cancer
… of this study was to determine the role of EGFR, IGF-1R and CXCR2 in proliferation and survival of OSCC cells.
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Effect of aging on metabolic status and hormone responsiveness in the ovary
… significant effects of animal age on GLUT4 and IGF-1R expression as well. In general, increased expression of selected AMPK subunits occurred in older animals and, with one exception, in cells pre-treated with medium that did not contain FBS or additional glucose. Although the underlying cause …
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Metabolic Mechanisms of Nutritionally Regulated Hormone Signaling on T Helper Cell Function
… insulin, and insulin like growth factor 1 (IGF-1) are increased, whereas they are decreased in the setting of undernutrition. Either undernutrition or overnutrition results in a dysregulated immune response that contributes to increased susceptibility to infection. Immune cells, especially T …
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Development of a High-Throughput 3D Tumor Model for Bone Sarcomas
… the secretion of insulin-like growth factor-1 (IGF-1) which, in turn, resulted in shear stress-dependent cell sensitivity to the IGF-1 receptor (IGF-1R) blockade, a central player in ES progression. We then leveraged these findings to culture ES cells on 3D-printed scaffolds under flow perfusion …
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Y-box binding protein-1 (YB-1) is a bio-marker of aggressiveness in breast cancer and is a potential target for therapeutic intervention
… a small molecule inhibitor for activated IGF-1R/IR on SUM149 cells. We demonstrate that activated IGF-1R is associated with poor survival in primary breast tumours and, that BMS-536924 reduces uPA expression through inhibition YB-1 in SUM149 cells. We therefore conclude that YB-1 is a …
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Suppression of Carcinogenesis and Tumor Progression by an Energy Restriction-Mimetic Agent in Murine Models of Prostate Cancer
… including insulin like growth factor 1 (IGF-1) and its receptor IGF-1R, Myc, the androgen receptor (AR), and cyclins D1 and E. OSU-CG5’s activity was also investigated using transgenic adenocarcinoma of the mouse prostate (TRAMP) mice. Treatment of 6-week-old TRAMP mice with 100 mg/kg/day …
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Therapeutic Targeting of BMP and TGF-β Signalling Pathways for the Resolution of Pulmonary Arterial Hypertension
… has identified novel proteins including PPP1CA, IGF-1R, MPP1, MCM5 and SRC each capable of modulating the BMPRII signalling. Taken together, this study for the very first time has identified novel compounds with pro-BMP and anti-TGFβ activities which may provide therapeutic intervention prior to …
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Regulation of the Insulin-like Growth Factor 1-Secretory Clusterin Expression Axis in Genomic Instability and Cell Stress
… leading from ATM to sCLU expression mediated by IGF-1/IGF-1R/MAPK activation was uncovered. IGF-1 ligand promoter activity, mRNA, and protein expression induced after exposure to ionizing radiation (IR), hydrogen peroxide, or topoisomerase I and II-alpha poisons matched sCLU expression. Elevated …
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