Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"IFNs"”.
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Characterizing the role of thymic interferon in T cell development and selection
Type I and III interferons (IFNs) are robustly induced during infections, where they protect cells against viral infection and activate immune cells. Curiously, both type I and type III IFNs were reported to be produced at low levels in the thymus in the absence of infection – the site of T cell …
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Cell-Specific Inhibition of Interferon Production by Rotavirus
… The activated immune system produces interferon (IFNs), a cytokine that drives expression of antiviral effectors, known as IFN-stimulated genes (ISGs). The studies reported in this thesis investigate the differences in rotaviral infection of two human cell lines; the intestinal (Caco-2) and the …
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Regulation of type I interferons in murine dendritic cells
… adaptive immune responses. Type I interferons (IFNs), as important danger signals, activate cDCs through the canonical type I IFN receptor signaling. Type I IFNs are the first line of host defense against viral infection by up-regulating IFN-stimulated genes (ISGs). However, there are …
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Characterization of The Roles of Carma3 and Bcl10 In Virus-Triggered Rig-I/Mavs Signaling Pathway
… cytoplasm to initiate the production of type-I IFNs and proinflammatory cytokines by mitochondrial protein MAVS, which forms a prion-like structure to recruit TBK1and IKK complex to activate IRF3 and NF-κB, respectively. Herein, we revealed the important roles of CARMA3 and BCL10 in RIG-I/MAVS …
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Induction and Regulation of CXCL10 in Hepatocytes During Hepatitis C Virus Infection
… of hepatocyte-derived type I and type III IFNs and specific pro-inflammatory transcription factors to CXCL10 induction were also examined. In this study, PHH and immortalized PH5CH8 hepatocytes were confirmed to express functional TLR3 and RIG-I. Specific activation of TLR3 and RIG-I led to …
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Innate Immune Sensing and Signaling of Cytosolic DNA
… including the production of type-I interferons (IFNs). Endogenous DNA that is inappropriately cleared can also accumulate in cytosol and drive pathological inflammation and autoimmune diseases such as systemic lupus erythematosus (SLE). It is well known that cytosolic DNA induces IFNs through the …
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Equine innate and adaptive immunity to viral infections
… in monocyte-derived DCs. Enhanced expression of IFNs in immune cells by CpG-DNA is not only crucial for host viral clearance, but also important in mediating host immune responses due to IFNs' anti-inflammatory effects. Compared to the relatively weaker activation of equine innate immunity by …
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On the function of the interferon-inducible p53 target gene TRIM22
… progression and viral defence. Interferons (IFNs) are pleiotropic cytokines with antiviral, anti-proliferative, proapoptotic and immunmodulatory functions. Similar to TRIM22, many TRIM proteins are upregulated in response to IFNs, and many are involved in defence towards viruses, including …
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Role of Dendritic Cells in Pathology of Respiratory Syncytial Virus Infection in Neonates
… viral infection through type I interferons (IFNs). Despite data demonstrating importance of mDCs and pDCs in protection against RSV, it has not been studied in an age appropriate model. Using a neonatal mouse model, we have shown that downregulation of IL-4 receptor alpha (IL-4Rα) on …
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Sensing of Picornavirus Infections
… response through the expression of interferons (IFNs) and cytokines. For RNA viruses, which replicate in the cytoplasm, the cytoplasmic RIG-I like receptors are responsible for this sensing. The contributions of these receptors to sensing viruses of the Picornaviridae family were investigated. …
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The Role of Interleukin-10 Family Members in Inflammatory Skin Diseases. Understanding the mechanism of action of interferon lambda and interleukin-22 on human primary keratinocytes and dermal fibroblasts with a focus on healing responses in inflammatory skin diseases
… scars depending on the subtype. Interferons (IFNs), including the skin specific IFNλ mainly activate STAT1, which results in inflammation in CLE and may play a significant role in scar formation in chronic discoid CLE. IL-22 activates STAT3 and it is emerging as a mediator with significant …
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Engineering Intratumoral Cytokine Therapies for Cancer
… of IFN and IFN, mediated by anchoring these IFNs to co-injected aluminum-hydroxide (alum) particles, greatly improved their tolerability and efficacy. The improved efficacy of alum-anchored IFNs could be attributed to sustained pleiotropic effects on tumor cells, immune cells, and …
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Characterization of the anti-type I interferon effects of the cellular flice-like inhibitory protein (CFLIP)
… against viral infection. Interestingly, these IFNs also maintain roles apart from viral infection including participating in the pathophysiology of tumor biology and autoimmunity. Previous studies found that cFLIPL could inhibit IFNb production. My work demonstrated that this was by inhibiting …
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Cryptosporidium Uses Its Cspv1 Virus to Activate Host Type I IFN Response and Attenuate IFN-Gamma-Mediated Epithelial Anti-Parasitic Defense
… pathogen infections. There are three types of IFNs and all three types of IFN signaling have been observed in intestinal epithelium following Cryptosporidium infection. The activation of type II and III IFN signaling is mediated through toll-like receptors (TLRs). Both type II and type III IFNs …
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Gene Expression Changes in Immune Cells During Human Immunodeficiency Virus 1 (HIV-1) Infection
… in HIV-infected patients, whereas both type I IFNs and HIV Tat induced genes in patterns consistent with those seen in patients. In fact, the thirteen IFN-induced patterns were indistinguishable from each other. Tat treatments induced interferon-stimulated genes (ISGs) as well as other genes …
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THE ROLE OF TYPE I INTERFERONS IN THE HOST CD8+ T CELL RESPONSE DURING GAMMAHERPESVIRUS INFECTION
… was undertaken to evaluate the role of type I IFNs in MHV68-specific CD8+ T cell expansion, differentiation, and functionality utilizing a murine type I IFN receptor knockout strain (IFNAR1-/-).
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Applying a new technique, the interferon gamma liposomal delivery system to improve drug delivery in the treatment of Lung Cancer
… Published data show the use of interferons (IFNs) in the treatment of lung tumours due to their potential in displaying antiproliferative, anti-angiogenic, immunoregulatory, and proapoptotic effects. Type1 IFNs have been employed as treatments for many types of cancer, both for haematological …
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Applying a new technique, the interferon gamma liposomal delivery system to improve drug delivery in the treatment of Lung Cancer
… Published data show the use of interferons (IFNs) in the treatment of lung tumours due to their potential in displaying antiproliferative, anti-angiogenic, immunoregulatory, and proapoptotic effects. Type1 IFNs have been employed as treatments for many types of cancer, both for haematological …
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CHARACTERISATION OF A NOVEL SMALL MOLECULE INHIBITOR FOR IMMUNE ACTIVATION IN TRIPLE NEGATIVE BREAST CANCER
… gene and protein expression of Type I/III IFNs in TNBC cell lines. This signalling is dependent on the RIG/MAVS cytosolic RNA-sensing pathway, and is possibly triggered by increased cytosolic localisation of mitochondrial dsRNA. Using a 3D vascularised TNBC model, CHL-4 treatment increased …
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Identification and Characterization of Auxiliary Factors in Innate Antiviral Immunity
… or dsRNA-induced expression of type I and III IFNs and ISGs in mouse embryonic fibroblasts (MEFs), mouse hepatoma hepa1-6 cells, and primary mouse lung fibroblasts. Mechanistically, SRMS acted downstream of the RLRs and their adaptor MAVS. SRMS loss led to diminished phosphorylations of TBK1 …
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