Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 170 for “"IGF-1"”.
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The Role of IGF-1 and Notch Signaling in Thoracic Malignancies.
… the onset of MM. Insulin like growth factor-1 (IGF-1) signaling plays a central role in all thoracic malignancies and in the process of SV40-mediated malignant transformation of human cells. We have found that in SV40-transformed human mesothelial cells (HM) the Large T antigen (Tag), p53, pRb …
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Targeting bone-microenvironment-tumour cell interactions : IGF-1 receptor kinase inhibitors.
… intratibial injection techniques respectively. IGF-1 and its receptor are known to play important roles in both bone metabolism and breast cancer. Therefore a study of the effects of IGF-1 receptor inhibition on tumour cell – bone cell interactions was performed. In vitro studies showed that the …
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IGF-1 signalling controls mitochondrial morphology and basal mitophagy in cancer
Insulin-Like Growth Factor 1 (IGF-1) signalling is known to support oncogenic transformation and the promotion of cancer development. A growing body of evidence has outlined the protective effect IGF-1 signalling has on the mitochondria, however this has been relatively underexplored in cancer. …
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Characterization of Alsin and Its Role in IGF-1-Mediated Neuronal Survival
… to couple Rab5 activation specifically to the IGF-1 signal transduction pathway via its regulation of IGF-1 receptor endocytosis. This function of Alsin was shown to be essential for IGF-1-mediated cell survival. These results provide the first characterization of Alsin and identify a novel …
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Genexpression der GH- IGF-1 Kaskade in endokrin aktiven und endokrin inaktiven Hypophysenadenomen
… Da GH über den Insulin-like-growth-factor-1 (IGF-1) eine mitogene Wirkung auf potentiell vorhandenes, postoperatives Tumorrestgewebe entfalten könnte, stellten wir die Frage, ob neben GH und IGF-1 auch der Growth-Hormon-Receptor (GH-R) und der IGF-1-Receptor (IGF-1-R) exprimiert werden und …
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The Role of Igf-1 and Il-4 in Myeloid Progenitor Cell Survival
… these cells. In this thesis, we demonstrate that IGF-I and IL-4, a cytokine produced by activated T-lymphocytes, enhance the survival of CSF-stimulated progenitor cells. One particular enzyme activated by both IGF-I and IL-4 is phosphatidylinositol 3$\sp\prime$-kinase, a lipid kinase which …
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THE EFFECTS OF AGE, GH AND IGF-1 ON NEUROMUSCULAR RECOVERY FOLLOWING NERVE TRANSECTION
… hormone (GH) and insulin-like-growth factor 1 (IGF-1). The purpose of this research was to examine the effect of age, GH and IGF-1 on neuromuscular recovery after peripheral nerve injury in aged rats. It was found that with aging, there is a significant impairment in neuromuscular recovery after …
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Regulation of IGF-1 bioactivity by dietary hormones, impact of glucagon and insulin-induced hypoglycemia
… wurde untersucht. Veränderungen der GH-IGF-1 Achse in Verbindung mit ernährungsbedingten Erkrankungen wurden früher beschrieben. Das Wechselspiel zwischen GH, gesamt IGF-1 und verschiedenen hemmenden und stimulierenden IGF-1 bindenden Proteinen (IGFBPs) bestimmt die IGF-1 Bioaktivität, …
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Μελέτη της επίδρασης της αποσιώπησης της ισομορφής Eb του IGF-1 στη φυσιολογία του κυττάρου
Ο ινσουλινομιμητικός αυξητικός παράγοντας (IGF-1) αποτελεί σημαντικό βασικό ρυθμιστή κυτταρικών διεργασιών όπως ο πολλαπλασιασμός, η επιβίωση και η απόκριση σε στρες. Από την πρόδρομη μορφή του (proIGF-1) μπορούν να προκύψουν τρεις ισομορφές μέσω εναλλακτικού ματίσματος. Ο IGF-1Ea που είναι η πιο …
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Cartilage mechanobiology and transcriptional effects of combined mechanical compression and IGF-1 stimulation on bovine cartilage explants
… confirmed in several laboratories. Studies with IGF-1: Insulin-like growth factor-I (IGF-1) is a potent anabolic factor capable of endocrine and paracrine/autocrine signaling. Previous studies have demonstrated that mechanical compression can regulate the action of IGF-1 on chondrocyte …
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Investigating the effects of persistent organic pollutants (POPs) on insulin-like growth factor 1 (IGF-1) in grey seals
… of degradation. Insulin-like growth factor 1 (IGF-1) is a hormone produced by the liver which is important to numerous processes including metabolism, growth and development, disruption to any of these processes could severely impact survival and reproductive success.<br/><br/>Grey seals …
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Οξειδωτικό stress και κυτταρικός θάνατος οφειλόμενος σε ακτινοβόληση των CD34+ προγονικών αιμοποιητικών κυττάρων. Προστασία από την παρουσία του IGF-1
… παρουσία του ινσουλινικού αυξητικού παράγοντα IGF-1. Η προκαλούμενη από την ακτινοβολία ενδοκυττάρια παραγωγή ενεργών μορφών οξυγόνου μελετήθηκε παρουσία ή απουσία του IGF-1, 30 λεπτά και 24 ώρες μετά την ακτινοβόληση με χρήση κυτταρομετρίας ροής. Η έκφραση του αντιοξειδωτικού ενζύμου MnSOD …
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Die Effekte von Estradiol, Testosteron, Belamcanda chinensis und Cimicifuga racemosa auf die Expression von IGF-1 in Knochen und Leber von orchiektomierten Ratten
… und Cimicifuga racemosa auf die Expression von IGF-1 in Knochen und Leber von orchiektomierten RattenDas Androgendefizit im alternden Mann kann zur Osteoporose führen. Eine Testosteronsubstitution trägt aber zur Entwicklung eines Prostatakarzinoms bei. Deswegen sucht man nach alternativen …
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Genetic analysis of novel regulators of neuronal migration in Caenorhabditis elegans: the insulin/IGF-1 signaling pathway, a chromatin-binding factor ZFP-1 (AF10) and endogenous RNAi
… I explore novel roles for both the insulin/IGF-1 signaling pathway and RNAi factors in neuronal migration by using the embryonic anterior migrations of the hermaphrodite-specific neurons (HSNs) of C. elegans as a model. I demonstrate that the insulin/IGF-1 signaling pathway modulates the …
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Evaluation of a copper lysine complex and copper sulfate in weanling and finishing pigs, and the effect of copper supplementation on circulating growth hormone and IGF-1 levels
… feeding elevated CU on serum growth hormone and IGF-1 levels. Two trials (176 pigs) were conducted in which pigs were fed 0, 100, 150, or 200 mg/kg Cu from CUS0₄ or CuLys. Elevated Cu increased daily gain and feed intake linearly, with no difference between the sources. Dietary CU linearly …
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The safety and efficacy of novel dual function coronary stent in porcine model of myocardial infarction
… as a delivery platform of cardioprotective drug (IGF-1) downstream the coronary artery to the injured myocardium while maintaining the patency of the vessel via anti-proliferative drug (AZ1193). Methods: The stent coating was designed to deliver IGF-1 from the outer (external) layer while …
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Hormonal factors and insulin-like growth factor-1 in North American postmenopausal women
… remain unclear. Insulin-like growth factor-1 (IGF-1) levels have been positively associated with breast cancer and are a potential mechanism. Objectives: The objectives of this thesis are: 1) to explore whether the reproductive risk factors and the lifetime cumulative number of menstrual cycles …
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Regulation of the Insulin-like Growth Factor 1-Secretory Clusterin Expression Axis in Genomic Instability and Cell Stress
… leading from ATM to sCLU expression mediated by IGF-1/IGF-1R/MAPK activation was uncovered. IGF-1 ligand promoter activity, mRNA, and protein expression induced after exposure to ionizing radiation (IR), hydrogen peroxide, or topoisomerase I and II-alpha poisons matched sCLU expression. Elevated …
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Insulin-like growth factor 1 effects on mitochondrial dynamics and mitophagy in cancer
… conserved Insulin-Like Growth Factor 1 (IGF-1) signalling pathway is essential for growth and development and may facilitate cancer progression. While IGF-1 mediates mitochondria protection in some pathologies, whether it is essential for mitochondrial homeostasis in tumour cells remains …
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