Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"IFNg"”.
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Using Mice with Conditional Deletion of the IFNg Receptor to Identify the Cellular Targets of IFNg during Development of Anti-Listeria Immune Responses
<p>Host responsiveness to IFNg is critical for resolution of Listeria infection, but the identities and roles of IFNg responsive cells that initiate this process remain unclear. In this thesis, unique mice displaying conditional loss of the IFNg receptor: Ifngr1f/f mice) in different tissues have …
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The intrinsic role of SOCS1 in intestinal epithelial cells
… crypt-derived colonoid populations from the WT, Ifng-/- and Socs1-/- x Ifng-/- (DKO) mouse models were produced. Morphological analysis, gene and/or protein expression profiling of markers of IEC populationages (Lg5, E-cadherin, Muc2 and Tff3), autophagy (P62), ER stress response (spliced Xbp1) …
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The neonatal anti-viral response fails to control measles virus spread in neurons despite interferon-gamma expression and a Th1-like cytokine profile
… the brain.</p> <p>The role of interferon-gamma (IFNg), a key anti-viral cytokine in controlling adult CNS infections, was explored during a neuronally-restricted MV infection in the neonatal brain. We hypothesized that neonatal mice would be deficient in either IFNg production or in the …
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Immunotoxicity of Dermal Permethrin and Cis-Urocanic Acid: Effects of Chemical Mixtures in Environmental Health
… using mice with deleted genes. Vehicle-exposed IFNg knockout mice displayed approximately a 22.1% depression in the ear swelling response as compared to control C57BL/6N mice, suggesting that this cytokine may be required for mounting a control-level hypersensitivity response. Ear swelling in …
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Attenuated Responses To Inflammatory Cytokines In Mouse Embryonic Stem Cells: Biological Implications And The Molecular Basis
… of mESCs to the cytotoxic effects from IFNg, which is an inflammatory cytokine highly presented during early embryogenesis, and other inflammatory conditions were demonstrated, including attenuated expressions of inflammatory and signaling molecules, inactivated transcription factor and …
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Einfluss atopischer Prädisposition auf allergenspezifische Proliferation und Zytokinprofile maternaler und fetaler mononukleärer Blutzellen
… ELISA bestimmt wurden: IL4, IL5, IL10, IL13, IFNg. ERGEBNISSE: Angegeben werden jeweils die positiven Proliferationsantworten in Prozent (SI > 2) und der Stimulationsindex (SI): IL2: M 100 (21), N 100 (26); BLG: M 98 (14), N 92 (17); OVA: M 36 (2), N 31 (2); Derp: M 32 (2), N 17 (2). M+, M-, …
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A Novel Mechanism of Skin Tumor Promotion Involving Interferon-Gamma (Ifnγ)/Signal Transducer and Activator of Transcription-1 (Stat1) Signaling In Epidermis
… CHRY but not TPA upregulated interferon-gamma (IFNg) mRNA in the epidermis and that the induction of both IRF-1 and uStat1 was dependent on IFNg signaling. Stat1 deficient (Stat1<sup>-/-</sup>) mice were highly resistant to skin tumor promotion by CHRY. In contrast, the tumor response (in terms …
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Der Einfluß von Virusinfektion und Impfung auf autoreaktive T-Lymphozyten bei der Multiplen Sklerose
… wurden, ergab sich weder mit dem sensitiven IFNg-ELISPOT noch mit der quantitativen RT-PCR ein Anhalt für erhöhte Autoimmunreaktivität gegen die zwei untersuchten Myelin-Antigene MBP und MOG. Im Gegensatz dazu konnten mit dem IFNg-ELISPOT-Assay bei einigen gesunden Spendern und MS-Patienten …
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Bhlhe40: Required For Tumor Microenvironment Remodeling and Immune Checkpoint Therapy Efficacy
… dysregulated metabolism, NF-kB signaling, and IFNg response within certain subpopulations of CD4<sup>+</sup> and CD8<sup>+</sup> T cells. Intratumoral CD4<sup>+</sup> and CD8<sup>+</sup> T cells from BHLHE40-deficient mice also exhibited higher expression of the inhibitory receptor gene …
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A Study of the Molecular Immunogenetics of Type 1 Diabetes in Man
… The association of the 3 I 3 genotype of the IFNG CA repeats and no association of IL-4 C (-590) T polymorphism may support the idea of dominance of the TH1 cytokine profile and type 1 diabetes suggesting a cell mediated disease. The IL-6 G (-174) C result attests an existing hypothesis of the …
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Basi molecolari della differente risposta delle cellule alpha e beta del pancreas di mammifero all apoptosi mediata da citochine: implicazioni patogenetiche nel Diabete Mellito
… tra le citochine pro-infiammatorie l IL-1b, l IFNg ed il TNFa rappresentano i principali effettori degli eventi descritti. E interessante notare come l'azione deleteria delle citochine sia specificatamente rivolta alle cellule beta pancreatiche, mentre le cellule alpha risultano più resistenti …
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The characterisation of dendritic cell, microglial, macrophage and T cell responses during mycobacterial infection of the central nervous system
… CD86 molecule, pro-inflammatory cytokines (IFNg, TNFa, IL-1b, IL-6, IL-12) and an anti-inflammatory cytokine (IL-10) in comparison to saline control mice. We also demonstrated preferential recruitment of mature conventional DCs (CD11c+, MHCII+) that express chemokine receptor-7 (CCR7) to the …
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Die humane Komplementfaktor H-Genfamilie
… ist in den allen getesteten Gliomazellinien mit IFNg stimulierbar. Faktor H verhält sich also im Gehirn, ebenso wie in der Leber, als Akute-Phase-Protein und verhindert eine ungewünschte Komplementaktivierung im Zuge von Infektionen, Verletzungen und Erkrankungen des Gehirns. Durch die …
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The Role of Interferon Gamma in the Stroma of Growing and Regressing Tumours
… der Rolle von Interferon gamma (IFNg) in der Abstoßung von Tumoren durch geringe Konzentrationen von Cyclophosphamide (Cy). Diese Arbeit zeigt, daß haematopoetische Zellen IFN-g produzieren, welches für die Abstoßung von Tumoren notwendig ist. Mit Hilfe des Cincinnati Zytokin …
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Immunomodulatory effect of the Acanthocheilonema viteae product ES-62 in arthropod extract models of asthma
… allergy-amplified Interleukin-4 (Il4), Il13 and Ifng pulmonary gene expression was reduced with ES-62 treatment.;ES-62 also decreased the level of peribronchial inflammatory infiltrate and marginally reduced the Immunoglobulin G1 (IgG1) response to CRE. Essentially no activity was seen at 2 …
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HIGH-THROUGHPUT PROFILING OF INNATE IMMUNE CELLS TO UNVEIL TUMOR ESCAPE MECHANISMS IN MATCHED COLORECTAL CANCER AND LIVER METASTASES
… compared to circulation, and diversified into IFNG-activated, cytotoxic-enriched, and stress-adapted states, with no developmental connection to hepatic CD56dim NK cells. Importantly, CRLM-associated CD56bright NK cells displayed concurrent upregulation of effector programs and multiple …
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ROLE OF IL-10 PRODUCING EOMES+ TR1-LIKE CELLS IN MELANOMA
… (ICB) treated patients showed an increased IFNg production, as well as for CD4+ T helper cells and CD8+ T cells, while Tregs have a significant reduction in IL-10 production, suggesting an enhancement of cytotoxic differentiation following treatment. When stimulated with melanoma-associated …
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Immunbiologie hepatischer Natürlicher - Killer T- (NKT-) Zellen
… Komplex, gemessen an der Expression von CD69 und IFNg in beiden Zelltypen. Des Weitern rekrutierten stimulierte und aktivierte NKT- und T - Zellen in die Leber, und die Proliferation der NKT - Zellen erwies sich dynamisch am Bedarf reguliert. NKT - Zellen von Va2Vb5 T - Zellrezeptor transgenen …
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Gestörte Expression von CD86 und ein verändertes intrazytoplasmatisches Zytokinmuster in Lymphozyten von Patienten mit Variablem Immundefektsyndrom (CVID)
… eine gesteigerte Expression der TH1-Zytokine IFNg und TNFa nach. Die phänotypischen T-Zellveränderungen wie auch die Verschiebung zu einer TH1-Immunantwort sind als reaktive und wohl unspezifische Veränderung in einer Situation rezidivierender inflammatorischer Reize im Rahmen der durch die …
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